ID M3XPL8_MUSPF Unreviewed; 401 AA.
AC M3XPL8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Tumor necrosis factor receptor superfamily member 11B {ECO:0000256|PIRNR:PIRNR038065};
DE AltName: Full=Osteoprotegerin {ECO:0000256|PIRNR:PIRNR038065};
GN Name=TNFRSF11B {ECO:0000313|Ensembl:ENSMPUP00000001018.1,
GN ECO:0000313|RefSeq:XP_004743539.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000001018.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000001018.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004743539.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004743539.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Acts as decoy receptor for TNFSF11/RANKL and thereby
CC neutralizes its function in osteoclastogenesis.
CC {ECO:0000256|PIRNR:PIRNR038065}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|PIRNR:PIRNR038065}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR EMBL; AEYP01013553; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004743539.1; XM_004743482.3.
DR STRING; 9669.ENSMPUP00000001018; -.
DR Ensembl; ENSMPUT00000001039.1; ENSMPUP00000001018.1; ENSMPUG00000001026.1.
DR GeneID; 101693152; -.
DR KEGG; mpuf:101693152; -.
DR CTD; 4982; -.
DR eggNOG; ENOG502QVRT; Eukaryota.
DR GeneTree; ENSGT00940000155167; -.
DR HOGENOM; CLU_057708_0_0_1; -.
DR OMA; CENGVQR; -.
DR OrthoDB; 5348767at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0031012; C:extracellular matrix; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl.
DR GO; GO:0042489; P:negative regulation of odontogenesis of dentin-containing tooth; IEA:Ensembl.
DR GO; GO:0045671; P:negative regulation of osteoclast differentiation; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01670; Death; 1.
DR CDD; cd00185; TNFRSF; 1.
DR CDD; cd10581; TNFRSF11B; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR022323; TNFR_11.
DR InterPro; IPR017371; TNFR_11B.
DR PANTHER; PTHR23097; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER; 1.
DR PANTHER; PTHR23097:SF90; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 11B; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF00020; TNFR_c6; 4.
DR PIRSF; PIRSF038065; TNFR_11B; 1.
DR PRINTS; PR01961; TNFACTORR11.
DR PRINTS; PR01975; TNFACTORR11B.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00208; TNFR; 4.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR SUPFAM; SSF57586; TNF receptor-like; 2.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703, ECO:0000256|PIRNR:PIRNR038065};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR038065-2};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Receptor {ECO:0000313|RefSeq:XP_004743539.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..401
FT /note="Tumor necrosis factor receptor superfamily member
FT 11B"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041198371"
FT REPEAT 64..105
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 64..105
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT DOMAIN 323..365
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT SITE 400
FT /note="Involved in dimerization"
FT /evidence="ECO:0000256|PIRSR:PIRSR038065-1"
FT DISULFID 41..54
FT /evidence="ECO:0000256|PIRSR:PIRSR038065-2"
FT DISULFID 44..62
FT /evidence="ECO:0000256|PIRSR:PIRSR038065-2"
FT DISULFID 65..80
FT /evidence="ECO:0000256|PIRSR:PIRSR038065-2,
FT ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 83..97
FT /evidence="ECO:0000256|PIRSR:PIRSR038065-2"
FT DISULFID 87..105
FT /evidence="ECO:0000256|PIRSR:PIRSR038065-2,
FT ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 107..118
FT /evidence="ECO:0000256|PIRSR:PIRSR038065-2"
FT DISULFID 124..142
FT /evidence="ECO:0000256|PIRSR:PIRSR038065-2"
FT DISULFID 145..160
FT /evidence="ECO:0000256|PIRSR:PIRSR038065-2"
FT DISULFID 166..185
FT /evidence="ECO:0000256|PIRSR:PIRSR038065-2"
SQ SEQUENCE 401 AA; 46244 MW; 18E068622D9E3157 CRC64;
MNQLLCCALV FLDISIKWTT QETFPPKYLH YDPETSRQLM CDKCPPGTSL KQHCTARRKT
VCAPCPNHYY TDRWHTSDEC LYCTPVCKEL QYIKQECNRT HNRVCECEEG RYLEVEFCLK
HRSCPPGFGV LHAGTPERNT VCRRCPDGFF SNETSSKAPC RKHTDCSAFG LLLIQKGNAT
HDNVCSANSE PTQKCGIDVT LCEEAFFRFA VPTKFTPNWL SILVDNLPGT RVNAESVEKI
KRQHSSQEQT FQLLKLWKHQ NKDQDMVKKI FQDIDLCENS VQRHIGHANL TFEQLRSLME
SLPGKKVPAE DIEKTLKACK SSEQILKLLS LWRIKNGDQD TLKALMHALK HLKTYHFPKA
VTQSLKKTIR FLHSFTMYRL YQKLFLEMIG NQVQSVKISC L
//
