ID M3W8E4_FELCA Unreviewed; 286 AA.
AC M3W8E4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 2.
DT 24-JAN-2024, entry version 59.
DE SubName: Full=Thrombopoietin {ECO:0000313|Ensembl:ENSFCAP00000007222.2};
GN Name=THPO {ECO:0000313|Ensembl:ENSFCAP00000007222.2,
GN ECO:0000313|VGNC:VGNC:66171};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000007222.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000007222.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000007222.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000007222.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000007222.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000007222.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000007222.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the EPO/TPO family.
CC {ECO:0000256|ARBA:ARBA00005782}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AANG04001816; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3W8E4; -.
DR Ensembl; ENSFCAT00000007800.4; ENSFCAP00000007222.2; ENSFCAG00000007798.4.
DR VGNC; VGNC:66171; THPO.
DR eggNOG; ENOG502S9T0; Eukaryota.
DR GeneTree; ENSGT00390000006294; -.
DR HOGENOM; CLU_039844_0_0_1; -.
DR Proteomes; UP000011712; Chromosome C2.
DR Bgee; ENSFCAG00000007798; Expressed in liver and 5 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005125; F:cytokine activity; IEA:InterPro.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0008283; P:cell population proliferation; IEA:InterPro.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR019767; EPO/TPO_CS.
DR InterPro; IPR001323; EPO_TPO.
DR InterPro; IPR003978; Thrombopoietin.
DR PANTHER; PTHR10560; THROMBOPOIETIN; 1.
DR PANTHER; PTHR10560:SF0; THROMBOPOIETIN; 1.
DR Pfam; PF00758; EPO_TPO; 1.
DR PRINTS; PR01485; THROMBOPTN.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
DR PROSITE; PS00817; EPO_TPO; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..286
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016298002"
SQ SEQUENCE 286 AA; 31902 MW; 49EC7410CFC13891 CRC64;
MELTELLLVV MLLLTARLNL CLPAPPACDP RLLNKLLRDS HVLHSKLSQC PDVNPLSTPV
LLPAVDFSLG EWKTQKEQTK AQDVLGAATL LLEGVMAARG QLGPTCLSSL LGQLSGQVRL
LLGALQGLLG TQLPPQGRTT AHKDPNAIFL SFQQLLRGKD FWIFGDRLPC RSQNYWLWTS
EEAAGIQSQD SWSAEPNLQV PRPNPWTREQ DTRTLDWNSW TLSWTLTQGS RSPRHPSRNF
RHELPATRPL AWIFSFPNPS SYWAIHTLLS FTHLTHSPDP APASTS
//
