ID   M2REP3_ENTHI            Unreviewed;       471 AA.
AC   M2REP3;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   22-FEB-2023, entry version 25.
DE   SubName: Full=Rho guanine nucleotide exchange factor, putative {ECO:0000313|EMBL:EMD48048.1};
GN   ORFNames=EHI5A_034550 {ECO:0000313|EMBL:EMD48048.1};
OS   Entamoeba histolytica KU27.
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=885311 {ECO:0000313|EMBL:EMD48048.1, ECO:0000313|Proteomes:UP000011755};
RN   [1] {ECO:0000313|EMBL:EMD48048.1, ECO:0000313|Proteomes:UP000011755}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KU27 {ECO:0000313|EMBL:EMD48048.1,
RC   ECO:0000313|Proteomes:UP000011755};
RA   Hannick L., Zafar N., Lorenzi H., Ali I.A., Petri W.P., Caler E.;
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KB444160; EMD48048.1; -; Genomic_DNA.
DR   AlphaFoldDB; M2REP3; -.
DR   EnsemblProtists; EMD48048; EMD48048; EHI5A_034550.
DR   VEuPathDB; AmoebaDB:EHI5A_034550; -.
DR   Proteomes; UP000011755; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR   PANTHER; PTHR12673:SF263; GRFA PROTEIN, PUTATIVE-RELATED; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   4: Predicted;
FT   DOMAIN          136..317
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          15..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   471 AA;  54698 MW;  25B012B69E09E2E0 CRC64;
     MLSVNCLDAY TSMPNLPTTF PKTTRNSTSP QMSLAKSGQL LHTNKAFRIP YRLIVKSHEN
     RNKSDDSSQI FITPRRSSTH TSNVEITQLT LQLRKLNALQ SRIDHKDVDI KILILFQSII
     RGYLTRRVFG IKLMTKRKAA LMEFLTTEES YSNRMNEVCK KIYKPLLTLS KNNRLLVEKA
     FSVYQEISVN SQLFCNIMND AMKNYTVFKN VSCHLLECVK YLSPYMIYVS DSENSIKAEK
     ELEKLSITTQ VLSIVNEGKL QNRRLSGLLQ EPSMRVMQYP MLIKEALKYT HPKHPDYSTL
     KEAYKIYYFF TTLINSRCKQ KDLLNEWGNL TGQPEINIKG RYCLGVFDLI PNGIVRRKSY
     KKMLVCNDII FIVVDNCKKS FIDLTEPQTS FTIEQSLNIN NTTIVQLKYP DILEITTNSE
     LISKKFMKIE ERDEAMKQIE ASVSDKFFDL TNTKQWITLF TRINKKFGNQ L
//