ID M3WEA2_FELCA Unreviewed; 562 AA.
AC M3WEA2;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 3.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Tudor and KH domain containing {ECO:0000313|Ensembl:ENSFCAP00000010200.4};
GN Name=TDRKH {ECO:0000313|Ensembl:ENSFCAP00000010200.4,
GN ECO:0000313|VGNC:VGNC:66052};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000010200.4, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000010200.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010200.4,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000010200.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010200.4,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000010200.4}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010200.4};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04001280; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3WEA2; -.
DR STRING; 9685.ENSFCAP00000010200; -.
DR PaxDb; 9685-ENSFCAP00000010200; -.
DR Ensembl; ENSFCAT00000010983.5; ENSFCAP00000010200.4; ENSFCAG00000010980.5.
DR VGNC; VGNC:66052; TDRKH.
DR eggNOG; KOG2279; Eukaryota.
DR GeneTree; ENSGT00940000159364; -.
DR HOGENOM; CLU_023629_1_0_1; -.
DR InParanoid; M3WEA2; -.
DR OMA; NMVQEMT; -.
DR Proteomes; UP000011712; Chromosome C1.
DR Bgee; ENSFCAG00000010980; Expressed in testis and 9 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0043186; C:P granule; IBA:GO_Central.
DR GO; GO:0071546; C:pi-body; IEA:Ensembl.
DR GO; GO:0071547; C:piP-body; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009566; P:fertilization; IEA:Ensembl.
DR GO; GO:0007140; P:male meiotic nuclear division; IEA:Ensembl.
DR GO; GO:0030719; P:P granule organization; IBA:GO_Central.
DR GO; GO:0034587; P:piRNA processing; IBA:GO_Central.
DR GO; GO:0007283; P:spermatogenesis; IBA:GO_Central.
DR CDD; cd22428; KH-I_TDRKH_rpt1; 1.
DR CDD; cd22429; KH-I_TDRKH_rpt2; 1.
DR CDD; cd20412; Tudor_TDRD2; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 2.40.50.90; -; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR InterPro; IPR047382; KH-I_TDRKH_rpt1.
DR InterPro; IPR047381; KH-I_TDRKH_rpt2.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR047380; TDRD2-like_tudor.
DR InterPro; IPR002999; Tudor.
DR PANTHER; PTHR22948:SF18; TUDOR AND KH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22948; TUDOR DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF00013; KH_1; 2.
DR Pfam; PF00567; TUDOR; 1.
DR SMART; SM00322; KH; 2.
DR SMART; SM00333; TUDOR; 1.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 2.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS50084; KH_TYPE_1; 2.
DR PROSITE; PS50304; TUDOR; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT DOMAIN 354..413
FT /note="Tudor"
FT /evidence="ECO:0000259|PROSITE:PS50304"
FT REGION 223..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 562 AA; 61922 MW; C99D17B97D233F00 CRC64;
MSTERTSWTS LSTIQKIALG LGIPASATVA YILYRRYRES REERLTFVGE DDIEIEMRVP
QEAVKLIIGR QGANIKQLRK QTGARIDVDT EDVGDERVLL ISGFPVQVCK AKAAIHQILT
ENTPVSEQLS VPQRSVGRII GRGGETIRSI CKASGAKITC DKESEGTLLL SRLIKISGTQ
KEVAAAKHLI LEKVSEDEEL RKRIAHSAET RVPRKQPISV RREEAIESGG AGEPALWKST
DTGDGPEPAT PLRVPPRKGS GDMAVEGPEG AWEKPNGGSF QKSGAQTSPE MSMFEIPSPD
FSFHADEFLE VYVSASEHPN HFWIQIIGSR SLQLDKLVSE MTQHYENSLP EDLTVHVGDI
VAAPLPTNGS WYRARVLGTL ENGNLDLYFV DFGDNGDCPL KDLRALRSDF LSLPFQAIEC
SLARIAPSGE QWEEEALDEF DRLTHCADWK PLVAKISSYV QTGISTWPKI YLYDTSNGKK
LDIGLELVRK GYAVELPEDM EENRAIPDML HDVATETEVS LGSMLAETRK SPGEIANTLS
CLSLSEAASV SGDDNLEEDY LL
//
