ID M3XKT0_LATCH Unreviewed; 367 AA.
AC M3XKT0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=MAM and LDL receptor class A domain containing 1 {ECO:0000313|Ensembl:ENSLACP00000023336.1};
GN Name=MALRD1 {ECO:0000313|Ensembl:ENSLACP00000023336.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000023336.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000023336.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AFYH01074294; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01074295; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01074296; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01074297; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01074298; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01074299; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01074300; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01074301; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01074302; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01074303; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3XKT0; -.
DR Ensembl; ENSLACT00000026530.1; ENSLACP00000023336.1; ENSLACG00000010137.2.
DR GeneTree; ENSGT00940000158809; -.
DR HOGENOM; CLU_627842_0_0_1; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 3.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 3.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR000998; MAM_dom.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR22722:SF14; MEGALIN, ISOFORM A; 1.
DR Pfam; PF00057; Ldl_recept_a; 3.
DR Pfam; PF00629; MAM; 1.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00192; LDLa; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 3.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 3.
DR PROSITE; PS50060; MAM_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 257..280
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..71
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 206..240
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 347..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 101..116
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 130..142
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 137..155
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 149..164
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 230..239
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 367 AA; 39842 MW; 250D5DE575F8FF16 CRC64;
MGTLKVYTVG ESGINLLMWS ISGNKGNQWI YTNVIISNNS PFHVAFEAEV GGDRQTDIAL
DDISFTPECT IGGPIPQPTT CRTDFFQCLH VHQCIPLLWK CDGEEDCKDG TDEFNCPTRS
PGTLPPQGSC SKTEFQCSSE ECIPSLLRCD GVSDCPRAED EYRCPTAACF NGSLLCGSTG
KCIPVSKRCD GTVDCSDFNP DESSCSECPT GYCKNGGSCV IENRIPLCQC TQEWRGNRCH
FMVKPTLSPT VGSRSGAFWV GVSFGLALIV IGLIAVLCFL SKKKLPTKIS TEIKYGTMDN
PVYGDQSVDG TSEFVMNDVF PGVNISVFPW RKQQEGSSHT ANSVSFANPL YESTPGNTEE
TSKSSEV
//
