ID M3XQI6_MUSPF Unreviewed; 124 AA.
AC M3XQI6;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=SH2 domain-containing protein 1A {ECO:0000256|ARBA:ARBA00013980, ECO:0000256|PIRNR:PIRNR037828};
GN Name=SH2D1A {ECO:0000313|Ensembl:ENSMPUP00000001336.1,
GN ECO:0000313|RefSeq:XP_004762078.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000001336.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000001336.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004762078.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004762078.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Cytoplasmic adapter regulating receptors of the signaling
CC lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244,
CC LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with
CC SH2D1B/EAT-2. {ECO:0000256|PIRNR:PIRNR037828}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|PIRNR:PIRNR037828}.
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DR EMBL; AEYP01054807; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01054808; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004762078.1; XM_004762021.3.
DR STRING; 9669.ENSMPUP00000001336; -.
DR Ensembl; ENSMPUT00000001364.1; ENSMPUP00000001336.1; ENSMPUG00000001348.1.
DR GeneID; 101693872; -.
DR KEGG; mpuf:101693872; -.
DR CTD; 4068; -.
DR eggNOG; KOG0565; Eukaryota.
DR GeneTree; ENSGT00940000155920; -.
DR HOGENOM; CLU_125532_1_0_1; -.
DR OMA; CVLCNGY; -.
DR OrthoDB; 3891423at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0007267; P:cell-cell signaling; IEA:InterPro.
DR GO; GO:0006968; P:cellular defense response; IEA:UniProtKB-UniRule.
DR GO; GO:0006959; P:humoral immune response; IEA:Ensembl.
DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IEA:Ensembl.
DR GO; GO:0050860; P:negative regulation of T cell receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IEA:Ensembl.
DR CDD; cd10400; SH2_SAP1a; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR017289; SH2_prot_1A.
DR InterPro; IPR035876; SH2D1A_SH2.
DR PANTHER; PTHR46051:SF1; IPPC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46051; SH2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00017; SH2; 1.
DR PIRSF; PIRSF037828; SH2_p1A; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130,
KW ECO:0000256|PIRNR:PIRNR037828}; Cytoplasm {ECO:0000256|PIRNR:PIRNR037828};
KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|PIRNR:PIRNR037828};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW ECO:0000256|PIRNR:PIRNR037828};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 6..102
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
SQ SEQUENCE 124 AA; 13834 MW; 683D62554616F74E CRC64;
MDAVAVYHGK ISRETGEKLL LATGLDGSYL LRDSETVPGV YCLCVLYQGY IYTYRVSQTE
TGSWSAETAP GVHKRFFRKI KNLISAFQKP DQGIVIPLQY PVEKKCSQGA TGRREDPDVF
LKAP
//
