ID M3VVE2_FELCA Unreviewed; 2853 AA.
AC M3VVE2;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=APC regulator of WNT signaling pathway {ECO:0000313|Ensembl:ENSFCAP00000000728.5};
GN Name=APC {ECO:0000313|Ensembl:ENSFCAP00000000728.5,
GN ECO:0000313|VGNC:VGNC:99681};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000000728.5, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000000728.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000728.5,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000000728.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000728.5,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000000728.5}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000728.5};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the adenomatous polyposis coli (APC) family.
CC {ECO:0000256|ARBA:ARBA00009051}.
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DR EMBL; AANG04001174; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSFCAT00000000787.6; ENSFCAP00000000728.5; ENSFCAG00000000787.6.
DR VGNC; VGNC:99681; APC.
DR eggNOG; KOG2122; Eukaryota.
DR GeneTree; ENSGT00530000063749; -.
DR HOGENOM; CLU_001012_0_0_1; -.
DR Proteomes; UP000011712; Chromosome A1.
DR Bgee; ENSFCAG00000000787; Expressed in brain and 10 other cell types or tissues.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0008013; F:beta-catenin binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.450; Helix hairpin bin; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR009240; APC_15aa_rpt.
DR InterPro; IPR009234; APC_basic_dom.
DR InterPro; IPR026831; APC_dom.
DR InterPro; IPR026818; Apc_fam.
DR InterPro; IPR041257; APC_rep.
DR InterPro; IPR009223; APC_rpt.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR009232; EB1-bd.
DR InterPro; IPR009224; SAMP.
DR PANTHER; PTHR12607:SF11; ADENOMATOUS POLYPOSIS COLI PROTEIN; 1.
DR PANTHER; PTHR12607; ADENOMATOUS POLYPOSIS COLI PROTEIN FAMILY; 1.
DR Pfam; PF05972; APC_15aa; 4.
DR Pfam; PF05956; APC_basic; 1.
DR Pfam; PF05923; APC_r; 7.
DR Pfam; PF18797; APC_rep; 1.
DR Pfam; PF16634; APC_u13; 1.
DR Pfam; PF16635; APC_u14; 1.
DR Pfam; PF16636; APC_u15; 1.
DR Pfam; PF16630; APC_u5; 1.
DR Pfam; PF16633; APC_u9; 1.
DR Pfam; PF00514; Arm; 3.
DR Pfam; PF16629; Arm_APC_u3; 1.
DR Pfam; PF05937; EB1_binding; 1.
DR Pfam; PF05924; SAMP; 3.
DR Pfam; PF11414; Suppressor_APC; 1.
DR SMART; SM00185; ARM; 7.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF82931; Tumor suppressor gene product Apc; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT REPEAT 668..710
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT DOMAIN 2234..2585
FT /note="Adenomatous polyposis coli protein basic"
FT /evidence="ECO:0000259|Pfam:PF05956"
FT DOMAIN 2680..2853
FT /note="EB-1 binding"
FT /evidence="ECO:0000259|Pfam:PF05937"
FT REGION 229..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 783..886
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 904..941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 965..995
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1066..1092
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1107..1175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1200..1258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1316..1384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1411..1484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1529..1621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1672..1728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1758..1857
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1887..1953
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1976..2021
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2055..2077
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2158..2194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2244..2646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2675..2724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2742..2853
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 124..158
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 234..252
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..820
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 821..849
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 850..865
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 966..983
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1074..1088
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1109..1138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1140..1175
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1316..1353
