ID M3XRB9_MUSPF Unreviewed; 1052 AA.
AC M3XRB9;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Ubiquitin like modifier activating enzyme 6 {ECO:0000313|Ensembl:ENSMPUP00000001619.1};
DE SubName: Full=Ubiquitin-like modifier-activating enzyme 6 isoform X1 {ECO:0000313|RefSeq:XP_004764362.1};
GN Name=UBA6 {ECO:0000313|Ensembl:ENSMPUP00000001619.1,
GN ECO:0000313|RefSeq:XP_004764362.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000001619.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000001619.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004764362.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004764362.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family.
CC {ECO:0000256|ARBA:ARBA00005673}.
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DR EMBL; AEYP01060960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01060961; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01060962; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01060963; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01060964; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004764362.1; XM_004764305.3.
DR STRING; 9669.ENSMPUP00000001619; -.
DR Ensembl; ENSMPUT00000001653.1; ENSMPUP00000001619.1; ENSMPUG00000001636.1.
DR GeneID; 101692569; -.
DR KEGG; mpuf:101692569; -.
DR CTD; 55236; -.
DR eggNOG; KOG2012; Eukaryota.
DR GeneTree; ENSGT00940000158826; -.
DR HOGENOM; CLU_002556_0_0_1; -.
DR OMA; WSHCVEL; -.
DR OrthoDB; 20494at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0019780; F:FAT10 activating enzyme activity; IEA:Ensembl.
DR GO; GO:0004839; F:ubiquitin activating enzyme activity; IEA:Ensembl.
DR GO; GO:0021764; P:amygdala development; IEA:Ensembl.
DR GO; GO:0060996; P:dendritic spine development; IEA:Ensembl.
DR GO; GO:0021766; P:hippocampus development; IEA:Ensembl.
DR GO; GO:0007612; P:learning; IEA:Ensembl.
DR GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR CDD; cd01491; Ube1_repeat1; 1.
DR CDD; cd01490; Ube1_repeat2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 2.40.30.180; Ubiquitin-activating enzyme E1, FCCH domain; 1.
DR Gene3D; 3.50.50.80; Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1; 1.
DR Gene3D; 3.40.50.12550; Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2; 1.
DR Gene3D; 1.10.10.2660; Ubiquitin-activating enzyme E1, SCCH domain; 1.
DR Gene3D; 3.10.290.60; Ubiquitin-activating enzyme E1, UFD domain; 1.
DR InterPro; IPR032420; E1_4HB.
DR InterPro; IPR032418; E1_FCCH.
DR InterPro; IPR042302; E1_FCCH_sf.
DR InterPro; IPR045886; ThiF/MoeB/HesA.
DR InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR InterPro; IPR018965; Ub-activating_enz_E1_C.
DR InterPro; IPR042449; Ub-E1_IAD_1.
DR InterPro; IPR038252; UBA_E1_C_sf.
DR InterPro; IPR019572; UBA_E1_SCCH.
DR InterPro; IPR042063; Ubi_acti_E1_SCCH.
DR InterPro; IPR035985; Ubiquitin-activating_enz.
DR InterPro; IPR018075; UBQ-activ_enz_E1.
DR InterPro; IPR000011; UBQ/SUMO-activ_enz_E1-like.
DR NCBIfam; TIGR01408; Ube1; 1.
DR PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR PANTHER; PTHR10953:SF186; UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 6; 1.
DR Pfam; PF16191; E1_4HB; 1.
DR Pfam; PF16190; E1_FCCH; 1.
DR Pfam; PF09358; E1_UFD; 1.
DR Pfam; PF00899; ThiF; 2.
DR Pfam; PF10585; UBA_E1_SCCH; 1.
DR PRINTS; PR01849; UBIQUITINACT.
DR SMART; SM00985; UBA_e1_C; 1.
DR SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 2.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715}.
FT DOMAIN 921..1043
FT /note="Ubiquitin-activating enzyme E1 C-terminal"
FT /evidence="ECO:0000259|SMART:SM00985"
SQ SEQUENCE 1052 AA; 117949 MW; 88570733388FEADE CRC64;
MEASEPVAAP QREEASCSSW GAVSTNTNLP IISAESVEID DALYSRQRYV LGDTAMQKMA
KSHVFLSGMG GLGLEIAKNL VLAGIKALTI HDTEKCQMWD LGTNFFLCED DVVNMRNRAE
AVLHHIAELN PYVHVTSSSV PLDETTDLSF LDKYQCVVLT EIKLPLQKKI NNFCHSHCPP
IKFISADMHG IWSRLFCDFG DEFEVSDTTG EEPKEIFISN ITQANPGIVT CLENHPHKLE
TGQFVTFREV NGMMGLNGST QQITVVSPFS FSIGDTTDLE PYLHGGIAVQ IKTSKTFCFE
PLETQIKHPK CLIADFSNPE APLEIHTAML ALDQFQESYN RKPNIGCQKD SEELLKLATS
ISETLEEKPE VNADIVHWLS WTAQGFLPPL AAAVGGVASQ EVLKAVTGKF SPLCQWLYIE
AADIVETLGK PEREQFLPRG DRYDALRACI GDTLCQKLQK LNIFLVGCGA IGCEMLKNFA
LLGVGTGKEK GMVTVTDPDL IEKSNLNRQF LFRPHHIQKP KSYTAADATL KINPQLKIDA
HLNKVCPATE AIYNDEFYTK QDIIITALDN VEARRYVDSR CLANLRPLLD SGTMGTKGHT
EVIVPHLTES YNSHRDPPEE EIPFCTLKSF PAAIEHTIQW ARDKFESSFS HKPSLFNKFW
QTYPSAEEVL QKLQTGHSLE GCFQVIKLLS RRPRNWSQCV ELARLKFEKY FNHKALQLLH
CFPLDTRLKD GSLFWQSPKR PPSPIKFDLN EPLHFSFLLN AAKLYAAVYC IPLTEEDLSA
DALLNILSEV KIQEFRPSNK VVQTDETARK PEHVPISSED ERNAVFQLEK AISSNKATSS
DLQMAVLSFE KDDDHNGHID FITAASNLRA KMYSIEPADR FKTKRIAGKI IPAIATSTAA
VSGLVALEMI KVAGDYPFEA YKNCFLNLAI PIIVFTETSE VKRTEIRNGI SFTIWDRWTI
HGKEDFTLLD FINAVKEKYG IEPTMVVQGV KMLYVPIMPG HAKRLKLTMH KLVKPSTEKK
YVDLTVSFAP DTDGDEDLPG PPVRYYFSHD TD
//
