ID M3WJV4_FELCA Unreviewed; 848 AA.
AC M3WJV4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=MALT1 paracaspase {ECO:0000313|Ensembl:ENSFCAP00000012971.4};
GN Name=MALT1 {ECO:0000313|Ensembl:ENSFCAP00000012971.4,
GN ECO:0000313|VGNC:VGNC:68142};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000012971.4, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000012971.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000012971.4,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000012971.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000012971.4,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000012971.4}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000012971.4};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04003548; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003995307.3; XM_003995258.4.
DR AlphaFoldDB; M3WJV4; -.
DR STRING; 9685.ENSFCAP00000012971; -.
DR PaxDb; 9685-ENSFCAP00000012971; -.
DR Ensembl; ENSFCAT00000013991.6; ENSFCAP00000012971.4; ENSFCAG00000013987.6.
DR GeneID; 101088885; -.
DR KEGG; fca:101088885; -.
DR CTD; 10892; -.
DR VGNC; VGNC:68142; MALT1.
DR eggNOG; ENOG502QUZM; Eukaryota.
DR GeneTree; ENSGT00390000018044; -.
DR HOGENOM; CLU_014796_0_0_1; -.
DR InParanoid; M3WJV4; -.
DR OMA; CLMSDGP; -.
DR OrthoDB; 3080800at2759; -.
DR Proteomes; UP000011712; Chromosome D3.
DR Bgee; ENSFCAG00000013987; Expressed in embryonic head and 10 other cell types or tissues.
DR GO; GO:0032449; C:CBM complex; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR GO; GO:0002096; C:polkadots; IEA:Ensembl.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0019209; F:kinase activator activity; IEA:Ensembl.
DR GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:Ensembl.
DR GO; GO:0042113; P:B cell activation; IBA:GO_Central.
DR GO; GO:0001923; P:B-1 B cell differentiation; IEA:Ensembl.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0051168; P:nuclear export; IEA:Ensembl.
DR GO; GO:0032731; P:positive regulation of interleukin-1 beta production; IEA:Ensembl.
DR GO; GO:0032743; P:positive regulation of interleukin-2 production; IEA:Ensembl.
DR GO; GO:0002726; P:positive regulation of T cell cytokine production; IEA:Ensembl.
DR GO; GO:2000321; P:positive regulation of T-helper 17 cell differentiation; IEA:Ensembl.
DR GO; GO:0051603; P:proteolysis involved in protein catabolic process; IEA:Ensembl.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0050856; P:regulation of T cell receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0009620; P:response to fungus; IEA:Ensembl.
DR GO; GO:0042098; P:T cell proliferation; IEA:Ensembl.
DR GO; GO:0050852; P:T cell receptor signaling pathway; IBA:GO_Central.
DR CDD; cd08783; Death_MALT1; 1.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.3360; -; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR037940; MALT1_Death.
DR InterPro; IPR041077; MALT1_Ig.
DR InterPro; IPR033540; MALT1_IG-like_dom_sf.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR001309; Pept_C14_p20.
DR PANTHER; PTHR22576; MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1/PARACASPASE; 1.
DR PANTHER; PTHR22576:SF40; MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1; 1.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF18703; MALT1_Ig; 1.
DR Pfam; PF00656; Peptidase_C14; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50208; CASPASE_P20; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 146..222
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 251..329
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 364..442
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
FT REGION 18..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..50
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 848 AA; 93916 MW; 99C4C65636A2AB68 CRC64;
MRPAGAAAVA GSSARDASLC GELLQAPPPP ASQPPPAAPS GPPLPAPSAT LNRLPEPLLR
RLSGSLDRAP EGRGWRRLAE VAGSRGRLRL SCLDLEQCSL KVLEPEGSPS LCLLKLMGEK
GCTVTELSDF LQAMEHTEVL GLLSPPGIKI TVNPESKAVL AGQFVKLCCR ATGHPFVQYQ
WFKMNKEIPN GNASELIFNT VHVKDAGFYV CRVNNNFTFE FSQWSQLDVC DVTEVTGNLQ
GSLDGISESK LQICVEPRSQ KLMPGSTLLL QCVAVGSPIP HYQWFKNESP LIHETKKLYM
VPYVDLEHQG TYWCHVYNDR DSQDSKKVEI IIGRTDAVEC TEDELNNLGC PDHEEQTGDQ
PLAKDKVALL IGNMNYWEHP KLKAPLVDVY ELTNLLRQLD FKVVSLLDLT EYEMRNAVDE
FLLLLDKGVY GLLYYAGHGY ENFGNSFMVP VDAPNPYRSE NCLCVQNILK LMQEKETGLN
VFLLDMCRKR NDYDDTIPIL DALKVTANIV FGYATCQGAE AFEIQHSGLA NGIFMKFLKD
RLLEDKKITV LLDEVAEDMG KCHLTKGKQA LEIRSSLSEK RALTDPIQGT AYSAESLVRN
LQWAKAHELP ESMCLKFQCG VQIQLGFAAE FSNVMIIYTS IVHKPPDVVM CDAYVTDFPL
DLDIDPKAAN KGTPEETGSY LVSKDLPKQC LYTRLSSLQK LKEHLIFTVC VSYQYSGLED
TVEEKQEVNV GKPLIAKLDI HRGLGRKTCF QTCVMCNGPY PSPASTSPGA GQYHSSQDSF
HALYHSHLGN SSSVLPSDSC HCSRTADAFI SSPHSHRDSC RFGRSNVPVE TTDEMPFSLS
DGLRISDK
//
