ID M2S193_ENTHI Unreviewed; 675 AA.
AC M2S193;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=EHI5A_008730 {ECO:0000313|EMBL:EMD44587.1};
OS Entamoeba histolytica KU27.
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=885311 {ECO:0000313|EMBL:EMD44587.1};
RN [1] {ECO:0000313|EMBL:EMD44587.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KU27 {ECO:0000313|EMBL:EMD44587.1};
RA Hannick L., Zafar N., Lorenzi H., Ali I.A., Petri W.P., Caler E.;
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; KB445006; EMD44587.1; -; Genomic_DNA.
DR AlphaFoldDB; M2S193; -.
DR EnsemblProtists; EMD44587; EMD44587; EHI5A_008730.
DR VEuPathDB; AmoebaDB:EHI5A_008730; -.
DR Proteomes; UP000011755; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF109; ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:EMD44587.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 50..213
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 234..403
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 675 AA; 77123 MW; 585852D1D46AA802 CRC64;
MKRDIKHSKK RIDLEEIINP LNGKPYSENY FKLQEKINAL PVKQYEKEVI NELKKNRVLI
LEGATGSGKT TQIPKFCLNP EICGGKGVCC TQPRRVAAIS VAQRVAEEMD VQLGEEVGYC
VRFDDCRSDK TKLTYMTDGM LLRELMGDPK IQKYGVILLD EAHERTVSTD ILFGVLKSLL
EEREDLKIVV MSATLEATKF KEYFDNAPNM SVEGRTYPVT INYSRYPEND YFEAAVKVVS
KIDNEPEGDV LIFMTGEEEI EEMVARINSM KTKSHMIALP LYSALPQQEQ QRVFEKVNGR
KVIVSTNIAE TSVTIDGIVY VIDTGYVKQK VYLPSTRVET LQVTAISQAA AQQRAGRAGR
TRPGQCYRLY TEKGFNESLP KQTVPEMLRT SLASVILHMK KIGIKDILHF DYLDAPSPQV
MVRALEQLYY LNALDDKTNL TEIGSKISEI PVDPQLAVTL IASIDYNVVD EISTIVSLLN
VPSIFYRPKE QEEKSKADAA KAYFNDHESD HITLLNTYNA WIENGKDSKW AWNNYVNQRA
LKQAESIKNQ LLGILYRMGV KQQQKPIEDV RKRKELIRKA LCKGFFMQSA HQVKGGYQIV
CDNRIVLLHP SSCIGKREWI LYNEYVMTKR EYVRTASSIQ PEWLFEASPK YFAQLDKFKE
SETTRALKRV KRAMN
//
