ID M3XCZ3_FELCA Unreviewed; 231 AA.
AC M3XCZ3;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 3.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Interleukin 22 receptor subunit alpha 2 {ECO:0000313|Ensembl:ENSFCAP00000024499.3};
GN Name=IL22RA2 {ECO:0000313|Ensembl:ENSFCAP00000024499.3,
GN ECO:0000313|VGNC:VGNC:62906};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000024499.3, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000024499.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000024499.3,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000024499.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000024499.3,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000024499.3}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000024499.3};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; AANG04000169; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3XCZ3; -.
DR STRING; 9685.ENSFCAP00000024499; -.
DR PaxDb; 9685-ENSFCAP00000024499; -.
DR Ensembl; ENSFCAT00000032339.4; ENSFCAP00000024499.3; ENSFCAG00000021984.4.
DR VGNC; VGNC:62906; IL22RA2.
DR eggNOG; ENOG502S2NT; Eukaryota.
DR GeneTree; ENSGT00940000161124; -.
DR HOGENOM; CLU_081158_1_0_1; -.
DR InParanoid; M3XCZ3; -.
DR OMA; SMENYYE; -.
DR Proteomes; UP000011712; Chromosome B2.
DR Bgee; ENSFCAG00000021984; Expressed in tip of external ear and 3 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0042017; F:interleukin-22 binding; IEA:Ensembl.
DR GO; GO:0042018; F:interleukin-22 receptor activity; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0042509; P:regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR015373; Interferon/interleukin_rcp_dom.
DR PANTHER; PTHR20859; INTERFERON/INTERLEUKIN RECEPTOR; 1.
DR PANTHER; PTHR20859:SF51; INTERLEUKIN-22 RECEPTOR SUBUNIT ALPHA-2; 1.
DR Pfam; PF09294; Interfer-bind; 1.
DR Pfam; PF01108; Tissue_fac; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..231
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016376471"
FT DOMAIN 8..114
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|Pfam:PF01108"
FT DOMAIN 126..230
FT /note="Interferon/interleukin receptor"
FT /evidence="ECO:0000259|Pfam:PF09294"
SQ SEQUENCE 231 AA; 26843 MW; 0B730BF5E198333D CRC64;
MTPKHCFLGF LISFLLTGVV ETQSAHESLM PQRVHFQSRN FHNILHWQPG RACTSNSSIY
FVQYKMYGQR QWKNKEDCWG ILESFCDLTN ETSDIQEPYY GRVRTISAGI RSGWTMTQRF
TPWWETKIDP PVMNITQVNG SLLVILHAPG LPYRDQKGKN VSIENFYELV YRVFIINNSI
GKEQKVYEGA HRVVEIGVLA PHTAYCVVAE MYQPMLDKRS RRSEEKCVEL P
//
