ID M1V4C9_CYAM1 Unreviewed; 597 AA.
AC M1V4C9;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=SAICAR synthetase {ECO:0000256|ARBA:ARBA00030409};
DE EC=4.1.1.21 {ECO:0000256|ARBA:ARBA00012329};
DE EC=6.3.2.6 {ECO:0000256|ARBA:ARBA00012217};
GN ORFNames=CYME_CME023C {ECO:0000313|EMBL:BAM79260.1};
OS Cyanidioschyzon merolae (strain NIES-3377 / 10D) (Unicellular red alga).
OC Eukaryota; Rhodophyta; Bangiophyceae; Cyanidiales; Cyanidiaceae;
OC Cyanidioschyzon.
OX NCBI_TaxID=280699 {ECO:0000313|EMBL:BAM79260.1, ECO:0000313|Proteomes:UP000007014};
RN [1] {ECO:0000313|EMBL:BAM79260.1, ECO:0000313|Proteomes:UP000007014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=10D {ECO:0000313|EMBL:BAM79260.1,
RC ECO:0000313|Proteomes:UP000007014};
RX PubMed=15071595; DOI=10.1038/nature02398;
RA Matsuzaki M., Misumi O., Shin-i T., Maruyama S., Takahara M.,
RA Miyagishima S., Mori T., Nishida K., Yagisawa F., Nishida K., Yoshida Y.,
RA Nishimura Y., Nakao S., Kobayashi T., Momoyama Y., Higashiyama T.,
RA Minoda A., Sano M., Nomoto H., Oishi K., Hayashi H., Ohta F., Nishizaka S.,
RA Haga S., Miura S., Morishita T., Kabeya Y., Terasawa K., Suzuki Y.,
RA Ishii Y., Asakawa S., Takano H., Ohta N., Kuroiwa H., Tanaka K.,
RA Shimizu N., Sugano S., Sato N., Nozaki H., Ogasawara N., Kohara Y.,
RA Kuroiwa T.;
RT "Genome sequence of the ultrasmall unicellular red alga Cyanidioschyzon
RT merolae 10D.";
RL Nature 428:653-657(2004).
RN [2] {ECO:0000313|EMBL:BAM79260.1, ECO:0000313|Proteomes:UP000007014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=10D {ECO:0000313|EMBL:BAM79260.1,
RC ECO:0000313|Proteomes:UP000007014};
RX PubMed=17623057; DOI=10.1186/1741-7007-5-28;
RA Nozaki H., Takano H., Misumi O., Terasawa K., Matsuzaki M., Maruyama S.,
RA Nishida K., Yagisawa F., Yoshida Y., Fujiwara T., Takio S., Tamura K.,
RA Chung S.J., Nakamura S., Kuroiwa H., Tanaka K., Sato N., Kuroiwa T.;
RT "A 100%-complete sequence reveals unusually simple genomic features in the
RT hot-spring red alga Cyanidioschyzon merolae.";
RL BMC Biol. 5:28-28(2007).
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-
CC phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.
CC {ECO:0000256|ARBA:ARBA00004672}.
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-
CC phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.
CC {ECO:0000256|ARBA:ARBA00004747}.
CC -!- SIMILARITY: Belongs to the SAICAR synthetase family.
CC {ECO:0000256|ARBA:ARBA00010190}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the SAICAR synthetase
CC family. {ECO:0000256|ARBA:ARBA00011020}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AP006487; BAM79260.1; -; Genomic_DNA.
DR RefSeq; XP_005535546.1; XM_005535489.1.
DR AlphaFoldDB; M1V4C9; -.
DR STRING; 280699.M1V4C9; -.
DR EnsemblPlants; CME023CT; CME023CT; CME023C.
DR GeneID; 16992816; -.
DR Gramene; CME023CT; CME023CT; CME023C.
DR KEGG; cme:CYME_CME023C; -.
DR eggNOG; KOG2835; Eukaryota.
DR HOGENOM; CLU_457391_0_0_1; -.
DR OMA; VISCPPY; -.
DR OrthoDB; 605at2759; -.
DR UniPathway; UPA00074; UER00130.
DR Proteomes; UP000007014; Chromosome 5.
DR GO; GO:0043727; F:5-amino-4-imidazole carboxylate lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004638; F:phosphoribosylaminoimidazole carboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0004639; F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd01414; SAICAR_synt_Sc; 1.
DR Gene3D; 3.40.50.1970; -; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR HAMAP; MF_00137; SAICAR_synth; 1.
DR InterPro; IPR000031; PurE_dom.
DR InterPro; IPR028923; SAICAR_synt/ADE2_N.
DR InterPro; IPR018236; SAICAR_synthetase_CS.
DR PANTHER; PTHR43700; PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE; 1.
DR PANTHER; PTHR43700:SF1; PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE; 1.
DR Pfam; PF00731; AIRC; 1.
DR Pfam; PF01259; SAICAR_synt; 1.
DR SMART; SM01001; AIRC; 1.
DR SUPFAM; SSF52255; N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE); 1.
DR SUPFAM; SSF56104; SAICAR synthase-like; 1.
DR PROSITE; PS01057; SAICAR_SYNTHETASE_1; 1.
DR PROSITE; PS01058; SAICAR_SYNTHETASE_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Purine biosynthesis {ECO:0000256|ARBA:ARBA00022755};
KW Reference proteome {ECO:0000313|Proteomes:UP000007014}.
FT DOMAIN 95..242
FT /note="PurE"
FT /evidence="ECO:0000259|SMART:SM01001"
SQ SEQUENCE 597 AA; 65759 MW; 7F100DD4E0C45AFD CRC64;
MFGFVTSTSS PLGLRFSSFH SNTITCFHHV SSGKNQFGGT CRTANGAPAR LGSRRLAPPR
VLRTLNCSTM DLTAPVTSSG NNSIGDHSAQ GRLTPLVPIL MGSKADKKHC DQIAAACHRF
GLATEMHVLS AHKVPTRLLE VVGRLEADPR PKVYISVAGR SNALSGLLDG SVASPVIACP
PPSDAFGGAD IFSSLRMPGG IAPVVSLDPG NAALTAAKIL GIHDPLVRDR VRAFQKANRD
RLYVDDAEVA TSAYLADIQA AARENNVLVS TDGVLSALVQ QHAGTWRKKQ GKVRDQFYSD
AAKHMILVTT DRQSAFDRVL AAVPFKGAVL NLVSAWWFRR TEHIVPNHLI AVPHPNVTIA
KRCDPFPIEF VVRGYATGST STSLWKNYER GVREYCGIKL PDNLHKNQKL WMNLVTPTTK
EDIGDALISR QEIIDRGLMS AVDFDACAAY ALRLFEYGQQ VASEHGLILV DTKYEFGRDA
DGQICLIDEI HTPDSSRYWL ATSYEERIAS GKEPENIDKE ILRLWYRDHC DPYKDEKLPE
APLELVTELS RRYIQLYEMI TWDKFDLRLS TPSELQQALG PWFSGQGAKA NFTMSSP
//