ID   M0ZQR4_SOLTU            Unreviewed;       489 AA.
AC   M0ZQR4;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   SubName: Full=Tetrahydrofolylpolyglutamate synthase {ECO:0000313|EnsemblPlants:PGSC0003DMT400006046};
GN   Name=102603442 {ECO:0000313|EnsemblPlants:PGSC0003DMT400006046};
OS   Solanum tuberosum (Potato).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX   NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400006046, ECO:0000313|Proteomes:UP000011115};
RN   [1] {ECO:0000313|Proteomes:UP000011115}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX   PubMed=21743474; DOI=10.1038/nature10158;
RG   The Potato Genome Sequencing Consortium;
RT   "Genome sequence and analysis of the tuber crop potato.";
RL   Nature 475:189-195(2011).
RN   [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400006046}
RP   IDENTIFICATION.
RC   STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400006046};
RG   EnsemblPlants;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the folylpolyglutamate synthase family.
CC       {ECO:0000256|ARBA:ARBA00008276}.
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DR   AlphaFoldDB; M0ZQR4; -.
DR   EnsemblPlants; PGSC0003DMT400006046; PGSC0003DMT400006046; PGSC0003DMG400002352.
DR   Gramene; PGSC0003DMT400006046; PGSC0003DMT400006046; PGSC0003DMG400002352.
DR   Proteomes; UP000011115; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004326; F:tetrahydrofolylpolyglutamate synthase activity; IEA:InterPro.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.1190.10; Mur-like, catalytic domain; 1.
DR   InterPro; IPR001645; Folylpolyglutamate_synth.
DR   InterPro; IPR018109; Folylpolyglutamate_synth_CS.
DR   InterPro; IPR036565; Mur-like_cat_sf.
DR   InterPro; IPR036615; Mur_ligase_C_dom_sf.
DR   InterPro; IPR013221; Mur_ligase_cen.
DR   NCBIfam; TIGR01499; folC; 1.
DR   PANTHER; PTHR11136:SF0; DIHYDROFOLATE SYNTHETASE-RELATED; 1.
DR   PANTHER; PTHR11136; FOLYLPOLYGLUTAMATE SYNTHASE-RELATED; 1.
DR   Pfam; PF08245; Mur_ligase_M; 1.
DR   SUPFAM; SSF53623; MurD-like peptide ligases, catalytic domain; 1.
DR   SUPFAM; SSF53244; MurD-like peptide ligases, peptide-binding domain; 1.
DR   PROSITE; PS01011; FOLYLPOLYGLU_SYNT_1; 1.
DR   PROSITE; PS01012; FOLYLPOLYGLU_SYNT_2; 1.
PE   3: Inferred from homology;
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011115}.
FT   DOMAIN          96..334
FT                   /note="Mur ligase central"
FT                   /evidence="ECO:0000259|Pfam:PF08245"
SQ   SEQUENCE   489 AA;  52438 MW;  15976E646F3BD375 CRC64;
     MNNLSILCRL TRSIQRNMLC SVAGLVHNTR HAFSTLREDP ELDEMMEFLD SLKNFEKSGV
     PKGAGTDSED GFDLGRMRRL MGLMGNPQSR FKTVHIAGTK GKGSTAAFLS SILRAEGYSV
     GCYTRERITL GKWGEPVSAK ALNHHFNTRR EVIERAVKLE NGCLSHFEVF TAIAFSLFAE
     ENTEIAVVEA GLGGARDATN VISGPDLAIS IITTVGEEHL DALGGSLESI AVAKSGIVKN
     GRPLVIGGPL VPSIEYILRR KASSMSSPVV SASDPGNRSA LKGFCEVTGI PRQLCDIVLQ
     IEKDYDPSIE LLGVKLRMLG AHQLQNAVTA TCAALCLNKQ AHTKESARAL ENTLQMTFPK
     AKMVLVVAMA NDKDHLVGDL DAVFSTEVDI AGAKSRMASA SLLKCAWVNA SREMNMKVLD
     LKVAESEDQS LQAAGIVKSQ SILLAEGSLL ACIRAGVKIL NERAGEQPGI LVVTGSLHIV
     SAVLGYLHS
//