ID M1MPQ1_9CLOT Unreviewed; 2759 AA.
AC M1MPQ1;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Amino acid adenylation domain protein {ECO:0000313|EMBL:AGF58188.1};
DE EC=5.1.1.13 {ECO:0000313|EMBL:AGF58188.1};
GN ORFNames=Cspa_c44350 {ECO:0000313|EMBL:AGF58188.1};
OS Clostridium saccharoperbutylacetonicum N1-4(HMT).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=931276 {ECO:0000313|EMBL:AGF58188.1, ECO:0000313|Proteomes:UP000011728};
RN [1] {ECO:0000313|EMBL:AGF58188.1, ECO:0000313|Proteomes:UP000011728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=N1-4(HMT) {ECO:0000313|Proteomes:UP000011728};
RA Poehlein A., Daniel R.;
RT "Genome sequence of Clostridium saccharoperbutylacetonicum N1-4(HMT).";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP004121; AGF58188.1; -; Genomic_DNA.
DR RefSeq; WP_015394499.1; NC_020291.1.
DR STRING; 36745.CLSAP_42070; -.
DR KEGG; csr:Cspa_c44350; -.
DR PATRIC; fig|931276.5.peg.4468; -.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_000022_11_0_9; -.
DR Proteomes; UP000011728; Chromosome.
DR GO; GO:0047689; F:aspartate racemase activity; IEA:UniProtKB-EC.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd19543; DCL_NRPS; 1.
DR CDD; cd19534; E_NRPS; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3.
DR Gene3D; 1.10.287.490; Helix hairpin bin; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020459; AMP-binding.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45398; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR PANTHER; PTHR45398:SF1; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 3.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF00975; Thioesterase; 1.
DR PRINTS; PR00154; AMPBINDING.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 6.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Isomerase {ECO:0000313|EMBL:AGF58188.1};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000011728}.
FT DOMAIN 937..1011
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2436..2511
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2759 AA; 318592 MW; C882A52442DAE81A CRC64;
MKYELTHAQR RILNADSLYQ NSSISNIGGI CYVPGDVDFK TLGKAIAGVV KKNEIFQFEF
KKDNGQVYQE QNEIKQNEIE FIDFNNDKSK FNKWSRQFFD ESMSVSDKFL YKFALFKLDD
KRKGYLAKCH HIISDGYSLA TIGKQVGKIY DNLLNIRESE IITVPYSEYI KSERDYLQSE
KFLRDKEFWN EEFSNLNEEF LFKETYDSRG NSYKYKISKE LIDKLHKLLS ENNISRSTFF
MSLLYLYIYK QTGEKDIVIG MPVYNRISKR MREAIGMFVS TVPVNFKINN ELNFKDFIKE
LNGKLRSCYK HQSYPYNVLV NDLKLPAKGY DGLFKIVFNY YNDSFRYPMN NSEIQVEEIT
SKQVGVPLNL ILKDFSESNL ELEFQYRISE FSENEIKIMC KCINNMLEQL VDNIYICVKD
