ID M3XJB6_LATCH Unreviewed; 843 AA.
AC M3XJB6;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=dynamin GTPase {ECO:0000256|ARBA:ARBA00011980};
DE EC=3.6.5.5 {ECO:0000256|ARBA:ARBA00011980};
GN Name=DNM1 {ECO:0000313|Ensembl:ENSLACP00000022822.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000022822.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000022822.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. Dynamin/Fzo/YdjA family. {ECO:0000256|RuleBase:RU003932}.
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DR EMBL; AFYH01038057; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01038058; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01038059; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01038060; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01038061; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01038062; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01038063; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01038064; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01038065; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01038066; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_014341675.1; XM_014486189.1.
DR AlphaFoldDB; M3XJB6; -.
DR Ensembl; ENSLACT00000025224.1; ENSLACP00000022822.1; ENSLACG00000017341.2.
DR GeneID; 102353009; -.
DR CTD; 100307098; -.
DR GeneTree; ENSGT00940000155214; -.
DR HOGENOM; CLU_008964_1_1_1; -.
DR OrthoDB; 1052588at2759; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000017341; Expressed in pelvic fin and 4 other cell types or tissues.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd08771; DLP_1; 1.
DR CDD; cd01256; PH_dynamin; 1.
DR Gene3D; 1.20.120.1240; Dynamin, middle domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR022812; Dynamin.
DR InterPro; IPR001401; Dynamin_GTPase.
DR InterPro; IPR019762; Dynamin_GTPase_CS.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR000375; Dynamin_stalk.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR003130; GED.
DR InterPro; IPR020850; GED_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR11566; DYNAMIN; 1.
DR PANTHER; PTHR11566:SF32; DYNAMIN-1; 1.
DR Pfam; PF01031; Dynamin_M; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF02212; GED; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00195; DYNAMIN.
DR SMART; SM00053; DYNc; 1.
DR SMART; SM00302; GED; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS00410; G_DYNAMIN_1; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
DR PROSITE; PS51388; GED; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW GTP-binding {ECO:0000256|RuleBase:RU003932};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU003932};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 28..294
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT DOMAIN 515..621
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 651..742
FT /note="GED"
FT /evidence="ECO:0000259|PROSITE:PS51388"
FT REGION 759..843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 759..773
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 774..832
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 843 AA; 95297 MW; 15181E9B0B805E17 CRC64;
MGNRGMEELI PLVNKLQDAF SAIGQNANLD LPQIAVVGGQ SAGKSSVLEN FVGRDFLPRG
SGIVTRRPLV LQLINSVTEH AEFLHCKGKK FTDFDEVRQE IEAETDRITG SNKGISSIPI
NLRVYSPNVL NLTLIDLPGM TKVPVGDQPA DIEFQIREML MQFVTKENCL VLAVSPANTD
LANSDALKIA KEVDPQGLRT IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK
DIDGKKDIQA ALAAERKFFL SHPSYRHLAD RMGTPYLQKV LNQQLTNHIR DTLPALRNKL
QSQLLSIEKE VEEYKNFRPD DPARKTKALL QMVQQFAVDF EKRIEGSGDQ IDTYELSGGA
RINRIFHERF PFELVKMEFD EKELRREISY AIKNIHGIRT GLFTPDMAFE TIVKKQVKKI
KEPCLKCVDM VISELINTVR QCTKKLGQYP HLREEMERIV TTYIREREGR TKEQVMLLID
IELSYMNTNH EDFIGFANAQ QRSNQMSKKK ASGNQVIRKG WLTINNISIM KGGAKEYWFV
LTAENLSWYK DDEEKEKKYM LPVDNLKLRD VEKGFMSSKH IFALFNTEQR NVYKDYRQLE
LACETQEEVD SWKASFLRAG VYPERVGQSE TEENGSDSFM HSMDPQLERQ VETIRNLVDS
YMGIVNKTIR DLMPKTIMHL MINNTKDFIH SELLANLYSC GDQNTLMEES AEQAQRRDEM
LRMYHALREA LHIIGDINTT TISTPLPPPV DDSWLQVQNV QSGRRSPTSS PTPQRRAPAV
PPARPGSRGP APGPPPPGAS QGSAPPVPSR PLSASDPFGP PPQVPSRPNR APPGVPRITI
SDP
//
