ID M3XG95_FELCA Unreviewed; 1058 AA.
AC M3XG95;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 3.
DT 24-JAN-2024, entry version 61.
DE SubName: Full=RIMS binding protein 2 {ECO:0000313|Ensembl:ENSFCAP00000025656.3};
GN Name=RIMBP2 {ECO:0000313|Ensembl:ENSFCAP00000025656.3,
GN ECO:0000313|VGNC:VGNC:64630};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000025656.3, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000025656.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000025656.3,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000025656.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000025656.3,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000025656.3}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000025656.3};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RIMBP family.
CC {ECO:0000256|ARBA:ARBA00010749}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AANG04002765; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3XG95; -.
DR Ensembl; ENSFCAT00000022065.3; ENSFCAP00000025656.3; ENSFCAG00000031758.4.
DR VGNC; VGNC:64630; RIMBP2.
DR eggNOG; KOG3632; Eukaryota.
DR GeneTree; ENSGT00950000183203; -.
DR HOGENOM; CLU_001979_0_0_1; -.
DR Proteomes; UP000011712; Chromosome D3.
DR Bgee; ENSFCAG00000031758; Expressed in prefrontal cortex and 5 other cell types or tissues.
DR CDD; cd00063; FN3; 3.
DR CDD; cd12014; SH3_RIM-BP_1; 1.
DR CDD; cd12012; SH3_RIM-BP_2; 1.
DR CDD; cd12013; SH3_RIM-BP_3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 2.30.30.40; SH3 Domains; 3.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR035753; RIM-BP_SH3_2.
DR InterPro; IPR035755; RIM-BP_SH3_3.
DR InterPro; IPR040325; RIMBP1/2/3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR14234; RIM BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR14234:SF18; RIMS-BINDING PROTEIN 2; 1.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF14604; SH3_9; 2.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00326; SH3; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF50044; SH3-domain; 3.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50002; SH3; 3.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 167..234
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 489..590
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 855..923
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 958..1025
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 118..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 584..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 631..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 734..823
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1..57
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 145..161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 584..598
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 648..671
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 737..757
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1058 AA; 115794 MW; 068A338EF2A07FCD CRC64;
MREAAERRQQ LELEHEQALA VLHAKQQEID LLQKSKVREL EEKCRTQSEQ FSLLSQDLER
LRQHAGKIDL LGVSPGVSVD VPAPGKPFPQ FMNGLSPSIG KGQESTVGSR TVTGDYIRPL
PLPGDKPEPL PIKPTFLSRS ASPRCRFESD MDNERSSSTS KQQRHSGKVH LCVARYSYNP
FDGPNENPEA ELPLTAGKYL YVYGDMDEDG FYEGELLDGQ RGLVPSNFVD FVQDNESRPA
STLGNEQDQN LINRSGIGSE GENILDLHAP TPIDAGVADG GAETLGVSVD DVGEDIVPYP
RKITLIKQLA RSVIVAWEPP AVPPGWGTVS SYSVLVDQEP RVSLTLGSRT KALIEKLDTA
ACTYRISVQC ATSRGHSDEL RCTLLVGKDV AVAPSQLRVD NITQISAQLS WLPANSNYSH
VIFLNEEELD VVRAASYTYQ FFNLRPNVAY KVKVLARPHQ MPWQLPLEQR EKKEAFVEFS
TLPAGPPAPP QDVTVHAGPT PATVQVSWKP PALTTAGLSN GANVTGYGVY AKGQRVAEVI
SPVADSTAVE LVRLRSLEAK AVTVRTLSAQ GESVDSAFAA IPPDLLVPPT PHPRTAPTPK
PLASAGAPDT KEEHPGPHIM VDEAWEQSRA PAPAHGHMLE PPSMQGSGPG RRSPSPSRIL
PQPQGTPVST SVAKAMAREA AQRVAESSRL EKRSIFLERG GSLYVNSDEE DGYGSPDVKR
RGASVDDFLR GSELGKQPHC CHGDEYHTES SRGSDLSDIM EEDEEELCSE TQLEDGGRRR
PGGTSHNALK ILGNPVSAGR ADRADHAGRR FPHGSAGPQR SRPVMVPSID EYSERDHLSP
DFYEESETDP GTEELPARIF VALFDYDPLT MSPNPDAAEE ELPFKEGQII KVYGDKDADG
FYRGETCARL GLIPCNMVSE IQADDEDMMD QLLRQGFLPL NTPVEKIERS RRGGRHPGAT
RRVVALYDYD PRESSPNIDV EAELTFCTGD IITVFGEIDE DGFYYGELNG QKGLVPSNFL
EEVPDDVEVY LSDAPCHYSR DAPPRSKAKR KKSVHFTP
//
