ID M2RTP0_ENTHI Unreviewed; 719 AA.
AC M2RTP0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=DnaJ domain containing protein {ECO:0000313|EMBL:EMD47890.1};
GN ORFNames=EHI5A_058160 {ECO:0000313|EMBL:EMD47890.1};
OS Entamoeba histolytica KU27.
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=885311 {ECO:0000313|EMBL:EMD47890.1, ECO:0000313|Proteomes:UP000011755};
RN [1] {ECO:0000313|EMBL:EMD47890.1, ECO:0000313|Proteomes:UP000011755}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KU27 {ECO:0000313|EMBL:EMD47890.1,
RC ECO:0000313|Proteomes:UP000011755};
RA Hannick L., Zafar N., Lorenzi H., Ali I.A., Petri W.P., Caler E.;
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KB444202; EMD47890.1; -; Genomic_DNA.
DR AlphaFoldDB; M2RTP0; -.
DR EnsemblProtists; EMD47890; EMD47890; EHI5A_058160.
DR VEuPathDB; AmoebaDB:EHI5A_058160; -.
DR Proteomes; UP000011755; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.10.287.110; DnaJ domain; 1.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 1.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR004179; Sec63-dom.
DR PANTHER; PTHR24075; SEC63 DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24075:SF0; TRANSLOCATION PROTEIN SEC63 HOMOLOG; 1.
DR Pfam; PF00226; DnaJ; 1.
DR Pfam; PF02889; Sec63; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SMART; SM00973; Sec63; 1.
DR SUPFAM; SSF46565; Chaperone J-domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
PE 4: Predicted;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 64..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 192..213
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 102..174
FT /note="J"
FT /evidence="ECO:0000259|PROSITE:PS50076"
FT REGION 691..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 421..448
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 704..719
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 719 AA; 83909 MW; 235EFF0ABA798026 CRC64;
MVEEKLQFDD QMFLIFITGF IGIIILIWAL YYLRKQRTIP TTFPCQCSKC QEKRKRMIIK
NHKITSSTIF QFIIIGILSY VFIHNIIKIN SSNIIAPQPT FDPYIILGIS STSTDKEIRS
AYRKLSLKYH PDKNKEEGAE EMFIQVTKAY ETLTDPSKLK AWKETGREED DKIETKGIGL
PIFLTLEKNR KLILGFYIII IVIVFPVSVW LMVKKCNKKD NNNLTIETNA IFMQLINSNL
NFPSMIEVVS LANEVREVVV IRPNDKNFLP VIQKKIKEEF IKKPTYNVPE AVKAQILIGA
HLSRLHEELP SYLRDDLDSI LEVIPTVLHG MVSVMMGKKN LNGIWQCIRL NAMITQACGE
NDDFLQLPDF NEGGKVFGKN MTFERITKMT PEERMNLINE KIDSIEVEKQ HKVIEPKKQR
SEVKKRNIES MKERVKRALD EKAIKEGKKP KFNTKDTDEH KTKEIQENIE KHENSIEENI
KPNDNQLVNE RRKQIINFFN YYPTNITFIV RAMSNTGTRK VIAGVPILVT INGYRYPRNE
NGEIVPQWKS KLDDILNREK EELPDEPDDA EELLKSTKED FDKEEDEIDP EIPDVEIVHE
PPKDVYVHNP YCPNTRLERW WFIITDVRNQ FVLNATHGYI PISELPFITK IYLPSPKEEG
SYVVLLHIIC DSYLHCEWAY PIKFTVIPRP VRKNNNPQQT NQNEEEEMSE EEEEEESDD
//
