ID M3XLU3_MUSPF Unreviewed; 309 AA.
AC M3XLU3;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=GRB2 related adaptor protein {ECO:0000313|Ensembl:ENSMPUP00000000043.1};
DE SubName: Full=GRB2-related adapter protein {ECO:0000313|RefSeq:XP_004776606.1};
GN Name=LOC101673383 {ECO:0000313|RefSeq:XP_004776606.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000000043.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000000043.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004776606.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004776606.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AEYP01089343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01089344; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004776606.1; XM_004776549.3.
DR STRING; 9669.ENSMPUP00000000043; -.
DR Ensembl; ENSMPUT00000000043.1; ENSMPUP00000000043.1; ENSMPUG00000000043.1.
DR GeneID; 101673383; -.
DR KEGG; mpuf:101673383; -.
DR CTD; 10750; -.
DR eggNOG; KOG3601; Eukaryota.
DR GeneTree; ENSGT00940000156254; -.
DR HOGENOM; CLU_073617_1_0_1; -.
DR OMA; NKGDMLK; -.
DR OrthoDB; 25371at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR CDD; cd09941; SH2_Grb2_like; 1.
DR CDD; cd11948; SH3_GRAP_N; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR035645; GRAP_N_SH3.
DR InterPro; IPR043539; Grb2-like.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46037:SF2; GRB2-RELATED ADAPTER PROTEIN; 1.
DR PANTHER; PTHR46037; PROTEIN ENHANCER OF SEVENLESS 2B; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF00018; SH3_1; 2.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 90..150
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 152..251
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 250..309
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 45..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..71
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 309 AA; 34658 MW; 61AF43A8DA90EE6D CRC64;
MGGRGDPLPG LPGESPRVIP GLWGSKVEAQ PLTGSPCSVT CQLPVSPPSG AASKAQHTLK
TKEDGSSGPR LQRKQEELTQ LGAQLLGPGD SGMESVALYS FQATESDELA FNKGDTLKIL
NMEDDQNWYK AELRGAEGFI PKNYIRVKPH PWYSGRISRQ LAEEILMKRN HLGAFLIRES
ESSPGEFSVS VNYGDQVQHF KVLREASGKY FLWEEKFNSL NELVDFYRTT TIAKQRQVFL
RDEETPLKAP QACFAQAQFD FSAQDSSQLS FHRGDIIEVL EHLDPHWWRG RLCGRIGFFP
RSYVQPVQL
//
