ID M3IM30_CANMX Unreviewed; 877 AA.
AC M3IM30;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE RecName: Full=DNA mismatch repair proteins mutS family domain-containing protein {ECO:0000259|PROSITE:PS00486};
GN ORFNames=G210_2236 {ECO:0000313|EMBL:EMG47441.1};
OS Candida maltosa (strain Xu316) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=1245528 {ECO:0000313|EMBL:EMG47441.1, ECO:0000313|Proteomes:UP000011777};
RN [1] {ECO:0000313|EMBL:EMG47441.1, ECO:0000313|Proteomes:UP000011777}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Xu316 {ECO:0000313|Proteomes:UP000011777};
RA Yu J., Wang Q., Geng X., Bao W., He P., Cai J.;
RT "Genome sequence of Candida maltosa Xu316, a potential industrial strain
RT for xylitol and ethanol production.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|RuleBase:RU003756}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMG47441.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AOGT01001573; EMG47441.1; -; Genomic_DNA.
DR AlphaFoldDB; M3IM30; -.
DR STRING; 1245528.M3IM30; -.
DR eggNOG; KOG0219; Eukaryota.
DR HOGENOM; CLU_002472_10_0_1; -.
DR OMA; LVRFPQK; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000011777; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF35; DNA MISMATCH REPAIR PROTEIN MSH2; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000011777}.
FT DOMAIN 710..726
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
SQ SEQUENCE 877 AA; 98717 MW; 98D871E470D424A7 CRC64;
MSSTRPELKF NGSSDERQYF KKYSQLPEKE STTVRFISHN NHDYFTVLKE DADLIAENVY
RSRASIKISN GTQYLSLSLQ NFKESLKFCL KNHYKVEIYD SKTFELLNSG SVGNLESLSE
EFEIEFDFSD GSNSCIAAIK LGKKIGVCVI EDTEIYFSEF EDNDVFSNLE SLLIQLGVNE
VLISAKVENN KFLQALEKIN NLVVSAVNSF PKDVDQDLSK LLDTENIELT LASKGLNSTD
YSLSLSCCGA LIQYLDLLNS SKTFTLNKYN LSTYMKLDSS TMKALNIFPS GNNKGVTSIY
ELFKCKTAAG SRLLSQWLKQ PLIDQGTITE RQKLVESMID DTSLRVETQD FLSGVPDITR
LLKKISTGMK KSGGENKKLN DVVHLYDTVT SLPKLMDVLN IDYYTTPLEK NQEALARFCE
LVETTITLDI DAYEDHKIKP EFDASLVEID GRMKSALESI NQLHADAGDD LNMEINKKLK
LEQHQVHGWC LRLTRIESVV LRNNKKYQEL QTQKSGVIFT TKELKNLSKE YGKACEEYNI
KQREVIREVL SLTLTYESVF NSLASTLAHL DVITSFAIAS ILNSYTKPTL YPFNESARKI
NLIESRHPLL EVQDDINFIS NDVTMDENRF VIITGPNMGG KSTYIRQIGV ISLLAQIGSF
IPANEGAELP IFDAILSRVG AGDSQLKGLS TFMIEMLETS SILATATENS LIIIDELGRG
TSTYDGFGLA WSISEHLITD KKCFSMFATH FHELNKLSEK YSGKVQNLHV VAQENEENDI
TLMYKVEPGI SDKSFGIHVA ELVKFPQKII NMAKRKAEEL SEEPPLKKQC SPQEVSEGMT
RLKEILKSWR ANPDTKVLQS TLAGESNKFI LEIVNNL
//
