ID M3XQV0_MUSPF Unreviewed; 377 AA.
AC M3XQV0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein {ECO:0000259|Pfam:PF01073};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000001450.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000001450.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219, ECO:0000256|RuleBase:RU004475}.
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DR EMBL; AEYP01076542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3XQV0; -.
DR STRING; 9669.ENSMPUP00000001450; -.
DR Ensembl; ENSMPUT00000001480.1; ENSMPUP00000001450.1; ENSMPUG00000001463.1.
DR eggNOG; KOG1430; Eukaryota.
DR GeneTree; ENSGT00940000155444; -.
DR HOGENOM; CLU_007383_6_3_1; -.
DR InParanoid; M3XQV0; -.
DR OMA; PKYSWEE; -.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd09811; 3b-HSD_HSDB1_like_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU004475}.
FT DOMAIN 11..291
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 377 AA; 43000 MW; D19D107CB695BF88 CRC64;
PYLTMAGWSC LVTGAGGFLG QRIVRLLAEE KELQEIRALD KVFRPEQREE FSKLQSKTNL
MMVEGDILDE QCLKRACQGI SVVIHTASVI DVMNVLHRET IMNVNLKGTQ LLLEACAQAS
VPIFIYTSTI EVAGPNSYRE IIQNGHEEEH LESRWSAPYP YSKKLAEKAV LAANGWALKN
GGTLHTCALR PMYIYGEGSA FLYDCIYKAL RNDGVLTHQS KFSIANPVYV GNVAWAHILA
LRALRDPKKA PSVQGQFYYI SDDTPHQSYD DFNYTLSKEW GFSLDSRMSL PICLKYWLAF
LLEIVSFLLR PIYKYPPPFN RHTVTLLNSV FTFSYKKAQR DLGYKPLFSW EEAKQKTVEW
IGSLVKQHRE TLKTKTH
//
