ID M1UWL9_CYAM1 Unreviewed; 732 AA.
AC M1UWL9;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Similar to hedgehog protein {ECO:0000313|EMBL:BAM82656.1};
GN ORFNames=CYME_CMR506C {ECO:0000313|EMBL:BAM82656.1};
OS Cyanidioschyzon merolae (strain NIES-3377 / 10D) (Unicellular red alga).
OC Eukaryota; Rhodophyta; Bangiophyceae; Cyanidiales; Cyanidiaceae;
OC Cyanidioschyzon.
OX NCBI_TaxID=280699 {ECO:0000313|EMBL:BAM82656.1, ECO:0000313|Proteomes:UP000007014};
RN [1] {ECO:0000313|EMBL:BAM82656.1, ECO:0000313|Proteomes:UP000007014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=10D {ECO:0000313|EMBL:BAM82656.1,
RC ECO:0000313|Proteomes:UP000007014};
RX PubMed=15071595; DOI=10.1038/nature02398;
RA Matsuzaki M., Misumi O., Shin-i T., Maruyama S., Takahara M.,
RA Miyagishima S., Mori T., Nishida K., Yagisawa F., Nishida K., Yoshida Y.,
RA Nishimura Y., Nakao S., Kobayashi T., Momoyama Y., Higashiyama T.,
RA Minoda A., Sano M., Nomoto H., Oishi K., Hayashi H., Ohta F., Nishizaka S.,
RA Haga S., Miura S., Morishita T., Kabeya Y., Terasawa K., Suzuki Y.,
RA Ishii Y., Asakawa S., Takano H., Ohta N., Kuroiwa H., Tanaka K.,
RA Shimizu N., Sugano S., Sato N., Nozaki H., Ogasawara N., Kohara Y.,
RA Kuroiwa T.;
RT "Genome sequence of the ultrasmall unicellular red alga Cyanidioschyzon
RT merolae 10D.";
RL Nature 428:653-657(2004).
RN [2] {ECO:0000313|EMBL:BAM82656.1, ECO:0000313|Proteomes:UP000007014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=10D {ECO:0000313|EMBL:BAM82656.1,
RC ECO:0000313|Proteomes:UP000007014};
RX PubMed=17623057; DOI=10.1186/1741-7007-5-28;
RA Nozaki H., Takano H., Misumi O., Terasawa K., Matsuzaki M., Maruyama S.,
RA Nishida K., Yagisawa F., Yoshida Y., Fujiwara T., Takio S., Tamura K.,
RA Chung S.J., Nakamura S., Kuroiwa H., Tanaka K., Sato N., Kuroiwa T.;
RT "A 100%-complete sequence reveals unusually simple genomic features in the
RT hot-spring red alga Cyanidioschyzon merolae.";
RL BMC Biol. 5:28-28(2007).
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DR EMBL; AP006500; BAM82656.1; -; Genomic_DNA.
DR RefSeq; XP_005538692.1; XM_005538635.1.
DR AlphaFoldDB; M1UWL9; -.
DR EnsemblPlants; CMR506CT; CMR506CT; CMR506C.
DR GeneID; 16996733; -.
DR Gramene; CMR506CT; CMR506CT; CMR506C.
DR KEGG; cme:CYME_CMR506C; -.
DR eggNOG; KOG3638; Eukaryota.
DR HOGENOM; CLU_380095_0_0_1; -.
DR OrthoDB; 3035164at2759; -.
DR Proteomes; UP000007014; Chromosome 18.
DR GO; GO:0007267; P:cell-cell signaling; IEA:InterPro.
DR GO; GO:0016539; P:intein-mediated protein splicing; IEA:InterPro.
DR GO; GO:0016540; P:protein autoprocessing; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00081; Hint; 1.
DR Gene3D; 2.170.16.10; Hedgehog/Intein (Hint) domain; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR InterPro; IPR001657; Hedgehog.
DR InterPro; IPR001767; Hedgehog_Hint.
DR InterPro; IPR003586; Hint_dom_C.
DR InterPro; IPR003587; Hint_dom_N.
DR InterPro; IPR036844; Hint_dom_sf.
DR InterPro; IPR006141; Intein_N.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR PANTHER; PTHR11889; HEDGEHOG; 1.
DR PANTHER; PTHR11889:SF31; PROTEIN HEDGEHOG; 1.
DR Pfam; PF01079; Hint; 1.
DR Pfam; PF13418; Kelch_4; 4.
DR PRINTS; PR00632; SONICHHOG.
DR SMART; SM00305; HintC; 1.
DR SMART; SM00306; HintN; 1.
DR SUPFAM; SSF51294; Hedgehog/intein (Hint) domain; 1.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR PROSITE; PS50817; INTEIN_N_TER; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007014};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..732
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004018090"
FT DOMAIN 489..626
FT /note="Hint"
FT /evidence="ECO:0000259|SMART:SM00306"
FT DOMAIN 625..670
FT /note="Hint"
FT /evidence="ECO:0000259|SMART:SM00305"
FT REGION 450..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..466
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 732 AA; 79286 MW; F3DC1887D592E962 CRC64;
MRKRYFSIVR LLVVVLVVSS THTVRGVLSS EDTFLWTWIG GSNSTGSSGS YGVQGVPNTS
NVPPARYGAV FWTGADGVLW LFGGGSDLRD VFGDLWNYNL STFSWTWVGG SASLNSAGVY
GSRGVPNKSN NPPSRTESAS WSDSYGNLWL YGGWNFISAY SDLWMYNVSS GEWTWVQGSN
ETNVPPTYGP LGKSASSNTP GGRYQPATWV GLDGQFYLFG GFNPSGSTYG DLWQYNPANN
EWSWIGGTQQ QNPSGSYGKF RQASPSNYPA GRLGATSWRD LDGNFWLFGG FGQIETFGRL
NDLWLYNISS REWTWMSGND SVGLDGEVYG EKGVPSSSNT PGYRSFSSGF LDSTNTLYLF
GGVSRAVCND LWTFNITSLE WTWVDGDNTT DGAYSYGELN KTSNTTLPPP RYGAVLWDTY
QNDPVLFGGL GNSGLLNDLF TLYIATPTPA PTPTPTPTPT PMASPTPSVT AEPSATTNVT
QTAVGEGSAV CFPADASVLI DGLGNHLQIS ELRSGMAVMG VNGRGQLVED SVLGWLHNEA
GATAEILAIK TLSGKQLRLT RQHLVYRMIE HSRDFYGMTT AFSCISQKQQ QQHQKHIRQS
LELDTSAVEA VFAEEISVGD ALLDVAAHLP DPVVAIETFV THNGLYAPLT RSGRFVVDGV
LVSCYGTYAS HAVAHAVLWP ARVNALRKVW GSGLGTEGIV GIMPYAERLY HIWTSAARVL
TEARISVVVA AC
//
