ID M1C1E8_SOLTU Unreviewed; 881 AA.
AC M1C1E8;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=protein-serine/threonine phosphatase {ECO:0000256|ARBA:ARBA00013081};
DE EC=3.1.3.16 {ECO:0000256|ARBA:ARBA00013081};
OS Solanum tuberosum (Potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400057635, ECO:0000313|Proteomes:UP000011115};
RN [1] {ECO:0000313|Proteomes:UP000011115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX PubMed=21743474; DOI=10.1038/nature10158;
RG The Potato Genome Sequencing Consortium;
RT "Genome sequence and analysis of the tuber crop potato.";
RL Nature 475:189-195(2011).
RN [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400057635}
RP IDENTIFICATION.
RC STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400057635};
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] +
CC phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:83421; EC=3.1.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00001512};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:61977; EC=3.1.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00001482};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; M1C1E8; -.
DR STRING; 4113.M1C1E8; -.
DR PaxDb; 4113-PGSC0003DMT400057635; -.
DR EnsemblPlants; PGSC0003DMT400057635; PGSC0003DMT400057635; PGSC0003DMG400022380.
DR Gramene; PGSC0003DMT400057635; PGSC0003DMT400057635; PGSC0003DMG400022380.
DR eggNOG; KOG0323; Eukaryota.
DR InParanoid; M1C1E8; -.
DR OMA; GWFPAEE; -.
DR Proteomes; UP000011115; Unassembled WGS sequence.
DR ExpressionAtlas; M1C1E8; baseline.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008420; F:RNA polymerase II CTD heptapeptide repeat phosphatase activity; IBA:GO_Central.
DR Gene3D; 3.30.160.20; -; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR039189; Fcp1.
DR InterPro; IPR004274; FCP1_dom.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR PANTHER; PTHR23081:SF0; RNA POLYMERASE II C-TERMINAL DOMAIN PHOSPHATASE-LIKE 1; 1.
DR PANTHER; PTHR23081; RNA POLYMERASE II CTD PHOSPHATASE; 1.
DR Pfam; PF00035; dsrm; 1.
DR Pfam; PF03031; NIF; 1.
DR SMART; SM00577; CPDc; 1.
DR SMART; SM00358; DSRM; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR PROSITE; PS50137; DS_RBD; 1.
DR PROSITE; PS50969; FCP1; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000011115};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}.
FT DOMAIN 133..381
FT /note="FCP1 homology"
FT /evidence="ECO:0000259|PROSITE:PS50969"
FT DOMAIN 701..767
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT REGION 515..582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 659..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 535..556
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 558..572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 881 AA; 98915 MW; 7AB17B1D19E31421 CRC64;
MFKSTVVLYE GERLVGEVEI YCEKGVLWGE KVIRISHYSP SSERCPPLAV LHTVTTGLSF
KLEPTKSKPL TQDSPLTLLH STCLRDNKTA VMSLGREELH LVAMQSKNIG GQCPCFWGFK
VASGLYDSCL TMLNLRCLGI VFDLDETLIV ANTMRSFEDR IEALQRKINS ESDPQRASVM
LAEVKRYQED KIILKQYAEN DQVVDNGKVI KSQSEVFPAL SDNHQPIVRP LIRLQDRNII
LTRINPMIRD TSVLVRLRPA WEDLRSYLTA RGRKRFEVYV CTMAERDYAL EMWRLLDPDS
NLINSQELLD RIVCVKSGLR KSLFNVFQDG NCHPKMALVI DDRLKVWDDK DQPRVHVVPA
FAPYFAPQAE GNNSVPVLCV ARNVACNVRG GFFKDFDEGL LQRISEVAYE DDIKQVPSAP
DVSNYLISED DPSAVNGNKD SLGFDGMADS EVERRLKEAM LASTSVPSQM TNLDPRLVPA
LQYPVPPVIS QPSIQSPVVP FPTQHLPQVT SVLKSSVTQI SPQDTSLQSS PAREEGEVPE
SELDPDTRRR LLILQHGQDT RDQVSSEPKF PMGTPLQVSV PPRVQPHGWF PAEEEMSPRQ
LNRPLPPKEF PLNPESMHIN KHRPPHPPFL PKMETSMPSD RVLFENQRLP KEVIPRDDRM
RFSQSQPSFR PPGEEVPLGR SSSSNRVLDL EPGHYDPYLE TPAGALQDIA FKCGAKVEFR
SSFLSSPELQ FSLEVLFAGE KVGEGTGRTR REAQRRAAEE SLMYLADKYL SCIKPDSSST
QGDGFRFPNA SDNGFVDNMS PFGYQDRVSH SFASEPPRVL DPRLEVFKKS VGSVGALREL
CAIEGLGLAF QTQPQLSANP GQKSEIYAQV AHLLPFLLCY C
//
