ID M2WLE1_DOTSN Unreviewed; 1174 AA.
AC M2WLE1;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN ORFNames=DOTSEDRAFT_24854 {ECO:0000313|EMBL:EME42838.1};
OS Dothistroma septosporum (strain NZE10 / CBS 128990) (Red band needle blight
OS fungus) (Mycosphaerella pini).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Dothistroma.
OX NCBI_TaxID=675120 {ECO:0000313|EMBL:EME42838.1, ECO:0000313|Proteomes:UP000016933};
RN [1] {ECO:0000313|Proteomes:UP000016933}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NZE10 / CBS 128990 {ECO:0000313|Proteomes:UP000016933};
RX PubMed=23209441; DOI=10.1371/journal.pgen.1003088;
RA de Wit P.J.G.M., van der Burgt A., Oekmen B., Stergiopoulos I.,
RA Abd-Elsalam K.A., Aerts A.L., Bahkali A.H., Beenen H.G., Chettri P.,
RA Cox M.P., Datema E., de Vries R.P., Dhillon B., Ganley A.R.,
RA Griffiths S.A., Guo Y., Hamelin R.C., Henrissat B., Kabir M.S.,
RA Jashni M.K., Kema G., Klaubauf S., Lapidus A., Levasseur A., Lindquist E.,
RA Mehrabi R., Ohm R.A., Owen T.J., Salamov A., Schwelm A., Schijlen E.,
RA Sun H., van den Burg H.A., van Ham R.C.H.J., Zhang S., Goodwin S.B.,
RA Grigoriev I.V., Collemare J., Bradshaw R.E.;
RT "The genomes of the fungal plant pathogens Cladosporium fulvum and
RT Dothistroma septosporum reveal adaptation to different hosts and lifestyles
RT but also signatures of common ancestry.";
RL PLoS Genet. 8:E1003088-E1003088(2012).
RN [2] {ECO:0000313|EMBL:EME42838.1, ECO:0000313|Proteomes:UP000016933}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NZE10 / CBS 128990 {ECO:0000313|Proteomes:UP000016933};
RX PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA Grigoriev I.V.;
RT "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT genomes of eighteen Dothideomycetes fungi.";
RL PLoS Pathog. 8:E1003037-E1003037(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- SIMILARITY: Belongs to the peptidase C19 family.
CC {ECO:0000256|ARBA:ARBA00009085}.
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DR EMBL; KB446540; EME42838.1; -; Genomic_DNA.
DR AlphaFoldDB; M2WLE1; -.
DR STRING; 675120.M2WLE1; -.
DR EnsemblFungi; EME42838; EME42838; DOTSEDRAFT_24854.
DR eggNOG; KOG1863; Eukaryota.
DR HOGENOM; CLU_003532_2_1_1; -.
DR OMA; HTAHHRF; -.
DR OrthoDB; 51419at2759; -.
DR Proteomes; UP000016933; Unassembled WGS sequence.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02659; peptidase_C19C; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR024729; USP7_ICP0-binding_dom.
DR InterPro; IPR029346; USP_C.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF644; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7; 1.
DR Pfam; PF00443; UCH; 1.
DR Pfam; PF14533; USP7_C2; 1.
DR Pfam; PF12436; USP7_ICP0_bdg; 1.
DR SMART; SM00061; MATH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 1.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000016933};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 69..200
FT /note="MATH"
FT /evidence="ECO:0000259|PROSITE:PS50144"
FT DOMAIN 226..551
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1174 AA; 134848 MW; E91E305B072250D7 CRC64;
MLLDSDYDEK RLTPNDENDN VAIISPDDAD SMVDDPEPGA EPALPSADDH EAMMARFMPA
SPDYETEAEI VHTWDITNWR TLPKRTHGPV FQCAGHPWRI LFFPAGNSAS ESVSFYLEQG
FGDEKPPQDW YACAQFMLVL HNPKDPSIYI HHEANHRFTA EEGDWGFTRF VDKNRIFAAK
FDNADRPLVE DDGARMTAYV RVLKDPTGVL WHNFINYDSK KETGMVGLRN QGATCYLNSL
LQSLYLTGAF RKAVYQIPTE TPEDKEASQS AYMLQRLFYR LQADPAAVGT QELTHSFGWE
SRQIFEQQDV QELSRILMEK LETRMKGTEA ENALNNMFVG KMKTYLKCVN VEYESSRIEE
FWDLQLNVSG CKSLDDSFRD YIQKELLEGD NKYAAEGYGL QDAEKGVIFE SFPNVLHLQL
KRFEYDFQRD AMMKVNDRYE FPEIFDATPY LDETADKSEP YVYHLHGVLV HSGDLNAGHY
YAFLKPEKNG QFYRFDDDRV TRATKREAID ENFGGDYGAN GTYGQKGQNP YTRQWSTKRS
NNAYMLVYIR ESRLDQIILP DTDVKPPAHL PAKIAEEREL AERRRKEKEE AHLYMNVLVA
TEANFKAYQG VDLIPWTSEQ SDDPAVPKVH RLLRDMTIQD FTTFLAQQQG LDKDLVRPWI
MVNRQNGTVR PDHPLSWPDM TLQEAADKFS TRQSGFRVFV EETTRDDKGL PVWPDDDEVV
QPATPLVNGN ATQQQKPIIL FLKYFDVDRQ LLIGVGHVYM NPLDKAQDLA TPILEIMKWE
AGSIHLELFE EIKQNYIEPM KPRNTLIASE IQDGDIICFQ RHLEDPESAT IKTRSPGACL
TAPAYYDFMM NRLFVDFTPK TLPAQNLQVK DGDERFKLAL SKKDSYDAIA HKVAEHLSKV
NPTPVDPTHL RFTTTNIQSG KPRAIVKRVQ GATVSTILLG TSGYGGYSYA PSQAPDHLFY
EVLEMSLTDL EQRKNVRVTW LSEGITKEEQ VDLLVHKQSQ FDAVLEALHK KLQLPDEILD
HIRFYEAHSN KVYKIIPNSH GVLALNEFMS VYAERIPEEE KQLDADKGDR LLNCFHFEKD
PSKSHGVPFI CLMKDGEVFK ETKERISKRT GIKGKNLEKV RFAVIKGGQN YSRPQWVEDD
DILSEKLSPD DHLGLEHPNR NRNNWARYES LNIR
//
