ID M2U5T2_COCH5 Unreviewed; 1113 AA.
AC M2U5T2;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=alpha-mannosidase {ECO:0000256|ARBA:ARBA00012752};
DE EC=3.2.1.24 {ECO:0000256|ARBA:ARBA00012752};
GN ORFNames=COCHEDRAFT_1192060 {ECO:0000313|EMBL:EMD93894.1};
OS Cochliobolus heterostrophus (strain C5 / ATCC 48332 / race O) (Southern
OS corn leaf blight fungus) (Bipolaris maydis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Bipolaris.
OX NCBI_TaxID=701091 {ECO:0000313|EMBL:EMD93894.1, ECO:0000313|Proteomes:UP000016936};
RN [1] {ECO:0000313|EMBL:EMD93894.1, ECO:0000313|Proteomes:UP000016936}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C5 / ATCC 48332 / race O {ECO:0000313|Proteomes:UP000016936};
RX PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA Grigoriev I.V.;
RT "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT genomes of eighteen Dothideomycetes fungi.";
RL PLoS Pathog. 8:E1003037-E1003037(2012).
RN [2] {ECO:0000313|Proteomes:UP000016936}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C5 / ATCC 48332 / race O {ECO:0000313|Proteomes:UP000016936};
RX PubMed=23357949; DOI=10.1371/journal.pgen.1003233;
RA Condon B.J., Leng Y., Wu D., Bushley K.E., Ohm R.A., Otillar R., Martin J.,
RA Schackwitz W., Grimwood J., MohdZainudin N., Xue C., Wang R., Manning V.A.,
RA Dhillon B., Tu Z.J., Steffenson B.J., Salamov A., Sun H., Lowry S.,
RA LaButti K., Han J., Copeland A., Lindquist E., Barry K., Schmutz J.,
RA Baker S.E., Ciuffetti L.M., Grigoriev I.V., Zhong S., Turgeon B.G.;
RT "Comparative genome structure, secondary metabolite, and effector coding
RT capacity across Cochliobolus pathogens.";
RL PLoS Genet. 9:E1003233-E1003233(2013).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792}.
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DR EMBL; KB445572; EMD93894.1; -; Genomic_DNA.
DR AlphaFoldDB; M2U5T2; -.
DR STRING; 701091.M2U5T2; -.
DR eggNOG; KOG4342; Eukaryota.
DR HOGENOM; CLU_003442_0_1_1; -.
DR OMA; GQYWDAW; -.
DR Proteomes; UP000016936; Unassembled WGS sequence.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR CDD; cd10812; GH38N_AMII_ScAms1_like; 1.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR041147; GH38_C.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF17677; Glyco_hydro38C2; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000313|EMBL:EMD93894.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000016936}.
FT DOMAIN 552..636
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
SQ SEQUENCE 1113 AA; 126499 MW; 311BF3DF19EDEC5B CRC64;
MELMQANDYP KLSDGPVGKQ IHSIYESRLR QFFDGGQYRE QSLIGKLTEA VASGPEWIKL
SVYSPPDLSR PLFDEATSHA FHPTKVGESF GPSWSTHWFK VQLTLPDYLL DKEHLEFVWD
ANNEGLIWTE DGRTVHGLTG GGERTQWILP KAFRDGKEHT FYIEMACNGM FGNAPGGDSI
QPPNPDRYYT LHTAEVQAVN LDARGLYFDF WEISDAAREF PSDSTQIHDA QQVCNRIMDT
FIAGNGSRES IKAARKIAAE YVGNNVDSHK VYQGDQEAIV HGIGYCHIDT CWLWPFDETK
RKVNRSWSNQ CDLIDRYPEL RFCCSQAQQY KWLEQYYPST FDRVKKKVKE GSFQPIGGSW
VEHDTNLPGG ESLIRQFLYG QRYFESKFGQ RCRTFWLPDT FGYSSQLPQI CRISGMTRFL
TQKLSWNNIN NFPHTTFNWV SLDNSQVICH MPPCETYTCE ANFGDVKRSV TQHKSLDQDK
TSLLVFGKGD GGGGPTWQHL EKLRRCRGIS DTAGLLPRVK LGDSADDFFD RLEKKVANGD
ELVTWYGELY FELHRGTYTT QANNKRNNRK SEIMLRDIEY LATLATIKNG FGKKSTYKYP
KKEIDDMWEN VLLCQFHDCL PGSSIEMCYD DSDRIYASVF ATGEKLLSDA LAELGFSDHI
TWNENTKLMA INTLPWNRCE VIKLPAGARQ SVYGQEETRY GLAYSNGSNK GFGALEIAPM
ASRIPESKAF IEEIRPNVYQ MRNSQFEVEV TDGAITSLFD IQAKRELIPK GAKAGQLVIF
DDKPLYWQAW DVEVYHLKSR QELKPSKVTI TENSMHRVSL EVETKISDKS WIKTTMSLPA
AGTTPSAIEF DAEIEWHETM KFLKVEFPVD IVNTEASYET QFGIVRRPTH YNTSWDMAKF
EVCCHKWADL SEATYGVSIL NDNKYGFATA GNVMRLSLLR APKAPDAHAD MGNHKTRYAI
FPHEGPLDHR TIRKAFEFNN PLKIVGTSST QDKHDASLLN PFHIYNAPNL VLDTIKRGED
DEDVSRGELP VKKGHSVILR IYDALGGKSK GVLTWGNLNV TKVTKVNALE DEEENTEVLR
ICSLRTGDAE AMETGVEVEV RAFEVATYKL LLG
//
