ID M2NL55_9PSEU Unreviewed; 615 AA.
AC M2NL55;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=protein-glutamate O-methyltransferase {ECO:0000256|ARBA:ARBA00012534};
DE EC=2.1.1.80 {ECO:0000256|ARBA:ARBA00012534};
GN ORFNames=C791_7874 {ECO:0000313|EMBL:EMD22874.1};
OS Amycolatopsis azurea DSM 43854.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Amycolatopsis.
OX NCBI_TaxID=1238180 {ECO:0000313|EMBL:EMD22874.1, ECO:0000313|Proteomes:UP000014137};
RN [1] {ECO:0000313|EMBL:EMD22874.1, ECO:0000313|Proteomes:UP000014137}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43854 {ECO:0000313|EMBL:EMD22874.1,
RC ECO:0000313|Proteomes:UP000014137};
RA Khatri I., Kaur I., Subramanian S., Mayilraj S.;
RT "Genome assembly of Amycolatopsis azurea DSM 43854.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-
CC glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:24452, Rhea:RHEA-COMP:10208, Rhea:RHEA-COMP:10311,
CC ChEBI:CHEBI:29973, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:82795; EC=2.1.1.80;
CC Evidence={ECO:0000256|ARBA:ARBA00001541};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMD22874.1}.
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DR EMBL; ANMG01000085; EMD22874.1; -; Genomic_DNA.
DR RefSeq; WP_005166296.1; NZ_MUXN01000017.1.
DR AlphaFoldDB; M2NL55; -.
DR PATRIC; fig|1238180.3.peg.7347; -.
DR OrthoDB; 9816309at2; -.
DR Proteomes; UP000014137; Unassembled WGS sequence.
DR GO; GO:0008983; F:protein-glutamate O-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 1.10.155.10; Chemotaxis receptor methyltransferase CheR, N-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022642; CheR_C.
DR InterPro; IPR000780; CheR_MeTrfase.
DR InterPro; IPR022641; CheR_N.
DR InterPro; IPR036804; CheR_N_sf.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR24422; CHEMOTAXIS PROTEIN METHYLTRANSFERASE; 1.
DR PANTHER; PTHR24422:SF25; CHEMOTAXIS PROTEIN METHYLTRANSFERASE; 1.
DR Pfam; PF01739; CheR; 1.
DR Pfam; PF03705; CheR_N; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF13188; PAS_8; 1.
DR PRINTS; PR00996; CHERMTFRASE.
DR SMART; SM00138; MeTrc; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47757; Chemotaxis receptor methyltransferase CheR, N-terminal domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS50123; CHER; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:EMD22874.1};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EMD22874.1}.
FT DOMAIN 11..284
FT /note="CheR-type methyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS50123"
FT DOMAIN 502..544
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 466..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 615 AA; 69543 MW; 868B10B3EE342C27 CRC64;
MSAPEGGNDE DRDLETLLTF IRDSRGFDFT GYKRTSLARR IRKRMQTVKI DDYADYRDHL
EINSDEFQEL FNTILINVTS FFRDPEAWTY LRATVVPDLV KKVGPTEEIR LWSAGCSSGE
EAYSLAMIFA EYLGLEAATS RVKIYGTDVD EEALREARAG LYSAKALERL PEDLKNKYFE
PAGDLFAFSR DLRRRVIFGR HDITRDAPIS RVDLLSCRNT LMYFNIETQT KIIERFHFAL
NEGGHLFLGK AEMLLSDGAR FEIANMRNRV FTVRSGRVTT KAPRFDVWAD AGMRDTNRRR
LVSELALASS PDSVLGIDHD GAIALINGSA RLQFGLSLND VGKPFHELEI SYRPIELRSV
IDQAHGERRS IRINSVRRQK SENEAQYFDI IVRPLLTIDG EDIGAAITFI DTTEATRLQH
EVKRVQEDLA TAYAELQSTN AELETVNEEL QSSIEELETT NEELQSTNEE LETTNEELQS
TNEELETMNE EMRVRTTELD ETRVFFEGVL SSIEAGVVVL DGDLLVRSWN RGAEDLWGLR
SDEVYREDFF ALDFGLPTAG LRDAVEACNE TGEKGDRIEL DAVDRKGRSL VASIGCSPLH
GPGGGVVLLM EHSRN
//
