ID M1RN52_9INFA Unreviewed; 274 AA.
AC M1RN52;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=RNA-directed RNA polymerase catalytic subunit {ECO:0000256|ARBA:ARBA00020035};
DE EC=2.7.7.48 {ECO:0000256|ARBA:ARBA00012494};
DE Flags: Fragment;
GN Name=PB1 {ECO:0000313|EMBL:AGG12469.1};
OS Influenza A virus (A/mallard/Czech Republic/15902-9K/2009).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus;
OC Alphainfluenzavirus influenzae; Influenza A virus.
OX NCBI_TaxID=1293286 {ECO:0000313|EMBL:AGG12469.1};
RN [1] {ECO:0000313|EMBL:AGG12469.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A/mallard/Czech Republic/15902-9K/2009
RC {ECO:0000313|EMBL:AGG12469.1};
RX PubMed=25075739;
RA Nagy A., Cernikova L., Jirincova H., Havlickova M., Hornickova J.;
RT "Local-scale diversity and between-year 'frozen evolution' of avian
RT influenza a viruses in nature.";
RL PLoS ONE 9:E103053-E103053(2014).
CC -!- FUNCTION: RNA-dependent RNA polymerase which is responsible for
CC replication and transcription of virus RNA segments. The transcription
CC of viral mRNAs occurs by a unique mechanism called cap-snatching. 5'
CC methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides
CC by PA. In turn, these short capped RNAs are used as primers by PB1 for
CC transcription of viral mRNAs. During virus replication, PB1 initiates
CC RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn
CC serves as a template for the production of more vRNAs.
CC {ECO:0000256|ARBA:ARBA00002148}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Host
CC cytoplasm {ECO:0000256|ARBA:ARBA00004192}. Host nucleus
CC {ECO:0000256|ARBA:ARBA00004147}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KC599278; AGG12469.1; -; Viral_cRNA.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0039523; P:suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity; IEA:UniProtKB-KW.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR GO; GO:0019083; P:viral transcription; IEA:UniProtKB-KW.
DR Gene3D; 6.10.140.720; -; 1.
DR InterPro; IPR001407; RNA_pol_PB1_influenza.
DR Pfam; PF00602; Flu_PB1; 1.
PE 4: Predicted;
KW Eukaryotic host gene expression shutoff by virus
KW {ECO:0000256|ARBA:ARBA00023103};
KW Eukaryotic host transcription shutoff by virus
KW {ECO:0000256|ARBA:ARBA00022731};
KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW Host gene expression shutoff by virus {ECO:0000256|ARBA:ARBA00023103};
KW Host nucleus {ECO:0000256|ARBA:ARBA00022562};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Inhibition of host RNA polymerase II by virus
KW {ECO:0000256|ARBA:ARBA00023103};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Viral transcription {ECO:0000256|ARBA:ARBA00023314}.
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AGG12469.1"
SQ SEQUENCE 274 AA; 31533 MW; 9D5F709B11DEB18E CRC64;
INRTGTFEFT SFFYRYGFVA NFSMELPSFG VSGINESADM SIGVTVIKNN MINNDLGPAT
AQMALQLFIK DYRYTYRCHR GDTQIQTRRS FELKKLWEQT RSKAGLLVSD GGPNLYNIRN
LHIPEVCLKW ELMDEDYQGR LCNPLNPFVS HKEIESVNNA VVMPAHGPAK SMEYDAVATT
HSWIPKRNRS ILNTSQRGIL EDEQMYQKCC SLFEKFFPSS SYRRPVGISS MVEAMVSRAR
IDARIDFESG RIKKEEFAEI MKICSTIEEL RRQK
//
