ID   M0NDW4_9EURY            Unreviewed;      1092 AA.
AC   M0NDW4;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   SubName: Full=DNA methylase N-4/N-6 domain-containing protein {ECO:0000313|EMBL:EMA54880.1};
GN   ORFNames=C451_05915 {ECO:0000313|EMBL:EMA54880.1};
OS   Halococcus thailandensis JCM 13552.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halococcaceae; Halococcus.
OX   NCBI_TaxID=1227457 {ECO:0000313|EMBL:EMA54880.1, ECO:0000313|Proteomes:UP000011680};
RN   [1] {ECO:0000313|EMBL:EMA54880.1, ECO:0000313|Proteomes:UP000011680}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 13552 {ECO:0000313|EMBL:EMA54880.1,
RC   ECO:0000313|Proteomes:UP000011680};
RX   PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA   Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA   Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT   "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT   strategies for static and dynamic osmo-response.";
RL   PLoS Genet. 10:E1004784-E1004784(2014).
CC   -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00006594}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EMA54880.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AOMF01000123; EMA54880.1; -; Genomic_DNA.
DR   AlphaFoldDB; M0NDW4; -.
DR   STRING; 1227457.C451_05915; -.
DR   PATRIC; fig|1227457.3.peg.1045; -.
DR   eggNOG; arCOG00108; Archaea.
DR   OrthoDB; 38200at2157; -.
DR   Proteomes; UP000011680; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR   GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR   GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR002941; DNA_methylase_N4/N6.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR010995; DNA_repair_Rad51/TF_NusA_a-hlx.
DR   InterPro; IPR001091; RM_Methyltransferase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF01555; N6_N4_Mtase; 1.
DR   PRINTS; PR00508; S21N4MTFRASE.
DR   SUPFAM; SSF47794; Rad51 N-terminal domain-like; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:EMA54880.1}; Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          570..877
FT                   /note="DNA methylase N-4/N-6"
FT                   /evidence="ECO:0000259|Pfam:PF01555"
FT   COILED          121..152
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1092 AA;  128282 MW;  B9D1F4E4E799E91D CRC64;
     MPEQSLDSLL ELDDIQESTL NNLRDAEFDS LDGLASATRN DLRGIDDINT STAVNILRYL
     EREGYRERRE VTEKQHQLQQ LLRDLFQFDT SDLDFGIYRI LNQRRDIIDD FIEEDLIRTV
     HDALEAVAAE ERAELEEEVK QARADVVEQL NEDVFTQEGE IKEEFRDFGM AEDYVEAKER
     LEQYEVAEET EARVFNDLYT FFSRFYERGD FHAKRRFSSQ DAKFMVPYNG EEVFFHWANR
     DQYYVKTSEQ FTTYRFQADG LDAEFRVEDA NVPQDNVKGD ERYFILGNDP VAWDEDEAIL
     TVTFQYRLIT EDEADEFVNI YNEVTGEDRS SFNYKTNTIL CTALHKQILD QLNARGPRET
     LQREDDGKTV LMQHLTRYTS KNTMDYFVHK DLGGFLQDEL DYYIQNDILN TAELVEADAD
     RDPHSLRRAR VVRKIADRVI TFLDQIESFQ KRLFEKRKFV TQTDYMVTLD KVPDRLYDEI
     INNEKQLEQW HEVYNTDEWR TDLSWQGEFT GDVLTSNPYL MIDTALFDGD FKWELLDSFD
     NIEDETDGVL LHGENFQAVN LIREKFSNAV DCVYIDPPYN TGNDGFLYKD KYRHSSWLSM
     MEDRLRLTRD LMSDDALMFS HIDDNEESNL RKLKQNIFGK DNFLASICWN NSYSPQMDAS
     GFSTTHDYIL TFGRKQGAKP YQIPFEQDVS QFRYKDEETG RRYRRRSLRK EGSNSLRSDA
     PNSWFSLEAP DGTEVWPYKP DGTEGCWRWS KETYLERKER LIEWVDTDEY GWQPYVKQFR
     DLDASKPPET VWSHEEVGHN HEAAEEIGAL LGRRAFKTAK PIRLLKRILQ ISTVGKARNI
     VLDYFAGSGT TGHAVINLNR EDNGDRKYIL VEMGEQFDTI LRPRVQKATF SSDWSESVPQ
     DNNGQSHMVK YHRIESYEDA LNNVVLEEPE NEHQQRLVEE QQDEYVSGYM LDFEAESPSL
     LEPVSFEHPF DYELEIEQSG NIRKSTTVDL VETFHYLLGA DVSGFEAREH QDRQYVVTRC
     GVEMENSIDS VLTVWRDAEK LDLEQEREWF EEQFEFNEFD RIYINTESFV PGAEPAEVTF
     KERMEAGHDG AE
//