LKLVDRTEEK VLLKDFNVTN FPYNKVTTIK ELFEEQVEKT PNNIAVVYRN KKLTYKELNE
RANSLARFLI GKGVKAETVV GIMVDRSLEM LIGIIGILKA GGAYLPIDPE YPDDRIKYIL
KDSKTKILLT QDELLVTVNY FGEVISLDDS SVYEMENSNV NIKGNSNDLA YVIYTSGTTG
KPKGVMVEQE SLVNLCIWHN EYYEVTEKDR ATKYAGFGFD ASVWEIFPYI IAGAALYIID
KTIMLDKFSL NKYYEQNQIT ISFLPTQMCE EFMNLENKYL RKLLTGADKL KVFKKQTYEL
VNNYGPTENA VVTTSFKVNK NYNNIPIGKP INNSKIYILG IDNGLMPIGV VGELCVSGDG
IARGYINRDD LTKEKFVDNP FEKGLKMYRT GDLARWLPDG NIEYLGRIDN QIKIRGFRIE
IGEIENQFLK IEGINEVVVI GKKDKNENTY LCAYVSMEKE LEVAKLKEEL AKELPDYMLP
KYIIKIDRLP LTPNGKVDKK ALPEIDISEI VNTEYKSPRN EIEDALVEAW KEVLGIDKIG
INDNYYELGG DSIKSIQIVS ALHNSGIKLE IKDLMKYQTI EELSKRVKYN QVKVEQGIIE
GEVYFSPIQK WFLDNNFANQ NHFNQAFSFD IKNGIDEQIL KQAFIEIMKH HDALRMSYVK
KDNKINQINR NIEDIQNMFT LNIYNIENEE NCEKEVEALS NKIQEGLSLE KGILVKLGVF
KTNKGDHLLI AIHHMIIDGV SWRILLEDLE KAYKSIKCGK QVVLPQKTTS YKAWVKNLYE
YSNSKELHRE KEYWSNLESV DIKELPKDFN KSKSIVGNSK NITISLSRGE TERLLRKTNK
AYNTDINDIL LCSLGLAVKQ WSKNDEILIG LEGHGREEII EEVSINRTIG WFTSTCPVIL
DMKNSDDIGY SIKYTKETLR HIPNKGVGYG ILKYLTNFEN KKDISLKLNP EIGFNYLGEF
GKNSDETLFK FSDLSSGKAI SEQNEKINSI EINGFVIDGE LKFIINYSIE EYKQETIEKL
TELYRKKLLE IIEHCELIKE VERTPWDYGD KELKIEDLNK IISYKKEITK IHSLTPMQEG
ILYNSIIDSD SHAYFEQSVF TVTGLLDIEI LNKAFNKLIE KYEILRTTFL NENISKPKQV
VLGKRELKIY YNDISDLAVD KEEYLEEFKN KDKDRGFDLK NDCLIRVSVI KTGKDIFKII
YSFHHIIMDG WCLGIIIKDV IDMYRLISKN KEVMFDETEE YSGYLEWLDK QDKEYQLNYW
SNYLSEYEQE VSIPKFNTEV KNFINEEEKI IISEDLTCKL KKMAEMNSIT LNSVIQTAWG
ILLQKYNDAN DVVFGSVVSG RPSEINSIEN IVGLFINTVP VRVKAEDNAE FIDIAKKMNE
DFIEVNSHSY CSLAEIQALT SMKTNLINNI VAFENYPIDR DMLNSYISDE SGIKIINDVE
MFEQINYDFA LLVIPGDNLT FKIKYNGNVY SKETIKQIIN NLYTELNCVI GNPNIKLRDI
DILSSDEKNK LLKEYNNTRM DIPNDATIID LFEKQVEKTP NNIVAVYKEK KLTYRELNEK
SNSLARILIK KGVKAETIVG IMVDRSLEML IGIMGVLKAG GAYLPIDSEY PEDRIKYMLE
DSRARILLTQ NKLLKNINYE GETIDLEAAN LYEKEKSNIR IVRKVNDLAY VIYTSGTTGK
PKGVMVEQKA LVNLCLWHNE YYEVTEIDRA AKYAGFGFDA SVWEIFPYII SGAALYIVEK
AIMLDKDQLN KYYEKNQITI GFLPTQMCEE FINLKNKSLR KLLTGADKLN YYKEQTYELI
NNYGPTENAV VTTSFKVDKN YKNIPIGKPI SNSKIYILGR NNSLMPIGAT GELCVSGDGL
ARGYLNRVEL TREKFVDNPF EEGTKIYRTG DLARWLPNGN IEYLGRIDNQ VKIRGFRIEI
GEIENQLLKI EGINGAVVIA NGNDNLDKQL LAYVAAEKEL EVASIKDQLS RELPVYMIPN
HIIQMDKLPI TQNGKVNRKA LAELAVTQMS EREYEPPRNE IEDKLVAIWE DLLNVKKVGI
DDNFYELGGH SLKGALLKSK IKENLNIEIP LNVLFAKLTI RELSECIDKG EYACEDYIVF
NEQAKKTVIC FPPYMAYGFF YNGIAERVKD YKMYSYNFIY SENLIEDYVN RILSLSDAKK
IVFFGWSAGG KLAVEIADKM NKMGYDVTDV VLLDTMPLNF NKISADDNNS HKISKEREAQ
FAAENMAEVL ERVSQDMPKY LEFIENDNEA EEKMTKYLEY YNSPSTVKDV TSKLHLILIP
DECREEGDLK NEEIHAGWKQ ISKDVITYKG FGRHEDMLND ENIDKNANVI FNIFEKIEF
//
