ID M3WZ57_FELCA Unreviewed; 1673 AA.
AC M3WZ57;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Clathrin heavy chain {ECO:0000256|PIRNR:PIRNR002290};
GN Name=CLTCL1 {ECO:0000313|Ensembl:ENSFCAP00000019647.4,
GN ECO:0000313|VGNC:VGNC:60985};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000019647.4, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000019647.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000019647.4,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000019647.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000019647.4,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000019647.4}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000019647.4};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Clathrin is the major protein of the polyhedral coat of
CC coated pits and vesicles. {ECO:0000256|PIRNR:PIRNR002290}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane, coated pit
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the clathrin heavy chain family.
CC {ECO:0000256|ARBA:ARBA00009535, ECO:0000256|PIRNR:PIRNR002290}.
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DR EMBL; AANG04000826; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_011286191.1; XM_011287889.2.
DR STRING; 9685.ENSFCAP00000019647; -.
DR PaxDb; 9685-ENSFCAP00000002525; -.
DR Ensembl; ENSFCAT00000031197.4; ENSFCAP00000019647.4; ENSFCAG00000002747.6.
DR GeneID; 101081257; -.
DR KEGG; fca:101081257; -.
DR CTD; 8218; -.
DR VGNC; VGNC:60985; CLTCL1.
DR GeneTree; ENSGT00950000183166; -.
DR HOGENOM; CLU_002136_0_0_1; -.
DR InParanoid; M3WZ57; -.
DR OMA; HTRVMDY; -.
DR OrthoDB; 5474327at2759; -.
DR Proteomes; UP000011712; Chromosome D3.
DR Bgee; ENSFCAG00000002747; Expressed in testis and 10 other cell types or tissues.
DR GO; GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
DR GO; GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
DR GO; GO:0071439; C:clathrin complex; IBA:GO_Central.
DR GO; GO:0045334; C:clathrin-coated endocytic vesicle; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR GO; GO:0097443; C:sorting endosome; IEA:Ensembl.
DR GO; GO:0005819; C:spindle; IEA:Ensembl.
DR GO; GO:0005802; C:trans-Golgi network; IEA:Ensembl.
DR GO; GO:0032051; F:clathrin light chain binding; IBA:GO_Central.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0046326; P:positive regulation of glucose import; IEA:Ensembl.
DR GO; GO:0006898; P:receptor-mediated endocytosis; IBA:GO_Central.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:Ensembl.
DR Gene3D; 1.25.40.730; -; 1.
DR Gene3D; 2.130.10.110; Clathrin heavy-chain terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR015348; Clathrin_H-chain_linker_core.
DR InterPro; IPR016025; Clathrin_H-chain_N.
DR InterPro; IPR022365; Clathrin_H-chain_propeller_rpt.
DR InterPro; IPR016341; Clathrin_heavy_chain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR10292:SF6; CLATHRIN HEAVY CHAIN 2; 1.
DR PANTHER; PTHR10292; CLATHRIN HEAVY CHAIN RELATED; 1.
DR Pfam; PF00637; Clathrin; 7.
DR Pfam; PF09268; Clathrin-link; 1.
DR Pfam; PF13838; Clathrin_H_link; 1.
DR Pfam; PF01394; Clathrin_propel; 4.
DR PIRSF; PIRSF002290; Clathrin_H_chain; 1.
DR SMART; SM00299; CLH; 7.
DR SUPFAM; SSF48371; ARM repeat; 6.
DR SUPFAM; SSF50989; Clathrin heavy-chain terminal domain; 1.
DR PROSITE; PS50236; CHCR; 7.
