ID M3XEW5_FELCA Unreviewed; 1838 AA.
AC M3XEW5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 24-JAN-2024, entry version 65.
DE RecName: Full=Microtubule-associated protein {ECO:0000256|RuleBase:RU000686};
GN Name=MAP2 {ECO:0000313|Ensembl:ENSFCAP00000025174.2,
GN ECO:0000313|VGNC:VGNC:68153};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000025174.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000025174.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000025174.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000025174.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000025174.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000025174.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000025174.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|RuleBase:RU000686}.
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DR EMBL; AANG04002752; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_011283819.1; XM_011285517.2.
DR PaxDb; 9685-ENSFCAP00000019583; -.
DR Ensembl; ENSFCAT00000028216.4; ENSFCAP00000025174.2; ENSFCAG00000024249.4.
DR GeneID; 101095036; -.
DR KEGG; fca:101095036; -.
DR CTD; 4133; -.
DR VGNC; VGNC:68153; MAP2.
DR GeneTree; ENSGT00940000156597; -.
DR OrthoDB; 5406159at2759; -.
DR Proteomes; UP000011712; Chromosome C1.
DR Bgee; ENSFCAG00000024249; Expressed in brain and 10 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR InterPro; IPR027324; MAP2/MAP4/Tau.
DR InterPro; IPR013588; MAP2_projctn.
DR InterPro; IPR001084; MAP_tubulin-bd_rpt.
DR PANTHER; PTHR11501; MICROTUBULE-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR11501:SF15; MICROTUBULE-ASSOCIATED PROTEIN 2; 1.
DR Pfam; PF08377; MAP2_projctn; 1.
DR Pfam; PF00418; Tubulin-binding; 3.
DR PROSITE; PS00229; TAU_MAP_1; 1.
DR PROSITE; PS51491; TAU_MAP_2; 3.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|RuleBase:RU000686};
KW Cytoskeleton {ECO:0000256|RuleBase:RU000686};
KW Microtubule {ECO:0000256|RuleBase:RU000686};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 377..1516
FT /note="MAP2/Tau projection"
FT /evidence="ECO:0000259|Pfam:PF08377"
FT REGION 1..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 109..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 340..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 587..683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 768..788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 834..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 936..1041
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1088..1171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1210..1233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1308..1389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1414..1646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1791..1811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..80
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..191
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..381
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..418
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..466
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 480..494
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..653
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 666..683
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 936..989
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1111..1169
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1325..1341
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1360..1389
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1414..1490
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1511..1533
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1570..1587
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1594..1629
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1838 AA; 199462 MW; F313F02712BC86CA CRC64;
MADDRKDEAK APHWTSAQLT EASAHPHPPE IKDQGGAGEG LVRSANGFPY REDEEGAFGE
HGSQSTYSDT KENGINGELT SADRETAEEV SARIVQVVTA EAVAVLKGEQ EKEAEHKVQP
AALPLAAEET PNLPPSPPPS PASEQTVTVE EGLLPASKME FHDQQELTPS PAEPLDKKEK
ESEEQSKPGE DLKHAALASQ PETTKTSPDK KDTQGTEEEK APTALFGHAL GAGLEDMKQK
TEPSLVVPGI DLSAEPPAPK EQKDWFIEMP VEAKKDEWGL AAPISPGPLT PMKGKDVFED
IPKWEGKQFD SPMPSPFQAG SFTLPLDVIK NEIVAEASPF APALLQPDDK KSLEETSGPV
TAKDSSKAEE PHKDKPDKMA EAPASEAITL PKDAHIPTVE EYVPEKVLGE EKGAIKQESV
QKTEISTLSG QEATLTEKES QLKLEEKTTI SDKEAMPKES EPPKLTDEET GIIQPSVEHT
LSKEEQKGQD TTRDTLKQDS FPVSLEQTVT DSAMTSKTLE KVMTEPAAVS EQSATQDLFQ
EKVADKDHKV EGVGAETSAE LDMPFYEDKS GMSKYFETSA LKEEVTKSIQ PGSDYYELSD
TRESAQEPFD TVSPAYKNGD KGLQAGKEPQ PSAPAQEAGY STLAQSYPSE VPEEPSSPQE
RMFTIDPKVY GEKRDLHSKN KDDLTLSRSL GLGGRSAIEQ RSMSINLPMS CLDSIALGFN
FGRGHDLSPL ASDILTNTSG SMDEGDDYLP ATTPALEKAP CFPVESKEEE EQIEGEKATG
EENAQVETSC ESPFLAKDYY KNGTVMAPDL PEMLDLAGTR SRLASVSADA EVARRKSVPS
ETVVEESSAG LPPVTDENHV VVKTDSQLED LGYCVFNKYT VPLPSPVQDS ENLSGESGSF
YEGTDDKMRR DLATDLSLIE VKLAAAGRVK DEFGAEKEVS PHIPGDKSVL GREFDQERKA
NDKLDTVLEK SEEHADAKEH AKATEEASDK VETFGLGVTY EHPSTKELPV SKDTSPPAAE
KAETGLSSVP EIAEVEPSKK AEPELDVIAQ KADQGQLDVK ISDFGQMAAG LTIDAGKATE
LQLEATQDLT PSSAVPQEGD MFLSVDPGHM KEGTKTSETE IKEKVAKPDL VHQEAVDKEE
SYESSGEHES LTMESLKADE GKKETSPESS LIQDEIAIKL SVEIPCAPAV SEADLAPDER
ADVQMEFIQQ PKEESKEAPY ISVTPSDVTE PLPKAIGAEP AEVQSEEEEI EARGEYDKLL
FRSDTLQITD LGIAGVREEF VETCPGEHKG VIESVVTIED DFITVVQTTT EEGESGSHSV
RFAALEQPEV ERRPSPHAEE ELEVEEAAEA QAEPKDGSPE APASPEREEV ALSEYKTETY
DDYKDETTID DSIMDADSLW VDTQDDDRSI MTEQLETIPK EEKAEKEARR PSLEKHRKEK
PFKTGRGRIS TPERKIAKKE PSTVSRDEVR RKKAVYKKAE LAKKTEVQAH SPSRKFILKP
AIKYTRPTHL SCVKRKTTAT GGETTQASSV FKQAKDKVSD GVTKSPEKRS SLPRPSSILP
PRRGVSGDRE ENSFSLNSSI SSSARRTTRS EPIRRAGKSG TSTPTTPGST AITPGTPPSY
SSRTPGTPGT PSYPRTPHTP GTPKSAILVP SEKKVAIIRT PPKSPATPKQ LRLINQPLPD
LKNVKSKIGS TDNIKYQPKG GQVQIVTKKI DLSHVTSKCG SLKNIRHRPG GGRVKIESVK
LDFKEKAQAK VGSLDNAHHV PGGGNVKIDS QKLNFREHAK ARVDHGAEII TQSPGRSSVA
SPRRLSNVSS SGSINLLESP QLATLAEDVT AALAKQGL
//
