ID M3WY43_FELCA Unreviewed; 239 AA.
AC M3WY43;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=palmitoyl-protein hydrolase {ECO:0000256|ARBA:ARBA00012423};
DE EC=3.1.2.22 {ECO:0000256|ARBA:ARBA00012423};
GN Name=LYPLAL1 {ECO:0000313|Ensembl:ENSFCAP00000019283.1,
GN ECO:0000313|VGNC:VGNC:63344};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000019283.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000019283.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000019283.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000019283.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000019283.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000019283.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000019283.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. AB hydrolase 2
CC family. {ECO:0000256|ARBA:ARBA00006499}.
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DR EMBL; AANG04002036; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003999558.1; XM_003999509.3.
DR AlphaFoldDB; M3WY43; -.
DR STRING; 9685.ENSFCAP00000019283; -.
DR PaxDb; 9685-ENSFCAP00000019283; -.
DR Ensembl; ENSFCAT00000026109.4; ENSFCAP00000019283.1; ENSFCAG00000024235.4.
DR GeneID; 101094568; -.
DR KEGG; fca:101094568; -.
DR CTD; 127018; -.
DR VGNC; VGNC:63344; LYPLAL1.
DR eggNOG; KOG2112; Eukaryota.
DR GeneTree; ENSGT00940000159171; -.
DR HOGENOM; CLU_049413_3_6_1; -.
DR InParanoid; M3WY43; -.
DR OMA; LEYPHIK; -.
DR OrthoDB; 4670340at2759; -.
DR Proteomes; UP000011712; Chromosome F1.
DR Bgee; ENSFCAG00000024235; Expressed in uterus and 10 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IBA:GO_Central.
DR GO; GO:0008474; F:palmitoyl-(protein) hydrolase activity; IBA:GO_Central.
DR GO; GO:0160049; P:negative regulation of cGAS/STING signaling pathway; IEA:Ensembl.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR003140; PLipase/COase/thioEstase.
DR PANTHER; PTHR10655:SF71; LYSOPHOSPHOLIPASE-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR10655; LYSOPHOSPHOLIPASE-RELATED; 1.
DR Pfam; PF02230; Abhydrolase_2; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 14..226
FT /note="Phospholipase/carboxylesterase/thioesterase"
FT /evidence="ECO:0000259|Pfam:PF02230"
SQ SEQUENCE 239 AA; 26537 MW; 4C469A7978E164B3 CRC64;
MAAASGSIRV QRCMVSPAGR HSASLIFLHG SGDSGQGLRT WIKQVLNQDL TFQHIKIIYP
TAPPRPYTPM KGGISNVWFD RFKISNDCPE HLESINVMCK VLTDLIDDEV KSGIKKNRIL
IGGFSMGGCM AMHLVYRNHQ DVAGVFALSS FLNKTSAVYQ ALQESDGVLP ELFQCHGTAD
ELVPHSWGEE TNSVLKSLRV STKFHSLPGV YHELGKAELE ELKSWILQKL PGEMEKQNE
//