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1365..1382
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1441..1456
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1553..1571
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1689..1709
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1758..1772
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1796..1841
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1887..1904
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1905..1947
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1988..2005
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2180..2194
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2244..2259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2268..2436
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2471..2517
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2529..2543
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2567..2590
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2591..2606
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2627..2646
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2679..2696
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2707..2721
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2747..2823
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2833..2853
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2853 AA; 313133 MW; 73195458671CEA78 CRC64;
MQKKLVENEF PGFFEENLSR EELRWERNCF KSQEAEVLKQ LQGSIEDEAM ASSGQIDLLE
RLKELNLDSS NFPGVKLRSK MSLRSYGSRE GSVSSRSGEC SPVPMGSFPK RGFVNGSREN
TGYLEELEKE RSLLLADLDK EEKEKDWYYA QLQNLTKRID SLPLTENFSL QTDMTRRQLE
YEARQIRVAM EEQLGTCQDM EKRAQRRVTR IQQIEKDILR IRQLLQSQAT EAERSSQSKH
EAGSHEAERQ NEGQGVAEIN MATPGSGQGS AARMDHETAS VLSSSSTHSA PRRLTSHLGT
KVEMVYSLLS MLGTHDKDDM SRTLLAMSSS QDSCISMRQS GCLPLLIQLL HGNDKDSVLL
GNSRGSKEAR ARASAALHNI IHSQPDDKRG RREIRVLHLL EQIRAYCETC WEWQEAHEQG
MDQDKNPMPA PVEHQICPAV CVLMKLSFDE EHRHAMNELG RKATRGISSQ ELGQGLAGGL
QAIAELLQVD CEMYGLTNDH YSITLRRYAG MALTNLTFGD VANKATLCSM KGCMRALVAQ
LKSESEDLQQ VIASVLRNLS WRADVNSKKT LREVGSVKAL MECALEVKKE STLKSVLSAL
WNLSAHCTEN KADICAVDGA LAFLVGTLTY RSQTNTLAII ESGGGILRNV SSLIATNEDH
RQILRENNCL QTLLQHLKSH SLTIVSNACG TLWNLSARNP KDQEALWDMG AVSMLKNLIH
SKHKMIAMGS AAALRNLMAN RPAKYKDANI MSPGSSLPSL HVRKQKALEA ELDAQHLSET
FDNIDNLSPK ASHRSKQRHK PNLYGDYVFD TNRHDDNRSD NFNTGNMTVL SPYLNTTVLP
SSSSSRGSLD SSRSEKDRSL ERERGISLGN YHPATENPGT SSKRGLQIST TAAQIAKVME
EVSAIHTSQE DRSSGSTGEL HCGTDERNAL RRSSTAHTHA NTYNFTKSEN SNRTCPMPYA
KLEYKRSSND SLNSVSSSDG YGKRGQMKPS IESYSEDDES KFCSYGQYPA DLAHKIHSAN
HMDDNDGELD TPINYSLKYS DEQLNSGRQS PSQNERWARP KHIIEDEIKQ SEQRQSRSQS
TTYPVYTEST DDKHLKFQPH FGQQECVSPY RSRGANGSET NRVSSNHGIN QNVNQSLCQE
DDYEDDKPTN YSERYSEEEQ HEEEERPTNY SIKYNEEKHH VDQPIDYSLK YATDIPASQK
PPFSFSKSSS GQSTKTEHIS SSSENTSTPS SNAKRQNQHH PSSTQSRNGQ TPKATSCKVP
SINQETIQTY CVEDTPICFS RCSSLSSLSS AEDEIGCDQT TQETDSANTL QIAEIKENSG
TRSTEESVSE VPTVSQHIRT KSSRLQASGL SAESTRHKAV EFSSGAKSPS KSGAQTPKSP
PEHYVQETPL MFSRCTSVSS LDSFESRSIA SSVQSEPCSG MVSGIISPSD LPDSPGQTMP
PSRSKTPPPP PPQTVQSKRE VPKNKAPTAE KRESGPKQAA VNAAVQRVQV LPDADTLLHF
ATESTPDGFS CSSSLSALSL DEPFIQKDVE LRIMPPVQEN DNGNETESEQ PEEANESQVK
EAEKPTDSEK DLLDDSDDDD IEILEECIIS AMPTKSSRKA KKPAQTAPKL PPPVARKPSQ
LPVYKLLPSQ NRLQTQKHVS FTPGDDMPRV YCVEGTPINF STATSLSDLT IESPPNELAA
GEGVRAGAQS GEFEKRDTIP TEGRSTDEAQ RVKTPSATIS ELDDNKTEEG DILAECINSA
MPKGKSHKPF RVKKIMDQVQ QASMSSSGAN KNQLDGKKKK PTSPVKPIPQ NTEYRTRVRK
NTDSKNNLNA ERTFSDNKDS KKQNLKNNSK DFNDKLPNNE DRVRGSFTFD SPHHYTPIEG
TPYCFSRNDS LSSLDFDDDD VDLSREKAEL RKGKENKESE AKVTSHTELT SSQQSANKTQ
AVTKHPINRG QSKPMLQKQS TFPQSSKDIP DRGAATDEKL QNFAIENTPV CFSRNSSLSS
LSDIDQENNN NKEGEPVKET EPPDSQGEPS KPQASGYAPK SFHVEDTPVC FSRNSSLSSL
SIDSEDDLLQ ECISSAMPKK KKPSRLKGDN EKHSPRNMSG ILAEDLTLDL KDIQRPDSEH
GLSPDSENFD WKAIQEGANS IVSSLHQAAA AACLSRQASS DSDSILSLKS GISLGSPFHL
TPDQEEKPFT SNKGPRILKP GEKSTLETKK IESENKGIKG GKKVYRSLIT GKVRSNSEIS
SQMKQPLQTN MPSISRGRTM IHIPGVRNSS SSTSPVSKKG PPLKTPASKS PSEGQPATTS
PRGTKPSVKS ELSPVTRQTS QPAGANKGSS RSGSRDSTPS RPAQQPLSRP MQSPGRNSIS
PGRNGISPPN KLSQLPRTSS PSTASTKSSG SGKMSYTSPG RQMSQQNLTK QTGLSKNGSS
IPRSESASKG LNQMNNGNGS NKKVELSRMS STKSSGSESD RSERPVLVRQ STFIKEAPSP
TLRRKLEESA SFESLSPSSR PDSPTRSQAQ TPVLSPSLPD MSLSTHSSVQ SGGWRKLPPN
LSPTIEYNDG RPAKRHDIAR SHSESPSRLP INRSGTWKRE HSKHSSSLPR VSTWRRTGSS
SSILSASSES SEKAKSEDEK HVNSISGTKQ TKENQVSTKG TWRKIKENEI SPTNSTSQTT
SSGAANGAES KTLIYQMAPA VSKTEDVWVR IEDCPINNPR SGRSPTGNTP PVIDTVSEKG
NPNAKDSKDN QGKQNVGNGS APIRTMGLEN RLNSFIQVDA PDQKGTEAKP GQSNPVPVSE
TNESSIAERT PFSSSSSSKH SSPSGTVAAR VTPFNYNPSP RKSSADSTSA RPSQIPTPVN
NNTKKRDSKT DSTESSGTQS PKRHSGSYLV TSV
//
