ID M1HMP9_9PHYC Unreviewed; 323 AA.
AC M1HMP9;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 13-SEP-2023, entry version 22.
DE RecName: Full=aspartate carbamoyltransferase {ECO:0000256|ARBA:ARBA00013008};
DE EC=2.1.3.2 {ECO:0000256|ARBA:ARBA00013008};
GN Name=CviKI_181R {ECO:0000313|EMBL:AGE51434.1};
GN ORFNames=PBCVCviKI_181R {ECO:0000313|EMBL:AGE51434.1};
OS Paramecium bursaria Chlorella virus CviKI.
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC Algavirales; Phycodnaviridae; Chlorovirus.
OX NCBI_TaxID=1278253 {ECO:0000313|EMBL:AGE51434.1, ECO:0000313|Proteomes:UP000246654};
RN [1] {ECO:0000313|EMBL:AGE51434.1, ECO:0000313|Proteomes:UP000246654}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Jeanniard A., Dunigan D.D., Gurnon J.R., Agarkova I., Kang M., Vitek J.,
RA Duncan G., McClung O.W., Larsen M., Claverie J.-M., Van Etten J.L.,
RA Blanc G.;
RT "Towards defining the chloroviruses: a genomic journey through a genus of
RT large DNA viruses.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-
CC aspartate + phosphate; Xref=Rhea:RHEA:20013, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29991, ChEBI:CHEBI:32814, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:58228; EC=2.1.3.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001363};
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC (S)-dihydroorotate from bicarbonate: step 2/3.
CC {ECO:0000256|ARBA:ARBA00004852}.
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DR EMBL; JX997162; AGE51434.1; -; Genomic_DNA.
DR UniPathway; UPA00070; UER00116.
DR Proteomes; UP000246654; Genome.
DR GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR GO; GO:0004070; F:aspartate carbamoyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.1370; Aspartate/ornithine carbamoyltransferase; 2.
DR InterPro; IPR006132; Asp/Orn_carbamoyltranf_P-bd.
DR InterPro; IPR006130; Asp/Orn_carbamoylTrfase.
DR InterPro; IPR036901; Asp/Orn_carbamoylTrfase_sf.
DR InterPro; IPR002082; Asp_carbamoyltransf.
DR InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn-bd.
DR NCBIfam; TIGR00670; asp_carb_tr; 1.
DR PANTHER; PTHR45753:SF6; ASPARTATE CARBAMOYLTRANSFERASE; 1.
DR PANTHER; PTHR45753; ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL; 1.
DR Pfam; PF00185; OTCace; 1.
DR Pfam; PF02729; OTCace_N; 1.
DR PRINTS; PR00100; AOTCASE.
DR PRINTS; PR00101; ATCASE.
DR SUPFAM; SSF53671; Aspartate/ornithine carbamoyltransferase; 1.
DR PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1.
PE 4: Predicted;
KW Pyrimidine biosynthesis {ECO:0000256|ARBA:ARBA00022975};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 24..160
FT /note="Aspartate/ornithine carbamoyltransferase carbamoyl-P
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02729"
FT DOMAIN 168..317
FT /note="Aspartate/ornithine carbamoyltransferase Asp/Orn-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF00185"
SQ SEQUENCE 323 AA; 36825 MW; 3A2E0BAAC6F6D1D6 CRC64;
MIIPTLTPGV ENFNAPVWFR DPVKHIVKSQ QFSKQTVQEL CILASEFKNV RNDSLRGKKM
LTYFEEPSTR TRLSFESAMY DLGGYVMSVE NAVNSSKAKG ETIEDTVRTI ERYADVFVIR
SNMAGTAEKA ARVSGIPVIN AGDGAGQHPT QALLDVYTIY DKFGDLNDLT VVVVGDLLYS
RTVHSLVYML SLFKVRMIFV APTECQMKYD LKNYLQDVGV VYEESNDLES VSKIADVVYM
TRIQKERFTD RPDDYDKCVG KYIMSKMIVE QMKQSSIIMH PLPRVDEISP DVDTNHRAVY
FDQVERGLEM RKALLFSIFY NAF
//
