ID   M1Q7U8_9REOV            Unreviewed;       188 AA.
AC   M1Q7U8;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=NSP4 {ECO:0000313|EMBL:AGF92018.1};
DE   Flags: Fragment;
OS   Rotavirus A.
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Sedoreoviridae; Rotavirus.
OX   NCBI_TaxID=28875 {ECO:0000313|EMBL:AGF92018.1, ECO:0000313|Proteomes:UP000222939};
RN   [1] {ECO:0000313|EMBL:AGF92018.1, ECO:0000313|Proteomes:UP000222939}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PA3/2004 {ECO:0000313|EMBL:AGF92018.1,
RC   ECO:0000313|Proteomes:UP000222939};
RX   PubMed=24077298; DOI=10.1099/vir.0.056788-0;
RA   Giammanco G.M., Bonura F., Zeller M., Heylen E., Van Ranst M., Martella V.,
RA   Banyai K., Matthijnssens J., De Grazia S.;
RT   "Evolution of DS-1-like human G2P[4] rotaviruses assessed by complete
RT   genome analyses.";
RL   J. Gen. Virol. 95:91-109(2014).
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DR   EMBL; KC178747; AGF92018.1; -; mRNA.
DR   Proteomes; UP000222939; Genome.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.430; -; 1.
DR   HAMAP; MF_04091; ROTA_NSP4; 1.
DR   InterPro; IPR002107; Rotavirus_NSP4.
DR   Pfam; PF01452; Rota_NSP4; 1.
DR   SUPFAM; SSF58030; Rotavirus nonstructural proteins; 1.
PE   2: Evidence at transcript level;
KW   Activation of host autophagy by virus {ECO:0000256|ARBA:ARBA00023050};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Enterotoxin {ECO:0000256|ARBA:ARBA00022861};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00023050};
KW   Toxin {ECO:0000256|ARBA:ARBA00022656}.
FT   COILED          98..125
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AGF92018.1"
SQ   SEQUENCE   188 AA;  21765 MW;  24B13D929B1B7CEE CRC64;
     LLKVLFRESA CGKMEKFTDL NYTLSVITLM NSTLHTILED PGMAYFPYIA SVLTVLFTLH
     KASIPTMKIA LKTSKCSYKV VKYCIVTILN TLLKLAGYKE QITTKDEIEK QMDRVVKEMR
     RQLEMIDKLT TREIEQVELL KRIYDKLIVR STDGIDMTKE INQKNVRTLE EWESGKNPYE
     PKEVTAAM
//