ID M0EHK6_9EURY Unreviewed; 814 AA.
AC M0EHK6;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Hef nuclease {ECO:0000313|EMBL:ELZ47266.1};
GN ORFNames=C463_03078 {ECO:0000313|EMBL:ELZ47266.1};
OS Halorubrum californiense DSM 19288.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Halorubraceae; Halorubrum.
OX NCBI_TaxID=1227465 {ECO:0000313|EMBL:ELZ47266.1, ECO:0000313|Proteomes:UP000011586};
RN [1] {ECO:0000313|EMBL:ELZ47266.1, ECO:0000313|Proteomes:UP000011586}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19288 {ECO:0000313|EMBL:ELZ47266.1,
RC ECO:0000313|Proteomes:UP000011586};
RX PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT strategies for static and dynamic osmo-response.";
RL PLoS Genet. 10:E1004784-E1004784(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ELZ47266.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AOJK01000015; ELZ47266.1; -; Genomic_DNA.
DR RefSeq; WP_008440957.1; NZ_AOJK01000015.1.
DR AlphaFoldDB; M0EHK6; -.
DR STRING; 1227465.C463_03078; -.
DR PATRIC; fig|1227465.4.peg.605; -.
DR OrthoDB; 9764at2157; -.
DR Proteomes; UP000011586; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd12089; Hef_ID; 1.
DR CDD; cd20075; XPF_nuclease_XPF_arch; 1.
DR Gene3D; 3.40.50.10130; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 1.20.1320.20; hef helicase domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR041663; DisA/LigA_HHH.
DR InterPro; IPR006166; ERCC4_domain.
DR InterPro; IPR041755; Hef_ID.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR010994; RuvA_2-like.
DR PANTHER; PTHR14025; FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER; 1.
DR PANTHER; PTHR14025:SF20; FANCONI ANEMIA GROUP M PROTEIN; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF02732; ERCC4; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF12826; HHH_2; 1.
DR Pfam; PF21210; RNA_helicase_helical; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00891; ERCC4; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00278; HhH1; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 27..194
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 355..514
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 516..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..559
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 814 AA; 89203 MW; 25544A76375329B4 CRC64;
MATEAAGIDR DLLVDDFLQR RRYQLELADA AADEHTLVCL PTGLGKTTVS LLVTAERLHE
AGGKALFLAP TKPLVQQHAD FYREALSIPD DDIVVFTGDV KPDDRVALWD DARIVIATPQ
VVENDLVGNR ISLRDVTHLT FDECHRATGD YAYVYIAERY HADAADPLVT GMSASPGGDT
EEIETVCENL GLVNVEVMTE EDADVDEYTH DTDVRWEQVT LPDEVLDIRD ALNEVITDRL
EKLKQLGVTD TTNPDLSQKD LNKMRGQLKQ MMDNDQSDGY KGMSTHAEVM KLRRATELVE
TQSVESVRRY FERQREAARS SGASKASQRM VADPKVREAM RKAESFDGLH PKFSKARILL
AETLGIDGGE RAILFTESRD TAEALVEFLS ASFDVRKFVG QGDKDGSDGM SQKQQQETLD
EFKAGEFEVL VSTSVAEEGL DVPEVDLVCF YEPVPTAIRS IQRKGRTGRQ AEGKVVVLMA
EDTRDEAFFW ISRRREKKMA SQLTELKEAT DDIEETVGDD GQAGLDAFAS GSGSEDESGD
EAASSEGDGD ADEPGDAGLT DFAEEARAGG DEETGADEAD DADTGADDDG VVATAGVDEG
IEVVVDQREL DSSIAKDLST RDELVTRLET LAVGDYVLSD RVAVERKSAA DFVDSMLDSD
RSMFEQVGEL SRAYARPVMV VEGTNLYGQR DIDPNAIRGA LASLAVDFDV SVLRTEGEED
TTELLATIAK REQETRDREV SVHGEKTTKT RAEQQEYVVS SIADIGPVTA RTLLEYFGTV
EAVMTAPEDD LLEVDGVGPV TAERIREVVG SEYE
//
