ID   M2XUV9_GALSU            Unreviewed;       760 AA.
AC   M2XUV9;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   SubName: Full=Ubiquitin-protein ligase (Cullin) {ECO:0000313|EMBL:EME27423.1};
GN   ORFNames=Gasu_50180 {ECO:0000313|EMBL:EME27423.1};
OS   Galdieria sulphuraria (Red alga).
OC   Eukaryota; Rhodophyta; Bangiophyceae; Galdieriales; Galdieriaceae;
OC   Galdieria.
OX   NCBI_TaxID=130081 {ECO:0000313|EMBL:EME27423.1, ECO:0000313|Proteomes:UP000030680};
RN   [1] {ECO:0000313|Proteomes:UP000030680}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=074W {ECO:0000313|Proteomes:UP000030680};
RX   PubMed=23471408; DOI=10.1126/science.1231707;
RA   Schonknecht G., Chen W.H., Ternes C.M., Barbier G.G., Shrestha R.P.,
RA   Stanke M., Brautigam A., Baker B.J., Banfield J.F., Garavito R.M., Carr K.,
RA   Wilkerson C., Rensing S.A., Gagneul D., Dickenson N.E., Oesterhelt C.,
RA   Lercher M.J., Weber A.P.;
RT   "Gene transfer from bacteria and archaea facilitated evolution of an
RT   extremophilic eukaryote.";
RL   Science 339:1207-1210(2013).
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast
CC       {ECO:0000256|ARBA:ARBA00004229}.
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
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DR   EMBL; KB454532; EME27423.1; -; Genomic_DNA.
DR   RefSeq; XP_005703943.1; XM_005703886.1.
DR   AlphaFoldDB; M2XUV9; -.
DR   STRING; 130081.M2XUV9; -.
DR   EnsemblPlants; EME27423; EME27423; Gasu_50180.
DR   GeneID; 17086333; -.
DR   Gramene; EME27423; EME27423; Gasu_50180.
DR   KEGG; gsl:Gasu_50180; -.
DR   eggNOG; KOG2166; Eukaryota.
DR   OMA; MFKDMTI; -.
DR   OrthoDB; 21270at2759; -.
DR   Proteomes; UP000030680; Unassembled WGS sequence.
DR   GO; GO:0009507; C:chloroplast; IEA:UniProtKB-SubCell.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF168; CULLIN-3; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Ligase {ECO:0000313|EMBL:EME27423.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030680}.
FT   DOMAIN          399..631
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
SQ   SEQUENCE   760 AA;  89436 MW;  B6F12F2B7B2DB828 CRC64;
     MSRRLGSRVL ILPFKHSVQA DPKYAERTWD SLKEAIKEIC KHNTGVLSYE ELYRNAYNLV
     LHKHGDMLYN GLEECLTELL DQVVKQVAAH AESSFLERVK QEWEWHKVSM VHIRDILMYM
     DRTYVAAKRK TPVYDLGMAL FREVFIKSPL IYERLVNGIL GHIQLERKGE EVNRQLMASL
     IIMLRDLNGE QEGEEIFCDF ERRLLKETAD FYYGEAQLQL SICSCPVYLK RVEQRLVEEQ
     DRIQNYLVIN SPSELIKVVQ DELVTRHMET ILDMENSGFI HLVRNDCIQD LATMYNLFHQ
     VQGGDELLRS RLKKEIRTQG NIILNDVDNR NDPIRWVEAV IRLRQKYMNI VCHAFGSRQA
     ACTTWSSQVD TWSLETCVDK KLLQTVNDSF EWFLNQFIRT SEYLSLYLDH RIRTDFRNAS
     EAELESCFEQ VILLFRAVRE KDLFERYYKQ HLAKRLLSGR NFSEDIERIF IEKLKSECGY
     QFTSKLEVMF TDIRTSAEEV EAFRSAMEDL QLSLNGIEFQ VNVLTTGCWP IRNQPSARLP
     LEMQRCCQVS GAFEKVYFAR HSGRLLSWQT SLGNVELRAY FPSRRHELMV STHQAIILLL
     FNHNDELSFR QIQEETGLPQ SELIRCLKSL ACGKYRILCK EPKGKEVLDT DMFSFHSKFT
     CKLVRIKVSN IMAEKETEEE KRETQGRVDD DRKPQIEAAI VRIMKARRYL DHNNLVSEVI
     SQLQTHFVPE PAEIKRRIES LIEREFLERD NNQRSYRYVA
//