ID   M0F1R7_9EURY            Unreviewed;       596 AA.
AC   M0F1R7;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   SubName: Full=PUA domain containing protein {ECO:0000313|EMBL:ELZ52569.1};
GN   ORFNames=C467_14174 {ECO:0000313|EMBL:ELZ52569.1};
OS   Halorubrum hochstenium ATCC 700873.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC   Halorubraceae; Halorubrum.
OX   NCBI_TaxID=1227481 {ECO:0000313|EMBL:ELZ52569.1, ECO:0000313|Proteomes:UP000011689};
RN   [1] {ECO:0000313|EMBL:ELZ52569.1, ECO:0000313|Proteomes:UP000011689}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700873 {ECO:0000313|EMBL:ELZ52569.1,
RC   ECO:0000313|Proteomes:UP000011689};
RX   PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA   Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA   Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT   "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT   strategies for static and dynamic osmo-response.";
RL   PLoS Genet. 10:E1004784-E1004784(2014).
CC   -!- PATHWAY: tRNA modification; archaeosine-tRNA biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00005030}.
CC   -!- SIMILARITY: Belongs to the archaeosine synthase type 1 family.
CC       {ECO:0000256|ARBA:ARBA00008906}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ELZ52569.1}.
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DR   EMBL; AOJO01000064; ELZ52569.1; -; Genomic_DNA.
DR   RefSeq; WP_008586539.1; NZ_AOJO01000064.1.
DR   AlphaFoldDB; M0F1R7; -.
DR   STRING; 1227481.C467_14174; -.
DR   GeneID; 72714917; -.
DR   PATRIC; fig|1227481.4.peg.2793; -.
DR   OrthoDB; 115061at2157; -.
DR   UniPathway; UPA00393; -.
DR   Proteomes; UP000011689; Unassembled WGS sequence.
DR   GO; GO:0016763; F:pentosyltransferase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0006400; P:tRNA modification; IEA:InterPro.
DR   CDD; cd21149; PUA_archaeosine_TGT; 1.
DR   Gene3D; 3.10.450.90; ArcTGT, C2 domain; 1.
DR   Gene3D; 2.30.130.10; PUA domain; 1.
DR   Gene3D; 3.20.20.105; Queuine tRNA-ribosyltransferase-like; 1.
DR   Gene3D; 3.40.50.10630; Uracil-DNA glycosylase-like; 1.
DR   InterPro; IPR040777; DUF5591.
DR   InterPro; IPR002478; PUA.
DR   InterPro; IPR015947; PUA-like_sf.
DR   InterPro; IPR036974; PUA_sf.
DR   InterPro; IPR036511; TGT-like_sf.
DR   InterPro; IPR029402; TGT_C2.
DR   InterPro; IPR038250; TGT_C2_sf.
DR   InterPro; IPR002616; tRNA_ribo_trans-like.
DR   InterPro; IPR004521; Uncharacterised_CHP00451.
DR   InterPro; IPR036895; Uracil-DNA_glycosylase-like_sf.
DR   NCBIfam; NF040592; tRNA_mod_ArcS; 1.
DR   NCBIfam; TIGR00451; unchar_dom_2; 1.
DR   PANTHER; PTHR46499:SF2; ARCHAEOSINE SYNTHASE; 1.
DR   PANTHER; PTHR46499; QUEUINE TRNA-RIBOSYLTRANSFERASE; 1.
DR   Pfam; PF17884; DUF5591; 1.
DR   Pfam; PF01472; PUA; 1.
DR   Pfam; PF01702; TGT; 1.
DR   Pfam; PF14810; TGT_C2; 1.
DR   SMART; SM00359; PUA; 1.
DR   SUPFAM; SSF88802; Pre-PUA domain; 1.
DR   SUPFAM; SSF88697; PUA domain-like; 1.
DR   SUPFAM; SSF51713; tRNA-guanine transglycosylase; 1.
DR   SUPFAM; SSF52141; Uracil-DNA glycosylase-like; 1.
DR   PROSITE; PS50890; PUA; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011689};
KW   tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT   DOMAIN          528..595
FT                   /note="PUA"
FT                   /evidence="ECO:0000259|SMART:SM00359"
FT   COILED          204..231
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   596 AA;  65363 MW;  934385D6446E0CB7 CRC64;
     MTDHFEVHER DGAARLGEVR LADPVTTPAL ADPFLDDAGS LWAGDREVPD GDENALTVLP
     HRSFPAGTRD EVRESFAVDH PDAAFPTAAV VDSEGARDLG ADAYLLSDAQ GFVGHGEAFR
     DAILRAKGSL PPDAALGLSG VVTPRNVAVL AYAGVDLVDA TLARTKGTQG MYLTADAEHF
     LEDLDELPCA CPACANPRSE FTRADCAEHN VNALRAELRR VRERIRSGRL RDYVEGQARH
     EGWLTAALRE FDDQWGYLEA RTPLMRDAEV TAASAETLDR VEIRRFADRV TSRYRNRFTD
     QPLVLVPCSA TKPYSDSQSH RQFHDAIKWR GHTVSMTSPI GVVPQELETT YPAQHYDSVV
     TGDWSEDEIS FVAEVLRRYL ERNDYSRVVA HVPEDGYREI CERVEAAPEI DVPFEYTCVD
     HPTTDESLGE LNAALQGEPA YSKREREHNT VRALADYLLG DGAGDDLFGG EIRTTGRYPK
     LQVWGDDPDA GREGEPGEQL ATMVPQYGTL SFTLAGARRW VESDAPTKRV EIDAFVPHGS
     VLAPGVVDAD DGIRVGDEVV IEGPKAFAVG RAEMSGPEMA GSTRGVAVQV RHVDER
//