ID   M3LV05_HELPX            Unreviewed;       241 AA.
AC   M3LV05;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=ThiF family protein {ECO:0000313|EMBL:EMG92027.1};
GN   ORFNames=HMPREF1399_01313 {ECO:0000313|EMBL:EMG92027.1};
OS   Helicobacter pylori GAM118Bi.
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=1159027 {ECO:0000313|EMBL:EMG92027.1, ECO:0000313|Proteomes:UP000011879};
RN   [1] {ECO:0000313|EMBL:EMG92027.1, ECO:0000313|Proteomes:UP000011879}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GAM118Bi {ECO:0000313|EMBL:EMG92027.1,
RC   ECO:0000313|Proteomes:UP000011879};
RA   Weinstock G., Sodergren E., Lobos E.A., Fulton L., Fulton R., Courtney L.,
RA   Fronick C., O'Laughlin M., Godfrey J., Wilson R.M., Miner T., Farmer C.,
RA   Delehaunty K., Cordes M., Minx P., Tomlinson C., Chen J., Wollam A.,
RA   Pepin K.H., Bhonagiri V., Zhang X., Suruliraj S., Antonio M., Secka O.,
RA   Thomas J., Warren W., Mitreva M., Mardis E.R., Wilson R.K.;
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EMG92027.1}.
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DR   EMBL; APDD01000072; EMG92027.1; -; Genomic_DNA.
DR   AlphaFoldDB; M3LV05; -.
DR   PATRIC; fig|1159027.3.peg.1250; -.
DR   HOGENOM; CLU_013325_10_0_7; -.
DR   Proteomes; UP000011879; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR   CDD; cd00757; ThiF_MoeB_HesA_family; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR045886; ThiF/MoeB/HesA.
DR   InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR   InterPro; IPR035985; Ubiquitin-activating_enz.
DR   PANTHER; PTHR10953:SF102; ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3; 1.
DR   PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR   Pfam; PF00899; ThiF; 1.
DR   SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          2..227
FT                   /note="THIF-type NAD/FAD binding fold"
FT                   /evidence="ECO:0000259|Pfam:PF00899"
SQ   SEQUENCE   241 AA;  26285 MW;  D473B94BC04EA876 CRC64;
     MLEDVGEEGQ LKLLKSSVLV IGAGGLGSAV LMYLCAAGIG KIGIVDFDVV GMSNLQRQII
     HSQDFLNHSK TSSAKARLKQ LNAGIEVETF EERFKAHNAL SLIEPYDFII DATDNFNAKF
     LINDACVLAQ KPYSHAGVLK YRGQSMSVLP NSACLACVFD KPPKKGFNPT SGLFGVLPGV
     LGCIQASECL KYFLGFETLL INTLLIADIK TMDFKKIQAP KNPECRVCGT HKITHLQDYE
     I
//