ID M3WRE8_FELCA Unreviewed; 193 AA.
AC M3WRE8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Dimethylarginine dimethylaminohydrolase 1 {ECO:0000313|Ensembl:ENSFCAP00000016931.2};
GN Name=DDAH1 {ECO:0000313|Ensembl:ENSFCAP00000016931.2,
GN ECO:0000313|VGNC:VGNC:61384};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000016931.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000016931.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000016931.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000016931.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000016931.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000016931.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000016931.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DDAH family.
CC {ECO:0000256|ARBA:ARBA00008532}.
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DR EMBL; AANG04003279; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3WRE8; -.
DR PaxDb; 9685-ENSFCAP00000016931; -.
DR Ensembl; ENSFCAT00000032276.4; ENSFCAP00000016931.2; ENSFCAG00000029407.4.
DR VGNC; VGNC:61384; DDAH1.
DR eggNOG; ENOG502QWPA; Eukaryota.
DR GeneTree; ENSGT00940000157892; -.
DR HOGENOM; CLU_115111_0_0_1; -.
DR Proteomes; UP000011712; Chromosome C1.
DR Bgee; ENSFCAG00000029407; Expressed in adult mammalian kidney and 9 other cell types or tissues.
DR GO; GO:0016403; F:dimethylargininase activity; IEA:UniProtKB-EC.
DR InterPro; IPR033199; DDAH-like.
DR PANTHER; PTHR12737; DIMETHYLARGININE DIMETHYLAMINOHYDROLASE; 1.
DR PANTHER; PTHR12737:SF17; N(G),N(G)-DIMETHYLARGININE DIMETHYLAMINOHYDROLASE 1; 1.
DR SUPFAM; SSF55909; Pentein; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT ACT_SITE 81
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR633199-1"
FT ACT_SITE 182
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR633199-1"
SQ SEQUENCE 193 AA; 21547 MW; B727FE28E34AE2C7 CRC64;
MAVWWQSAMV DMMKEALEKL QLNLVEMKDE NATLDGGDVL FTGREFFVGL SKRTNQRGAE
ILADTFKDYA VSTVPVADAL HLKSFCSMAG PNLIAIGSSE SAQKALKIMQ QMSDHRYDKL
TVPDDMAANC IYLNIPNKGH VLLHRTPEEY PESAKVYEKL KDHMLIPVSH SELEKVDGLL
TCCSILINKK VDS
//
