ID   M0HW27_9EURY            Unreviewed;       508 AA.
AC   M0HW27;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Sialidase {ECO:0000313|EMBL:ELZ87928.1};
GN   ORFNames=C452_14165 {ECO:0000313|EMBL:ELZ87928.1};
OS   Haloferax alexandrinus JCM 10717.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC   Haloferacaceae; Haloferax.
OX   NCBI_TaxID=1227458 {ECO:0000313|EMBL:ELZ87928.1, ECO:0000313|Proteomes:UP000011577};
RN   [1] {ECO:0000313|EMBL:ELZ87928.1, ECO:0000313|Proteomes:UP000011577}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 10717 {ECO:0000313|EMBL:ELZ87928.1,
RC   ECO:0000313|Proteomes:UP000011577};
RX   PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA   Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA   Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT   "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT   strategies for static and dynamic osmo-response.";
RL   PLoS Genet. 10:E1004784-E1004784(2014).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ELZ87928.1}.
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DR   EMBL; AOLL01000028; ELZ87928.1; -; Genomic_DNA.
DR   AlphaFoldDB; M0HW27; -.
DR   PATRIC; fig|1227458.3.peg.2783; -.
DR   Proteomes; UP000011577; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR018905; A-galactase_NEW3.
DR   InterPro; IPR013783; Ig-like_fold.
DR   PANTHER; PTHR35902:SF3; ALPHA-GALACTOSIDASE NEW3 DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR35902; S-LAYER DOMAIN-LIKE PROTEIN-RELATED; 1.
DR   Pfam; PF10633; NPCBM_assoc; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        479..501
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          378..453
FT                   /note="Alpha-galactosidase NEW3"
FT                   /evidence="ECO:0000259|Pfam:PF10633"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..23
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   508 AA;  54549 MW;  F358CA0BBE03A0D5 CRC64;
     MYGSPDIDVF TSTSEFEPGT QSQLRLTLRN NGEIDQSGPE RYESRVTTAR GVTVEARPGD
     APVEINTGTI GAGNVPTGTV DLSPIDITVS ENATPGTYRI PVEVSYTYTR LVDYDPSGAE
     YTDNTRTRTH YVTVRVRDQP RFEVVETETT AQVGNTGDLS VTVENTGTRA ATDASVTATS
     RSDELVFGTA SESSTAQVGR WAVGERRTVN YTVSLAEDAT VRGYTVNLDV DYTDTDGIAR
     TSRTLNVGVT PVEEQSFSLE NVTTNLRVGA DGTVSGTVVN DGPKRVDDPV LRFSSSNPNI
     NVESSEYALP DLEPGDSADF SYEVGVSDAA NANVQQLNLS VAYRNSRGNT RISDSLTTNA
     EIAPHRDRFV VEVVNNTIEA GSERALRVRV TNNGDEPLTN IEAKAFVSDP LSSGNDEGII
     SELPPGESEE FTIALSAGAN ALPKRYPVSF DFQYEMPDGD TEVSQTYTTP IEVIESEGGG
     LPVGLIVGAV IVIGVLGVFG WRRFNTDE
//