ID   M2S644_ENTHI            Unreviewed;       519 AA.
AC   M2S644;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
GN   ORFNames=EHI5A_083080 {ECO:0000313|EMBL:EMD46801.1};
OS   Entamoeba histolytica KU27.
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=885311 {ECO:0000313|EMBL:EMD46801.1, ECO:0000313|Proteomes:UP000011755};
RN   [1] {ECO:0000313|EMBL:EMD46801.1, ECO:0000313|Proteomes:UP000011755}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KU27 {ECO:0000313|EMBL:EMD46801.1,
RC   ECO:0000313|Proteomes:UP000011755};
RA   Hannick L., Zafar N., Lorenzi H., Ali I.A., Petri W.P., Caler E.;
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KB444459; EMD46801.1; -; Genomic_DNA.
DR   AlphaFoldDB; M2S644; -.
DR   EnsemblProtists; EMD46801; EMD46801; EHI5A_083080.
DR   VEuPathDB; AmoebaDB:EHI5A_083080; -.
DR   Proteomes; UP000011755; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR   PANTHER; PTHR12673:SF159; RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR JJ; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
FT   DOMAIN          187..365
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   519 AA;  60422 MW;  0AFAC5B321756FAB CRC64;
     MKQLSKTSEN PLQTLHRSIT SEELKKRRRA ERFDCPSCIE MQGYISVLEE IIQKKNTIIA
     KLMNEKEVYK IFDELRQAND PSVYAEDTIE TLISFIENRN IETKNNVMKK WEVMLQSRIS
     NENKKVLKSF VRNKVKTKYQ YIDIGDETTT ESDVQDDSTI LEPLDGMDYN RCDQPKPKIN
     EKLFGCLVDD FTSSQILYYQ QFQILTQLFI SPLRNLQMAK ESIKLLDNLI PPMMMVERKV
     SRCLQLKDET MWQTIKECIS EMKVYIPYIS TLKTTTIKAD IVECCMSKEF KKEQQPLIAN
     FFNKNGSQQL LPVTVYLEAP VQRFFKYPKI FGNLLASVDP KRHDYAIITS CYLNINKMVK
     KMGDYQTNQE EQKKVIELSH LFKQTQTQIL KDGRKLLYYG PLKIIEEKNE WNMCFLFNDL
     FVVSKAIVIG ALGLEKESLM RFENAPSGTD LSSLMPYNFN EILCVSLSHF LLKKVVDCNT
     ATNAFMIQVN DIQLHCCCVS VKERHNWIGS LLLTQNGSY
//