ID M3WW81_FELCA Unreviewed; 335 AA.
AC M3WW81;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Protein phosphatase 1 regulatory subunit 42 {ECO:0000256|ARBA:ARBA00044175};
DE AltName: Full=Leucine-rich repeat-containing protein 67 {ECO:0000256|ARBA:ARBA00044209};
GN Name=PPP1R42 {ECO:0000313|Ensembl:ENSFCAP00000018619.3,
GN ECO:0000313|VGNC:VGNC:64325};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000018619.3, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000018619.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000018619.3,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000018619.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000018619.3,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000018619.3}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000018619.3};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
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DR EMBL; AANG04003518; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_011289670.1; XM_011291368.2.
DR AlphaFoldDB; M3WW81; -.
DR STRING; 9685.ENSFCAP00000018619; -.
DR PaxDb; 9685-ENSFCAP00000018619; -.
DR Ensembl; ENSFCAT00000029603.4; ENSFCAP00000018619.3; ENSFCAG00000022821.4.
DR GeneID; 101096135; -.
DR KEGG; fca:101096135; -.
DR CTD; 286187; -.
DR VGNC; VGNC:64325; PPP1R42.
DR eggNOG; KOG2769; Eukaryota.
DR GeneTree; ENSGT00940000158260; -.
DR HOGENOM; CLU_062444_0_0_1; -.
DR InParanoid; M3WW81; -.
DR OMA; NNCISCM; -.
DR OrthoDB; 3670620at2759; -.
DR Proteomes; UP000011712; Chromosome F2.
DR Bgee; ENSFCAG00000022821; Expressed in testis and 9 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0002177; C:manchette; IEA:Ensembl.
DR GO; GO:0003779; F:actin binding; IEA:Ensembl.
DR GO; GO:0070840; F:dynein complex binding; IEA:Ensembl.
DR GO; GO:0015631; F:tubulin binding; IEA:Ensembl.
DR CDD; cd21340; PPP1R42; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR46652; LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46652:SF8; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 42; 1.
DR Pfam; PF12799; LRR_4; 1.
DR Pfam; PF14580; LRR_9; 1.
DR SMART; SM00365; LRR_SD22; 4.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 4.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT REGION 301..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 335 AA; 38357 MW; 3B8E14CDACD5D497 CRC64;
MVRLTLDLIA KSNNLKPRKE ETTSRYLKKI THLNFSDKNI DTIGDLSPCK SLSVLYLYDN
RISEITNLNY ATNLTHLYLQ NNCISCIENL RSLKKLEKLY LGSNYIAVIE GLEGLEGLRE
LHVESQRLPL GEKLLFDPRT LHSLGKSLSI LNISNNNIDD IRDLEILENL NQLIAVDNQL
LHVKDLEFLL NKLMKLWKMD LNGNPVCLKP KYRDRLILVS KSLEFLDGKE IKNTERQFLI
NWKASKDAKK ISKKKNSKNE DASNSYISNF ETIHHIVPVY YPQVGKPKLV FFSDIPRNLA
NGNASSESSQ EDKPKIAEDM GNPSLKECES LLTKK
//
