ID M3W3X1_FELCA Unreviewed; 1283 AA.
AC M3W3X1;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Cell adhesion associated, onco regulated {ECO:0000313|Ensembl:ENSFCAP00000032955.2};
GN Name=CDON {ECO:0000313|Ensembl:ENSFCAP00000032955.2,
GN ECO:0000313|VGNC:VGNC:60716};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000032955.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000032955.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000032955.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000032955.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000032955.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000032955.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000032955.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04002871; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9685.ENSFCAP00000032955; -.
DR PaxDb; 9685-ENSFCAP00000004954; -.
DR Ensembl; ENSFCAT00000037963.3; ENSFCAP00000032955.2; ENSFCAG00000005342.6.
DR VGNC; VGNC:60716; CDON.
DR eggNOG; ENOG502QT4P; Eukaryota.
DR GeneTree; ENSGT00940000157114; -.
DR HOGENOM; CLU_008503_0_0_1; -.
DR InParanoid; M3W3X1; -.
DR OMA; NGCAHLH; -.
DR Proteomes; UP000011712; Chromosome D1.
DR Bgee; ENSFCAG00000005342; Expressed in embryonic head and 10 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
DR GO; GO:0001708; P:cell fate specification; IEA:Ensembl.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0021987; P:cerebral cortex development; IEA:Ensembl.
DR GO; GO:0010172; P:embryonic body morphogenesis; IEA:Ensembl.
DR GO; GO:0060059; P:embryonic retina morphogenesis in camera-type eye; IEA:Ensembl.
DR GO; GO:0002088; P:lens development in camera-type eye; IEA:Ensembl.
DR GO; GO:0007520; P:myoblast fusion; IEA:Ensembl.
DR GO; GO:0007399; P:nervous system development; IBA:GO_Central.
DR GO; GO:0007405; P:neuroblast proliferation; IEA:Ensembl.
DR GO; GO:0030182; P:neuron differentiation; IEA:Ensembl.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR GO; GO:0002052; P:positive regulation of neuroblast proliferation; IEA:Ensembl.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
DR GO; GO:0048643; P:positive regulation of skeletal muscle tissue development; IEA:Ensembl.
DR GO; GO:0051057; P:positive regulation of small GTPase mediated signal transduction; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0014816; P:skeletal muscle satellite cell differentiation; IEA:Ensembl.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl.
DR CDD; cd00063; FN3; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 8.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR44170:SF30; FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 3.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1283
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023938069"
FT TRANSMEM 960..985
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 30..115
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 125..205
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 226..304
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 311..397
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 406..516
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 576..674
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 719..814
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 822..922
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 524..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 671..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 928..953
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1246..1283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..543
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 671..687
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1283 AA; 139531 MW; 32D2A356FBAD35CE CRC64;
MHPDPRPLQT LLYVVTLTIL CPSVNSDLAP SFISEPLSAV QRLGGPVVLH CSAKPVTAHI
SWLHNGKRLD RNMEQIKMHQ GTLTILSLNP SLSGSYQCVA NNSIGAIVSG PATVSTAVLG
DFGSPTKQVI TAEEKSTGFI GCKVPDSNPK AEVRYKIRGK WLKHSTEKYL ILPSGNLQIL
NVSSEDKGSY KCAAFNPVTH ELKVEPIGRK LLVSRPSSDD FHILHPTFSQ ALAVLSHSPV
TLECVVSGVP VSQVHWLKDG QDAVPGSNWR RLHSHLATDS IDPVDSGNYS CIVGNKSGDV
KHVTYMVNVL ENASISKGLQ DQTVPLGATV QFTCEIHGNP TPNRTWFHNA QPVHPSPRHL
TVGNRLKISG VTMEDSGLYQ CVADNGIGFI QSTGRLEIEK GSGLKPVIIT APASTKVVDG
DFVTLSCNAT GVPVPVMRWY DRHGLITSHP SQVLRSKSRK SHLRPGGYDL EPVYFIMSRA
GSSSLYIQAI TQEHAGKYIC EAANEHGATQ SEAVLTVVPF ETNTKAETVT PSNPTQNDKR
DGSEAGLLSS FPGKKRSSAV ESSPEKNTSG ASVPDAPIIL SPPQTYTSDT YNLVWRAGKD
GGLPINAYFV KYRKLDDGVG LVGSWHTVRV PGSENELHLT ELEPSSLYEV LMVARSAAGE
GQPAMLTFRT SKEKTTSSKN TQASSPPMGI PRRPVVSEAA DNFGVVLTDS SRHSGVPEAP
DRPTISTASE TSVYVTWIPR ANGGSPITAF KVEYKRMRTS DWLVAAEDIP PSKLSVEVRS
LEPGSTYKFR VIAINHYGES FRSSASRPYQ VAGFPNRFSN RPITGPHIAY TEAVSDTQIM
LKWTYIPSSN NNTPIQGFYI YYRPTDSDND SDYKRDVVEG SKQWHMIGHL QPETSYDIKM
QCFNEGGESE FSNVMICETK VKRVPGASEY PVKDLSTPPN SPGGGRNVGP ATSPTRSSDM
LYLIVGCVLG VMVLILMAFI AMCLWKNRQQ STIQKYDPPG YLYQGSDING QMVEYTTLPG
TNRINGNVHG SFVSNGGLSN GCSHVHHKIS NGVNGVMNGN LNGGLYAGHT SSLTRTHVDF
EHPRHLVNGG GRYTAVPQSD PLERVSCRNC RNNNRCFTKT SSTFSSSPLP VVPVVAPYPH
DGLEMKPLSH MKVPVCLAST APDCSQSPEE SFKDDTTPRP AQHTCCQDNR NDIDIECTED
TAEFSRGPGA INNLKFQASL QVLKTYTKEG DSYVHSETEN KILSRNPHIL PHGSKDCTEK
TAWSPPGIPL DSPSGVLQQP QET
//
