ID   M2QIZ4_ENTHI            Unreviewed;       575 AA.
AC   M2QIZ4;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=RhoGAP domain containing protein {ECO:0000313|EMBL:EMD49344.1};
GN   ORFNames=EHI5A_114800 {ECO:0000313|EMBL:EMD49344.1};
OS   Entamoeba histolytica KU27.
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=885311 {ECO:0000313|EMBL:EMD49344.1, ECO:0000313|Proteomes:UP000011755};
RN   [1] {ECO:0000313|EMBL:EMD49344.1, ECO:0000313|Proteomes:UP000011755}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KU27 {ECO:0000313|EMBL:EMD49344.1,
RC   ECO:0000313|Proteomes:UP000011755};
RA   Hannick L., Zafar N., Lorenzi H., Ali I.A., Petri W.P., Caler E.;
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Rho GTPase-activating protein involved in the signal
CC       transduction pathway. {ECO:0000256|ARBA:ARBA00037092}.
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DR   EMBL; KB443857; EMD49344.1; -; Genomic_DNA.
DR   AlphaFoldDB; M2QIZ4; -.
DR   EnsemblProtists; EMD49344; EMD49344; EHI5A_114800.
DR   VEuPathDB; AmoebaDB:EHI5A_114800; -.
DR   Proteomes; UP000011755; Unassembled WGS sequence.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd00159; RhoGAP; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR45808; RHO GTPASE-ACTIVATING PROTEIN 68F; 1.
DR   PANTHER; PTHR45808:SF2; RHO GTPASE-ACTIVATING PROTEIN 68F; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
FT   DOMAIN          82..269
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          320..433
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          533..575
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        320..352
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        401..433
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        543..569
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   575 AA;  65664 MW;  373F53B279767D82 CRC64;
     MLVIYTNEKR LRPSFRMSLN DGIFVKLLNG RTIEDKKIDY GFVLIDKRDH SFVRIVFNNS
     KTHAQFYIPI ARECECFGCF GIPLDIAVQR GEWKVPLPIY RAIQYLLEGD NLQTDGLFRV
     SAAGSLLSQT RNRLDKGKDI DPSEFCDANV AAGIIKLYLR SLPDSLIPVE FSDKFMNIVR
     LEDPQQQIEQ IKEFIKTLPE PNLFVFKYLF MFLTKVMAES KINKMVASNI AIVFSPNLLF
     YEDSQDGLIL SKNVNDLIAK IVEHYNEICG TMEEFPGDFP KFNPQKEQVD HENFIIKKKN
     LILRKSVLFT DIGKKVGLKK ETAEEKKAKE EEIEKEKTKE EMEKKERERL TKSSNNLNVP
     ESSSSNSSLE KDDKSDDSSK SIQTPRGGLF DSIVNFPKNH LRPTPKEDKE ERKQGKEGKK
     EVLMKRKSMK QKSDPMEILN MRVGIIESQI QAIFQMMIEM NKTIDAIAIK NGITPIHEQV
     EKVPQPLDSF ISSESCVSDH SSCISDSKSH NSSKISEISI DVVASEPITP SISTPRVVEQ
     QSCKESSVEE KIPKRKVTKQ DESKKKRLSR VFGSK
//