ID M3XN34_MUSPF Unreviewed; 2178 AA.
AC M3XN34;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 61.
DE SubName: Full=Bromodomain adjacent to zinc finger domain 2B {ECO:0000313|Ensembl:ENSMPUP00000000484.1};
GN Name=BAZ2B {ECO:0000313|Ensembl:ENSMPUP00000000484.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000000484.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000000484.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WAL family. {ECO:0000256|ARBA:ARBA00007444}.
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DR EMBL; AEYP01014671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01014672; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01014673; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01014674; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01014675; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01014676; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01014677; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01014678; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01014679; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01014680; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9669.ENSMPUP00000000484; -.
DR Ensembl; ENSMPUT00000000495.1; ENSMPUP00000000484.1; ENSMPUG00000000490.1.
DR eggNOG; KOG1245; Eukaryota.
DR GeneTree; ENSGT00940000155359; -.
DR HOGENOM; CLU_000899_0_0_1; -.
DR InParanoid; M3XN34; -.
DR OMA; XASGQTL; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd05503; Bromo_BAZ2A_B_like; 1.
DR CDD; cd01397; HAT_MBD; 1.
DR CDD; cd15630; PHD_BAZ2B; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR037374; BAZ2A/B_Bromo.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR028942; WHIM1_dom.
DR InterPro; IPR028941; WHIM2_dom.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45915:SF1; BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2B; 1.
DR PANTHER; PTHR45915; TRANSCRIPTION INTERMEDIARY FACTOR; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF02791; DDT; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF15612; WHIM1; 1.
DR Pfam; PF15613; WSD; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00571; DDT; 1.
DR SMART; SM00391; MBD; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 3: Inferred from homology;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 738..809
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 1095..1160
FT /note="DDT"
FT /evidence="ECO:0000259|PROSITE:PS50827"
FT DOMAIN 1941..1991
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2087..2157
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 139..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 411..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 524..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 576..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 712..740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 839..874
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1029..1051
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1273..1349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1442..1468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1511..1550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1591..1615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2008..2070
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..241
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..286
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..323
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..347
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 603..659
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 669..691
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 712..732
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 839..869
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1307..1328
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1448..1464
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1511..1542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2038..2053
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2178 AA; 241828 MW; DD1C1307B4FDA869 CRC64;
MESGERLPSS TASTTTPSSS LPSVASSVSK GGLSTGAASL SSTINPCGHL FRAAGDQPFN
LSTVSSAFPM VSHPVFGLHS ASSGHSEFGG LGTLGTPTAL AAHPQLASFP GAEWWRTADV
HSRTGATFFP PLLGIPPLFA PPAQNHDSSS FHSRTSGKSN RNGPEKGVNG SINGNSTSSV
SGINTPVLST TASSSVGQTK SLSSGGGNRK CNQEQNKNQP LDARADKIKD KKPRKKTMES
SSNSDSDSGT SSDTSSEGIS SSDSDDLEED EEEDQSIEES EDDDSDSESE AQHKSNNQVL
LHGISDPKAD GQKATEKAQE KRIHQPLPLV SESQTHSSFQ SQQKQPQVLS QQLPFIFQSS
QAKEESVNKH TSVIQSTGLV SNVKPLSLVN QAKKETYMKL IVPSPDVLKA GNKNTSEESS
PLTSEMRSKR EQYKQTFPVQ LKKQESSKSL KKVIAALSNT KATSSSPAHP KQTVENNHPN
PFLTNALLGN HQPNGVIQSV IQEAPLALTT KTKMQSKINE NIATASSSPF SSPVNLSTTG
RRTAGNQTTV IPSASPIVHP QGKEKVVSNN VNTVKTQLHP HPAKSLVEQF RGTDSDIPSS
KDSEDSNEDE EEDDEEEDEE DDEDDESDDS QSESDSNSES DTEGSEEDDD DDKDQDESDS
DTEGEKTSMK LNKTTSSVKS PSISLTAHST PRNLHIAKAP GSAPAALCSE SQSPAFLGTP
SSTLTSSPHS GTSKRRRVTD ERELRIPLEY GWQRETRIRN FGGRLQGEVA YYAPCGKKLR
QYPEVIKYLS RNGIMDISRD NFSFSAKIRV GDFYEARDGP QGMQWCLLKE EDVIPRIRAM
EGRRGRPPNP DRQRAREESR MRRRKGRPPN VGSAEFLDNT DAKLLRKLQA QEIARQAAQI
KLLRKLQKQE QARVAKEAKK QQAIMAAEEK RKQKEQIKIM KQQEKIKRIQ QIRMEKELRA
QQILEAKKKK KEEAANAKLL EAEKRIKEKE MRRQQAVLLK HQELERHRLD MERERRRQHM
MLMKAMEARK KAEEKERLKQ EKRDEKRLNK ERKLEQRRLE LEMAKELKKP NEDMCLADQK
PLPELPRIPG LVLSGSTFSD CLMVVQFLRN FGKVLGFDVN IDVPNLSVLQ EGLLNIGDSM
GEVQDLLVRL LSAAVCDPGL ITGYKAKTAL GEHLLNVGVN RDNVSEILQI FMEAHCGQTE
LTESLKTKAF QAHTPEQKAS VLAFLINELA CSKSVVSEID KNIDYMSNLR RDKWVVEGKL
RKLRIIHAKK TGKRDTSGGI DLGEEQHPLG TPTPGRKRRR KGGDSDFDDD DDDDSEDQAD
EDDEDEEDKE DKKGKKTDIC EDEDEGDQAA SVEELEKQIE KLSKQQSQYR RKLFDASHSL
RSMMFGQDRY RRRYWILPQC GGIFVEGMES GEGLDEIAKE REKLKKAESI QIKEEIFETS
EDTLNCSNPD HCEQKEDPKE KDNTNLFLQK PGSFSKLSKL LEVAKMPPES DVMTPKPNNS
ANGCTLSYQN SGKHSLGSVQ STATQSNMEK TDANNLFSPG SSGPGKFYSP LPNDQLLKTL
TEKNRQWFSL LPRTPCDDTS LTHADIPAAS VVTPQSQPPS TSPSPAPAPL LGSSSAQNPV
GLNPFAVSPL QMKSGVSMMG LQFCGWPTGV LASNIPFTSP VPSLGSGLGL SEGNGNSFLT
PNVASSKSES PVPQIEKVSS TQPAAVEVAK PVDFPSPKPI PEEMQFGWWR IIDPEDLKAL
LKVLHLRGIR EKALQKQIQK HLDYITQACI KNKDVAIIEL NENEENQVTR DIVENWSVED
QAMEMDLSIL QQVEDLERRV ASASLQVKGW MCPEPASERE DLVYFEHKSF SKLCKEHDGE
FTGEEESSAH ALERKSDNPL DIAVTRLADL ERNIERRIEE DIAPGLRVWR RALSEARSAA
QVALCIQQLQ KSIAWEKSIM KVYCQICRKG DNEELLLLCD GCDKGCHTYC HRPKITTIPD
GDWFCPACIA KASGQTLKIK KLHVKGKKTN ESKKGKKVTL TGDTEDEDSA STNSSLKRGS
KDLKKRKMEE NTSVNLSKQE SSTSVKKPKR DDSKDLALCS MILTEMETHE DAWPFLLPVN
LKLVPGYKKV IKKPMDFSTI REKLSSGQYP NLETFAVDVR LVFDNCETFN EDDSDIGRAG
HSMRKYFEKK WTDIFKVS
//
