ID M1GAX5_9ENTO Unreviewed; 879 AA.
AC M1GAX5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107};
DE Flags: Fragment;
OS Poliovirus 2.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Picornavirales; Picornaviridae; Ensavirinae; Enterovirus; Enterovirus C.
OX NCBI_TaxID=12083 {ECO:0000313|EMBL:AGA12478.1};
RN [1] {ECO:0000313|EMBL:AGA12478.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NIE0811462 {ECO:0000313|EMBL:AGA12478.1};
RX PubMed=23408630; DOI=10.1128/JVI.02954-12;
RA Burns C.C., Shaw J., Jorba J., Bukbuk D., Adu F., Gumede N., Pate M.A.,
RA Abanida E.A., Gasasira A., Iber J., Chen Q., Vincent A., Chenoweth P.,
RA Henderson E., Wannemuehler K., Naeem A., Umami R.N., Nishimura Y.,
RA Shimizu H., Baba M., Adeniji A., Williams A.J., Kilpatrick D.R.,
RA Oberste M.S., Wassilak S.G., Tomori O., Pallansch M.A., Kew O.;
RT "Multiple Independent Emergences of Type 2 Vaccine-Derived Polioviruses
RT during a Large Outbreak in Northern Nigeria.";
RL J. Virol. 87:4907-4922(2013).
CC -!- SUBUNIT: Interacts with capsid protein VP1 and capsid protein VP3 to
CC form heterotrimeric protomers. {ECO:0000256|ARBA:ARBA00011474}.
CC -!- SIMILARITY: Belongs to the picornaviruses polyprotein family.
CC {ECO:0000256|ARBA:ARBA00008303}.
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DR EMBL; JX275101; AGA12478.1; -; Genomic_RNA.
DR GO; GO:0019028; C:viral capsid; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0044694; P:pore-mediated entry of viral genome into host cell; IEA:UniProtKB-KW.
DR GO; GO:0039657; P:suppression by virus of host gene expression; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR CDD; cd00205; rhv_like; 3.
DR Gene3D; 2.60.120.20; -; 3.
DR InterPro; IPR003138; Pico_P1A.
DR InterPro; IPR001676; Picornavirus_capsid.
DR InterPro; IPR033703; Rhv-like.
DR InterPro; IPR029053; Viral_coat.
DR Pfam; PF02226; Pico_P1A; 1.
DR Pfam; PF00073; Rhv; 3.
DR SUPFAM; SSF88633; Positive stranded ssRNA viruses; 2.
PE 3: Inferred from homology;
KW Capsid protein {ECO:0000256|ARBA:ARBA00022561};
KW Eukaryotic host gene expression shutoff by virus
KW {ECO:0000256|ARBA:ARBA00023247};
KW Eukaryotic host translation shutoff by virus
KW {ECO:0000256|ARBA:ARBA00022809};
KW Host gene expression shutoff by virus {ECO:0000256|ARBA:ARBA00022995};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Myristate {ECO:0000256|ARBA:ARBA00022707};
KW Pore-mediated penetration of viral genome into host cell
KW {ECO:0000256|ARBA:ARBA00023255};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Viral penetration into host cytoplasm {ECO:0000256|ARBA:ARBA00022595};
KW Virion {ECO:0000256|ARBA:ARBA00022561};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT DOMAIN 93..306
FT /note="Picornavirus capsid"
FT /evidence="ECO:0000259|Pfam:PF00073"
FT DOMAIN 369..527
FT /note="Picornavirus capsid"
FT /evidence="ECO:0000259|Pfam:PF00073"
FT DOMAIN 636..796
FT /note="Picornavirus capsid"
FT /evidence="ECO:0000259|Pfam:PF00073"
FT REGION 596..615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 596..611
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 879
FT /evidence="ECO:0000313|EMBL:AGA12478.1"
SQ SEQUENCE 879 AA; 97125 MW; 4A0427575926C49A CRC64;
MGAQVSSQKV GAHENSNRAY GGSTINYTTI NYYRDSASNA ASKQDFAQDP SKFTEPIKDV
LIKTAPMLNS PNIEACGYSD RVMQLTLGNS TITTQEAANS VVAYGRWPEY IRDTEANPVD
QPTEPDVAAC RFYTLDTVTW RKESRGWWWK LPDALKDMGL FGQNMFYHYL GRAGYTVHVQ
CNASKFHQGA LGVFAVPEMC LAGDSTTHMF TKYENANPGE KGGEFKGSFT LDTNATNPAR
NFCPVDYLFG SGVLVGNAFV YPHQIINLRT NNCATLVLPY VNSLSIDSMT KHNNWGIAIL
PLAPLDFATE SSTEIPITLT IAPMCCEFNG LRNITVPRTQ GLPVLNTPGS NQYLTADNYQ
SPCAIPEFDV TPPIDIPGEV RNMMELAEID TMIPLNLTTQ RKNTMDMYRV ELSDSAHSDT
PIMCLSLSPA SDPRLAHTML GEILNYYTHW AGSLKFTFLF CGSMMATGKL LVSYAPPGAE
APKSRKEAML GTHVIWDIGL QSSCTMVVPW ISNTTYRQTI NDSFTEGGYI SMFYQTRVVV
PLSTPRKMDI LGFVSACNDF SVRLLRDTTH ISQEAMPQGI GDMIEGAVEG ITKNTLIPPA
STNNLPDTKS SGPAHSKEIP ALTAVETGAT NPLVPSDTVQ TRHVIQRRTR SESTVESFFA
RGACVAIIEV DNDAPTKRAS RLFSVWKITY KDTVQLRRKL EFFTYSRFDM EFTFVITSNY
TDANNGHALN QVYQIMYIPP GAPIPGKWND YTWQTSSNPS VFYTYGAPPA RISVPYVGIA
NAYSHFYDGF AKVPLAGQAS TEGDSLYGAA SLNDFGSLAV RVVNDHNPTR LTSKIRVYMK
PKHVRVWCPR PPRAVPYFGP GVDYKDGLTP LPEKGLTTY
//
