ID M3W714_FELCA Unreviewed; 1074 AA.
AC M3W714;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 3.
DT 24-JAN-2024, entry version 67.
DE SubName: Full=SEC24 homolog D, COPII coat complex component {ECO:0000313|Ensembl:ENSFCAP00000006559.5};
GN Name=SEC24D {ECO:0000313|Ensembl:ENSFCAP00000006559.5,
GN ECO:0000313|VGNC:VGNC:64970};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000006559.5, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000006559.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000006559.5,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000006559.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000006559.5,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000006559.5}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000006559.5};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle, COPII-coated
CC vesicle membrane {ECO:0000256|ARBA:ARBA00004299}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004299}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004299}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004397}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC {ECO:0000256|ARBA:ARBA00008334}.
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DR EMBL; AANG04001605; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3W714; -.
DR STRING; 9685.ENSFCAP00000006559; -.
DR PaxDb; 9685-ENSFCAP00000006559; -.
DR Ensembl; ENSFCAT00000007071.6; ENSFCAP00000006559.5; ENSFCAG00000007069.6.
DR VGNC; VGNC:64970; SEC24D.
DR eggNOG; KOG1984; Eukaryota.
DR GeneTree; ENSGT00950000182924; -.
DR HOGENOM; CLU_004589_1_0_1; -.
DR InParanoid; M3W714; -.
DR OMA; QNGAHAS; -.
DR Proteomes; UP000011712; Chromosome B1.
DR Bgee; ENSFCAG00000007069; Expressed in liver and 11 other cell types or tissues.
DR GO; GO:0030127; C:COPII vesicle coat; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0070971; C:endoplasmic reticulum exit site; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IBA:GO_Central.
DR GO; GO:0090110; P:COPII-coated vesicle cargo loading; IBA:GO_Central.
DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd01479; Sec24-like; 1.
DR Gene3D; 2.60.40.1670; beta-sandwich domain of Sec23/24; 1.
DR Gene3D; 1.20.120.730; Sec23/Sec24 helical domain; 1.
DR Gene3D; 3.40.20.10; Severin; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR006900; Sec23/24_helical_dom.
DR InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR InterPro; IPR006896; Sec23/24_trunk_dom.
DR InterPro; IPR012990; Sec23_24_beta_S.
DR InterPro; IPR041742; Sec24-like_trunk_dom.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR006895; Znf_Sec23_Sec24.
DR PANTHER; PTHR13803:SF6; PROTEIN TRANSPORT PROTEIN SEC24D; 1.
DR PANTHER; PTHR13803; SEC24-RELATED PROTEIN; 1.
DR Pfam; PF00626; Gelsolin; 1.
DR Pfam; PF08033; Sec23_BS; 1.
DR Pfam; PF04815; Sec23_helical; 1.
DR Pfam; PF04811; Sec23_trunk; 1.
DR Pfam; PF04810; zf-Sec23_Sec24; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 2.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR SUPFAM; SSF81811; Helical domain of Sec23/24; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 402..440
FT /note="Zinc finger Sec23/Sec24-type"
FT /evidence="ECO:0000259|Pfam:PF04810"
FT DOMAIN 479..722
FT /note="Sec23/Sec24 trunk"
FT /evidence="ECO:0000259|Pfam:PF04811"
FT DOMAIN 728..811
FT /note="Sec23/Sec24 beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF08033"
FT DOMAIN 824..923
FT /note="Sec23/Sec24 helical"
FT /evidence="ECO:0000259|Pfam:PF04815"
FT DOMAIN 942..1016
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT REGION 72..308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..224
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1074 AA; 117821 MW; B1F2F4F8A16617BB CRC64;
MEHQRLTSGD SGVVWTKEGW ESRLILLSGF FCRAIPWNDI FIMSQQGYVA TPPYSQSQPG
IGLSPPHYGH YVDPSHAGSP PGMMKPAGPL GAAVPGGMLP QGPSPPGPHQ FGQNGAHAQG
HPPQRFPGPP PVNSAASSYA PYSPSTQSSY PSPASTSSIT QLGSQLNAMH INSYGSGMAP
PGQGPPGPPP APSFQGPTRP PQPSIMQPGS QVLPPPPTTL NGPGASPLPP STHRQDGFPG
PAPLNTQYQP PPLPGQSLGT GYPPQQANYG PQMAGGQLSY PGGFPGGPAQ MAGPPQLQKK
LDPDSIPSPI QVIENDRATR GGQVYATNTR GQVPPLVTTD CVIQDQGSAS PRYIRCTTYC
FPCTSDMAKQ AQIPLAAVIK PFATVPSNET PLYLVNHGEN GPVRCNRCKA YMCPFMQFIE
GGRRYQCGFC NCVNDVPPFY FQHLDHIGRR LDHYEKPELS LGSYEYVATL DYCRKNKPPN
PPAFIFMIDV SYSNIKNGLV KLICEELKTV LEKLPKEEQE ETSAIRVGFI TYNKVLHFFN
VKSNLAQPQM MVVTDVGEVF VPLLDGFLVN YQESQSVIHN LLDQIPEMFA DSNENETVFA
PVIQAGMEAL KAADCPGKLF IFHSSLPTAE APGKLKNRDD KKLINTDKEK ILFQPQTNVY
DALAKDCVAH GCCVTLFLFP SQYVDVASLG LVPHLTGGTL YKYNNFQMHM DSQQFLNDLR
NDIEKKIGFD AIMRVRTSTG FRATDFFGGI FMNNTTDVEM AAIDCDKAVT VEFKHDDKLG
EDSGALIQCA VLYTTVGGQR RLRIHNLGLN CSSQLADLYK SCETDALINF FAKSAFKAVL
YQPLKVIREI LVNQTAHMLA CYRKNCASPS AASQLILPDS MKVLPVYMNC LLKNCVLLSR
PEISTDERAY QRQLVMTMGV ADSQLFFYPQ LLPIHTLDIK STTLPAAIRC SEARLSEEGI
FLLANGLNMF LWLGVSSPPE LIQGIFNVPS FAHVNTDMTL LPEIGNPYSQ TLRMIMSIIQ
QKRPYSMKLT IVKQREQPEM VFRQYLVEDK GLYGGSSYVD FLCCVHKEIC QLLN
//