PE 3: Inferred from homology;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176, ECO:0000256|PIRNR:PIRNR002290};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329,
KW ECO:0000256|PIRNR:PIRNR002290};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR002290};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 331..354
FT /note="Clathrin heavy chain linker core motif"
FT /evidence="ECO:0000259|Pfam:PF09268"
SQ SEQUENCE 1673 AA; 189879 MW; 766C44BB966A533A CRC64;
MAQILPIRFQ EHFQLQNLGI NPANIGFSTL TMESDKFICV REKVGEQAQV VIVDMSDPMA
PIRRPISAES AIMNPASKVI ALKAGKTLQI FNIEMKSKMK SHTMAEEVIF WKWVSVNTVA
LVTETTVYHW SMEGDSQPVK MFDRHASLAG CQMIHYRTDE YQKWLLLVGI SAQQNRVVGA
MQLYSVDRKV SQPIEGHAAA FAEFKSEGNA KPATLFCFAV RSPTGGKLHI IEVGQPAAGN
QPFVKKAVDV FFPPEAQTDF PVAMQIGGKH GVIYLITKYG YLHMYDLESG VCIYMNRISA
DTIFVTAPHE STSGIIGVNK KGQVLSVCVE EDNIVNYATS VLQNPDLGLR LAIRSNLAGA
EELFVRKFTT LFAQGSYAEA AKVAASAPKG VLRTSDTVRK FQSIPAQPGQ ASPLLQYFGI
LLDQGQLNKL ESLELCRLVL QQGRKQLLEK WLKEDKLECS EELGDLVKTA DPTLALSVYL
RANVPSKVIQ CFAETGQFQK IVLYAKKVGY TPDWIFLLRS VMRISPDQGL QFSQMLVRDE
EPLANIDQIV DVFMENSLIQ QCTSFLLDAL KNNRPAEGHL QTRLLEMNLI HAPQVADAIL
GNQMFTHYDR AHIAQLCEKA GLLQRALEHY TDLYDIKRAV VHTHLLNPEW LVSFFGSLSV
EDSLACLHAL LSASIRQNLQ LCVQVASKYH EQLGTQSLVE LFESFKSYEG LFYFLGSIVN
FSQDPDVHLK YIQAACKTGQ IKEVERICRE SNCYNPERVK NFLKEAKLTD QLPLIIVCDR
FDFVHDLVLY LYRNNLQKYI EIYVQKVNPS RIPAVVGGLL DVDCSEEVIK NLIMVVRGQF
STDELVAEVE KRNRLKLLLP WLESRSHEGC EEPATHNALA KIYIDSNNSP ERFLRENAYY
DSRVVGRYCE KRDPHLACVA YERGQCDLEL IKVCNENSLF KSEARYLVRR KDPELWAHVL
EETNPSRRQL IDQVVQTALS ETQDPEEVSV TVKAFMTADL PNELIELLEK IVLDNSVFSE
HRNLQNLLIL TAIKADRTRV MEYISRLDNY DAPDIANIAV SSALYEEAFT IFRKFDVNAS
AIQVLIEHIG NLDRAYEFAE RCNEPAVWSQ LACAQLQKDL VKEAIDSYIR ADDPSSYLEV
VQAASRNNNW EDLVKFLQMA RRKGRESYIE TELIFALAKT GRLSELEDCI NGPNNAHIQQ
VGDRCYEEGM YEAAKLLYSS VSNFARLAST LVHLGEYQAA VDSSRKANST RTWKEVCFAC
VDGQEFRLAQ LCGLHIVIHA DELEELIRYY QDRGYFEELI SLLEAALGLE RAHMGMFTEL
AILYSKFKPQ KMPEHLELFW SRVNIPKVLR AAEQAHLWAE LVFLYDKYEE YDNAVLTMIN
HPTDAWREGQ FKDVIAKVAN VELYYKALQF YLDYKPLLIN DLLLVLAPRL DHTRTVGFFS
KAGQLPLVKP YLRSVQSHNN KSVNEALNHL LTEEEDYQGL RASIDAYDNF DNIALAQRLE
KHQLIEFRRI AAYLYKGNNR WAQSVELCKK DHLYKDAMQH AAESRDAELA EKLLQWFLEE
GKRECFAASL FTCYDLLPPD VVLELAWRHN LVDLAMPYFI QVMREYLSKV DRLDASESLR
KQEEHVVEPA PLLFGQQLML TAGPAAGPAP AGFPYGYAAA PAFAQPPVYG FSV
//
