ID M3WC78_FELCA Unreviewed; 713 AA.
AC M3WC78;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 24-JAN-2024, entry version 66.
DE SubName: Full=Mitochondrial intermediate peptidase {ECO:0000313|Ensembl:ENSFCAP00000009124.4};
GN Name=MIPEP {ECO:0000313|Ensembl:ENSFCAP00000009124.4,
GN ECO:0000313|VGNC:VGNC:68260};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000009124.4, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000009124.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000009124.4,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000009124.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000009124.4,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000009124.4}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000009124.4};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU003435};
CC Note=Binds 1 zinc ion. {ECO:0000256|RuleBase:RU003435};
CC -!- SIMILARITY: Belongs to the peptidase M3 family.
CC {ECO:0000256|ARBA:ARBA00006040, ECO:0000256|RuleBase:RU003435}.
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DR EMBL; AANG04001781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003980308.1; XM_003980259.4.
DR AlphaFoldDB; M3WC78; -.
DR STRING; 9685.ENSFCAP00000009124; -.
DR PaxDb; 9685-ENSFCAP00000009124; -.
DR Ensembl; ENSFCAT00000009837.6; ENSFCAP00000009124.4; ENSFCAG00000009835.6.
DR GeneID; 101084847; -.
DR KEGG; fca:101084847; -.
DR CTD; 4285; -.
DR VGNC; VGNC:68260; MIPEP.
DR eggNOG; KOG2090; Eukaryota.
DR GeneTree; ENSGT00950000183171; -.
DR HOGENOM; CLU_001805_0_2_1; -.
DR OMA; ALMFEYM; -.
DR OrthoDB; 735202at2759; -.
DR Proteomes; UP000011712; Chromosome A1.
DR Bgee; ENSFCAG00000009835; Expressed in adult mammalian kidney and 10 other cell types or tissues.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd06457; M3A_MIP; 1.
DR Gene3D; 1.10.1370.40; -; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 1.10.1370.10; Neurolysin, domain 3; 1.
DR InterPro; IPR033851; M3A_MIP.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR024077; Neurolysin/TOP_dom2.
DR InterPro; IPR045090; Pept_M3A_M3B.
DR InterPro; IPR001567; Pept_M3A_M3B_dom.
DR PANTHER; PTHR11804:SF79; MITOCHONDRIAL INTERMEDIATE PEPTIDASE; 1.
DR PANTHER; PTHR11804; PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED; 1.
DR Pfam; PF01432; Peptidase_M3; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003435};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU003435};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000256|RuleBase:RU003435};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU003435};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU003435}.
FT DOMAIN 255..697
FT /note="Peptidase M3A/M3B catalytic"
FT /evidence="ECO:0000259|Pfam:PF01432"
SQ SEQUENCE 713 AA; 80395 MW; 81E0021C1394F7B4 CRC64;
MLCAGRLGGL GSRAAPLWPG RAGSRGLGAR IRARGVSTSW FPVGAAFNVK PQGRRLDLFG
ERRGLFGVPE LSAPEGFRVA QENALRKADL LVERVCSVAP GPQTVLIFDE LSDSLCRVAD
LADFVKIAHP EPAFREAAEE ACTSIGTAVE KLNTNVELYR SLQKLLADKK LVDSLDPETR
RVAELFMFDF EISGIHLDKE KRKRAVDLNV KILDLSNTFL MGTNFPNKIE KHLLPEHIRQ
NFVVAGNHVI VDGLHAESPD DLVREAAYKI FLYPNAGQLR CLEELLSNRD LLAKLVGYST
YSHRALQGTI AQSPETVMQF LEKLSEKLSE RTIRDFEMIR GMKMKLNPQN SELMPWDPPY
YSGVIRAERY NIEPSLYCPF FSLGACMEGL NTLFGRLLGI TLYAEQPAKG EVWCEGVRKL
AVVHESEGLL GYIYCDFFQR AGKPHQDCHF TIRGGRLKED GDYQLPVVVL MLNLPHPSRN
LPTLLTPGMM ENLFHEMGHA MHSMLGRTRY QHVTGTRCPT DFAEVPSILM EYFANDHRVV
SQFARHYQTG QSLPKNMVSR LCESKKVGAA ADMQLQVFYA ALDQIYHGKH PLTASTTDIL
RETQEKFYGL PYVPNTAWQL RFSHLVGYGA KYYSYLMSRA VASMVWKECF RRDPFNRTAG
ERYRREMLAH GGGKEPMLMV QGMLQKCPSI DDFVSALVSD LDPDFETFLM DSE
//
