ID M3W100_FELCA Unreviewed; 563 AA.
AC M3W100;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Differentially expressed in FDCP 8 homolog {ECO:0000313|Ensembl:ENSFCAP00000003503.5};
GN Name=DEF8 {ECO:0000313|Ensembl:ENSFCAP00000003503.5,
GN ECO:0000313|VGNC:VGNC:61426};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000003503.5, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000003503.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000003503.5,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000003503.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000003503.5,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000003503.5}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000003503.5};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DEF8 family.
CC {ECO:0000256|ARBA:ARBA00029450}.
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DR EMBL; AANG04002512; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3W100; -.
DR STRING; 9685.ENSFCAP00000003503; -.
DR Ensembl; ENSFCAT00000003800.6; ENSFCAP00000003503.5; ENSFCAG00000003799.6.
DR VGNC; VGNC:61426; DEF8.
DR eggNOG; KOG1829; Eukaryota.
DR GeneTree; ENSGT00940000159182; -.
DR HOGENOM; CLU_034500_4_0_1; -.
DR InParanoid; M3W100; -.
DR OMA; XKLRQDI; -.
DR Proteomes; UP000011712; Chromosome E2.
DR Bgee; ENSFCAG00000003799; Expressed in uterus and 10 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032418; P:lysosome localization; IEA:Ensembl.
DR GO; GO:0045780; P:positive regulation of bone resorption; IEA:Ensembl.
DR GO; GO:1900029; P:positive regulation of ruffle assembly; IEA:Ensembl.
DR CDD; cd20819; C1_DEF8; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR047983; DEF8_C1.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR025258; RH_dom.
DR PANTHER; PTHR12326:SF3; DIFFERENTIALLY EXPRESSED IN FDCP 8 HOMOLOG; 1.
DR PANTHER; PTHR12326; PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF13901; RH_dom; 1.
DR SMART; SM01175; DUF4206; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 161..212
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT REGION 38..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 563 AA; 65055 MW; FCB581AC9177FBAD CRC64;
MPGSPLRGQQ RAGAPRALGR WDAMEYDEKL ARFRQAHLNP FNKQLGPRQH EQRASEEAPD
FASEEALPEL PPGEPEFHCT ERVMDLGLSE DHFSRPVGLF LASDIQQLRQ AIEECKQVIL
ELPEHSEKQK DAVVRLIHLR LKLQELKDPN EDEPNIRVLL EHRFYKEKSK SVKQTCDKCN
TIIWGLIQTW YTCTGCYYRC HSKCLNLISK PCVRSKVSHQ AEYELNICPE TGLDSQDYRC
AECRAPISLR GVPSEARQCD YTGQYYCSHC HWNDLAIIPA RVVHNWDFEP RKVSRCSMRY
LALMVSRPVL RLREINPLLF NYVEELVEIR KLRQDILLMK PYFITCKEAM EARLLLQLQD
RQHFVENDEM YSVQDLLDAH TGRLSCSLTE THTLFAKHIK LDCERCQAKG FVCELCREGD
VLFPFDSHTS VCTECSAVFH RLVWLRPTLR PGEGATCHSG GHLGSGLCCL IFKALGFDPR
YGVRPRCELN SKFPWEQAPV GLGRVLQPRP QVCTRCLTCS HFPPDLRRSR GQRFLDFLVP
GTLSVLVIFF QTSLGRKKYQ HFY
//
