ID M1CGS3_SOLTU Unreviewed; 486 AA.
AC M1CGS3;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=NBS-coding resistance gene protein {ECO:0000313|EnsemblPlants:PGSC0003DMT400067146};
OS Solanum tuberosum (Potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400067146, ECO:0000313|Proteomes:UP000011115};
RN [1] {ECO:0000313|Proteomes:UP000011115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX PubMed=21743474; DOI=10.1038/nature10158;
RG The Potato Genome Sequencing Consortium;
RT "Genome sequence and analysis of the tuber crop potato.";
RL Nature 475:189-195(2011).
RN [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400067146}
RP IDENTIFICATION.
RC STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400067146};
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR AlphaFoldDB; M1CGS3; -.
DR PaxDb; 4113-PGSC0003DMT400067146; -.
DR EnsemblPlants; PGSC0003DMT400067146; PGSC0003DMT400067146; PGSC0003DMG400026104.
DR Gramene; PGSC0003DMT400067146; PGSC0003DMT400067146; PGSC0003DMG400026104.
DR eggNOG; ENOG502R41B; Eukaryota.
DR HOGENOM; CLU_561904_0_0_1; -.
DR InParanoid; M1CGS3; -.
DR Proteomes; UP000011115; Unassembled WGS sequence.
DR ExpressionAtlas; M1CGS3; baseline.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11017:SF600; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE-RELATED; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000011115};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 241..403
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 182..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 486 AA; 55308 MW; 7DDC666493F1F304 CRC64;
MGINSTDYNL IIVGKYPTSF LSQEQVNIGE WIIYNDESLT NFLRVPDDYI DQIKLTILEI
YVRKEPKTSQ QRSPLSVDVH PRLENRNSVD GFPITQSTDF PNMTHYQNIL TDRYDFDLNE
TINESDCGLP QQDRNIAPSY GLDNYFGQSS HFEMTENVGT SSNFHVSPTF DADDCRENIT
QDEPIDPVNI DDRDLQNYVS PSASDSDDLP NAEELGDNVP FEASSDDDFL MPNWAASIVG
LGPSTINLQS EKSLEAMKVK GEKKNVKRFL HGFPERIEPN WKYDAFLSFR ELLKAIEESR
IAIIVFSENY ASSKWCLEEL TKIMDCVEKK GQEAIPIFHN VDPSDLRRQI SADEKYLVGI
ESRTGGVELL LKVGLGGVRF VGIWGMGKTT VARKIFDNIS NQFQGSCFLA NVREDSKKHG
MKHLQMTLLS RILHEKSMNI PSFYEGADMI KRKLCLRKVL IVFDDVDDDH QLEYLVGKND
WFGDGS
//
