ID   M2Q776_9PSEU            Unreviewed;       393 AA.
AC   M2Q776;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   RecName: Full=HNH nuclease domain-containing protein {ECO:0000259|SMART:SM00507};
GN   ORFNames=C791_0729 {ECO:0000313|EMBL:EMD21922.1};
OS   Amycolatopsis azurea DSM 43854.
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Amycolatopsis.
OX   NCBI_TaxID=1238180 {ECO:0000313|EMBL:EMD21922.1, ECO:0000313|Proteomes:UP000014137};
RN   [1] {ECO:0000313|EMBL:EMD21922.1, ECO:0000313|Proteomes:UP000014137}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 43854 {ECO:0000313|EMBL:EMD21922.1,
RC   ECO:0000313|Proteomes:UP000014137};
RA   Khatri I., Kaur I., Subramanian S., Mayilraj S.;
RT   "Genome assembly of Amycolatopsis azurea DSM 43854.";
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the Rv1128c/1148c/1588c/1702c/1945/3466 family.
CC       {ECO:0000256|ARBA:ARBA00023450}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EMD21922.1}.
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DR   EMBL; ANMG01000112; EMD21922.1; -; Genomic_DNA.
DR   AlphaFoldDB; M2Q776; -.
DR   PATRIC; fig|1238180.3.peg.8380; -.
DR   Proteomes; UP000014137; Unassembled WGS sequence.
DR   GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00085; HNHc; 1.
DR   Gene3D; 1.10.30.50; -; 1.
DR   InterPro; IPR003870; DUF222.
DR   InterPro; IPR002711; HNH.
DR   InterPro; IPR003615; HNH_nuc.
DR   Pfam; PF02720; DUF222; 1.
DR   Pfam; PF01844; HNH; 1.
DR   SMART; SM00507; HNHc; 1.
PE   3: Inferred from homology;
FT   DOMAIN          302..354
FT                   /note="HNH nuclease"
FT                   /evidence="ECO:0000259|SMART:SM00507"
FT   REGION          142..161
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        146..161
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   393 AA;  43168 MW;  1E9F10026480D192 CRC64;
     MQQFLQVMRV ASAGLGQFLA EVESRGAKDL YGYGSTAAWF ADVARLSRGE AGPIVKRAIA
     LNPTRAVDGS EVPAVAPATA AVAAEGVIGE HRIEQILEIL KKIPADTSVE DRESAEKILA
     DLAREAGPRQ LADAEANLLA WLDPDGNEPK DPEPKQPRRE VTLERRRDGF WKLTGLLDDE
     LGARTAAALE AYAKPRPVDE FGQADLRMKC ERLGDAWAEL LDLAIACPDQ PGTSGYRTLV
     HVTIGLEELK TGIGKACLDF VGSMTAREAR MAACDCLMLP VVLNAAGEPL DVGRLRRFVT
     PGQRRALNIR DHGCAFPGCH RRPKNCHAHH IHHWADGGPT DLRNLVLLCG FHHRLIHHGD
     WQVHMATDGL PEFIPPQYLD PLRRSRRNTL HRA
//