ID M3AZI1_PSEFD Unreviewed; 1016 AA.
AC M3AZI1;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EME82612.1};
GN ORFNames=MYCFIDRAFT_163981 {ECO:0000313|EMBL:EME82612.1};
OS Pseudocercospora fijiensis (strain CIRAD86) (Black leaf streak disease
OS fungus) (Mycosphaerella fijiensis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Pseudocercospora.
OX NCBI_TaxID=383855 {ECO:0000313|EMBL:EME82612.1, ECO:0000313|Proteomes:UP000016932};
RN [1] {ECO:0000313|EMBL:EME82612.1, ECO:0000313|Proteomes:UP000016932}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CIRAD86 {ECO:0000313|EMBL:EME82612.1,
RC ECO:0000313|Proteomes:UP000016932};
RX PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA Grigoriev I.V.;
RT "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT genomes of eighteen Dothideomycetes fungi.";
RL PLoS Pathog. 8:E1003037-E1003037(2012).
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the
CC formate--tetrahydrofolate ligase family.
CC {ECO:0000256|ARBA:ARBA00006985}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the tetrahydrofolate
CC dehydrogenase/cyclohydrolase family. {ECO:0000256|ARBA:ARBA00005559}.
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DR EMBL; KB446558; EME82612.1; -; Genomic_DNA.
DR RefSeq; XP_007926092.1; XM_007927901.1.
DR AlphaFoldDB; M3AZI1; -.
DR STRING; 383855.M3AZI1; -.
DR GeneID; 19332152; -.
DR KEGG; pfj:MYCFIDRAFT_163981; -.
DR eggNOG; KOG4230; Eukaryota.
DR HOGENOM; CLU_003601_2_1_1; -.
DR OrthoDB; 651667at2759; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000016932; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; IEA:UniProtKB-EC.
DR GO; GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR CDD; cd00477; FTHFS; 1.
DR CDD; cd01080; NAD_bind_m-THF_DH_Cyclohyd; 1.
DR Gene3D; 3.10.410.10; Formyltetrahydrofolate synthetase, domain 3; 1.
DR Gene3D; 3.40.50.10860; Leucine Dehydrogenase, chain A, domain 1; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_01543; FTHFS; 1.
DR HAMAP; MF_01576; THF_DHG_CYH; 1.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR000559; Formate_THF_ligase.
DR InterPro; IPR020628; Formate_THF_ligase_CS.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000672; THF_DH/CycHdrlase.
DR InterPro; IPR020630; THF_DH/CycHdrlase_cat_dom.
DR InterPro; IPR020867; THF_DH/CycHdrlase_CS.
DR InterPro; IPR020631; THF_DH/CycHdrlase_NAD-bd_dom.
DR PANTHER; PTHR48099:SF5; C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC; 1.
DR PANTHER; PTHR48099; C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED; 1.
DR Pfam; PF01268; FTHFS; 1.
DR Pfam; PF00763; THF_DHG_CYH; 1.
DR Pfam; PF02882; THF_DHG_CYH_C; 1.
DR PRINTS; PR00085; THFDHDRGNASE.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00721; FTHFS_1; 1.
DR PROSITE; PS00722; FTHFS_2; 1.
DR PROSITE; PS00767; THF_DHG_CYH_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000016932}.
FT DOMAIN 78..194
FT /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00763"
FT DOMAIN 199..361
FT /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF02882"
SQ SEQUENCE 1016 AA; 108988 MW; 86AE1A469830C3C3 CRC64;
MIPRMIGASR LLPHRHRCLD CKFRLLPPPI SPSALAFPSV RPHLPSPARL ASLTRPPYKA
AGLRSFSSTA AKMTAAKIDG TAIAKSLRQR ISKEVTEKQA KNLRYKPSLV IIQVGDRQDS
STYVRMKLKA CEEANIACEL VKYDESISRY ELLEKIEQYN NDSSVHGMLV QLPLPKHINE
YEITSAVADQ KDVDGFGAVN IGELAKKGGR PMFVPCTPKG VMALLKESGI EVRGKNAIVI
GRSDIVGAPV SYLLRNADAT VTVCHSKTAN LKDVVKTGDI VVAALGSPGF VKGDWLKPGA
VVIDVGTNPI PDETKKSGQR LVGDVDYESA VEVASQITPV PGGVGPMTVA MLLSNVVDAA
DAYFAQQKSR HITPLPLKLK QPVPSDIEVS RSQHPKLINK VAAEVGIAPY ELEPYGAYKA
KVSLDVLKRL EHRKNGRYIL VAGITPTPLG EGKSTTTIGL TQALAGQLGR IAFANVRQPS
QGPTFGIKGG AAGGGYSQVI PMDEFNLHLT GDIHAITAAN NLLAAAIDTR MFHEATQKDA
ALYSRLVPKK KGGREFAKVM FKRLKKLGID KTNPDDLTPE EITKFARLDI DPETITWRRV
LDVNDRHLRG ITIGQAPTES KVEPRQTGFD ISVASECMAV LALSTDLADM RDRLGRMVVA
SSKAGDPVTA DDIGVGGALA VLMKDAVKPN MMQTLEGTPV FVHAGPFANI SIGNSSIIAD
RVALKLAGTE PDEDADRNGK VGFVVTEAGF DFTMGGERFM NIKCRASGLV PDVVVIVATV
RALKVHGGGP EIKPGAQLDE VYRTENVDIL RAGCVNLAKH IANAKAYGVN VVVAINKFET
DTDAEHQVIR EEAIKAGAED AIVANHWAEG GKGAVDLAQG IIKAAEKAKP EDFHLLYNTD
GDIQTRIETI AKDMYGASKV SFSELAQKKL DTYTKQGYGN LPICIAKTQY SISHDPALKG
APTGFEVPVR DVRMAAGAGY LYALAADIQT IPGLPTAPGY LNVDLDGETG EIDGLF
//